Published Online
on June 6, 2005

A more recent version of this article appeared on July 1, 2005

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Submitted on January 31, 2005
Revised on February 23, 2005

Left Ventricular Hypertrophy Is More Prevalent in Blacks Than Whites in the General Population. The Dallas Heart Study

Mark H. Drazner^*; Daniel L. Dries; Ronald M. Peshock; Richard S. Cooper; Chris Klassen; Farhana Kazi; DuWayne Willett; and Ronald G. Victor

From the Heart Failure Research Unit (M.H.D., D.L.D.), Donald W. Reynolds Cardiovascular Clinical Research Center (M.H.D., D.L.D., R.G.V., R.M.P., C.K., F.K., D.W.), and Divisions of Cardiology (M.H.D., D.L.D., R.M.P., C.K., F.K., D.W.) and Hypertension (R.G.V.), Department of Internal Medicine University of Texas Southwestern Medical Center, Dallas; and the Department of Preventive Medicine and Epidemiology (R.S.C.), Loyola University, Maywood, Ill.

^* To whom correspondence should be addressed. E-mail: Mark.Drazner{at}utsouthwestern.edu.

Abstract--Although recent studies have suggested that blacks compared with whites have an increased prevalence of left ventricular hypertrophy, it remains uncertain whether this is true despite adjustment for body composition (fat mass and fat-free mass) and when assessed by cardiac MRI in the general population. The Dallas Heart Study is a population-based study of Dallas County in which 1335 black and 858 white participants 30 to 67 years of age underwent detailed assessment including dual-energy x-ray absorptiometry scan to measure body composition and cardiac MRI. Left ventricular hypertrophy, whether defined by indexation to body surface area (P<0.001), fat-free mass (P=0.002), or height^2.7 (P<0.001) was 2- to 3-fold more common in black versus white women. Similar results were seen when comparing black and white men (P<0.001 when left ventricular hypertrophy was indexed to body surface area or height^2.7 and P=0.05 when indexed to fat-free mass). Ethnic disparities in left ventricular mass persisted in multivariable models despite adjustment for fat mass, fat-free mass, systolic blood pressure, age, gender, and measures of socioeconomic status. We conclude that blacks compared with whites have increased left ventricular mass and a 2- to 3-fold higher prevalence of left ventricular hypertrophy in the general population, as assessed by cardiac MRI. The ethnic differences in left ventricular mass are independent of differences in body composition.

Key words: hypertrophy • ethnic groups • epidemiology • obesity

Related Article:

Left Ventricular Hypertrophy in Blacks and Whites: Different Genes or Different Exposure?

Giovanni de Simone
Hypertension 2005 46: 23-24. [Extract] [Full Text] [PDF]

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