Hypertension, Vol 1, 493-497, Copyright © 1979 by American Heart Association
JZ Miller, CE Grim, PM Conneally and MH Weinberger
Persons participating in a 5-day diagnostic protocol were routinely typed
for ABO, Rh, MNS, Kell, Kidd, Duffy, P, Haptoglobin, phosphoglucomutase-1
(PGM-1), and acid phosphatase (AcP). The study population was composed of
164 normotensive whites, 34 normotensive blacks, 161 whites and 43 blacks
with essential hypertension, and 52 whites with secondary forms of
hypertension (18 atherosclerotic renovascular hypertensives, 17 patients
with fibromuscular disease, and 17 patients with primary aldosteronism).
There were no significant differences in phenotype frequencies in ABO, Rh,
Kidd, Kell, Duffy, P, Haptoglobin, PGM-1 or AcP in any of the comparisons.
However, there was a significantly different distribution of MNS phenotypes
in comparisons of essential and atherosclerotic renovascular hypertensives
with normotensive controls. Essential hypertensives had a lower frequency
of the S gene and a higher frequency of s in whites (X2 = 12.21, p less
than 0.005). Atherosclerotic renovascular hypertensives differed from the
normotensive population in the frequencies of both MN (X 2 = 4.34, p less
than 0.05) and Ss (X2 = 4.21, p less than 0.05). The finding of
disease-blood group associations supports the hypothesis that there may be
significant physiological differences between individuals of different
blood types.
ARTICLES
Association of blood groups with essential and secondary hypertension. A possible association of the MNS system