This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Smith, T. L. Articles by Hutchins, P. M. Search for Related Content PubMed PubMed Citation Articles by Smith, T. L. Articles by Hutchins, P. M.

Hypertension, Vol 1, 508-517, Copyright © 1979 by American Heart Association

ARTICLES

Central hemodynamics in the developmental stage of spontaneous hypertension in the unanesthetized rat

TL Smith and PM Hutchins

The hemodynamic alterations associated with the developmental phase of high blood pressure were investigated in the spontaneously hypertensive rat (SHR). All hemodynamic measurements were made in unanesthetized, unrestrained SHR and Wistar-Kyoto (WKY) rats instrumented with chronic electromagnetic flow probes on the ascending aorta and arterial pressure catheters. Rats were studied at 30-41 days, 80 days, and 120 days of age. Hemodynamics of SHRs and WKYs in the 30-41 day group were monitored daily. Spontaneously hypertensive rats demonstrated a higher cardiac index than WKYs (p less than 0.05) from 32 through 41 days of age. Total peripheral resistance (TPR) was not elevated in SHRs at this time. Heart rate and stroke index were elevated in SHRs (p less than 0.05) from 34 through 41 days, however, stroke volume was not. At 80 and 120 days SHRs had higher mean arterial pressure (MAP) and TPR than WKYs (p less than 0.05), although cardiac index was not significantly different. This hemodynamic pattern of a hyperkinetic circulation prior to the development of hypertension supports the theory of total body autoregulation. A transient increase in cardiac index precedes an increase in TPR, which then normalizes cardiac index while elevating MAP.

This article has been cited by other articles:

				C. E. Rodriguez, D. A. Mahle, J. M. Gearhart, D. R. Mattie, J. C. Lipscomb, R. S. Cook, and H. A. Barton Predicting Age-Appropriate Pharmacokinetics of Six Volatile Organic Compounds in the Rat Utilizing Physiologically Based Pharmacokinetic Modeling Toxicol. Sci., July 1, 2007; 98(1): 43 - 56. [Abstract] [Full Text] [PDF]

				A. A. Perez-Rivera, G. D. Fink, and J. J. Galligan Increased Reactivity of Murine Mesenteric Veins to Adrenergic Agonists: Functional Evidence Supporting Increased {alpha}1-Adrenoceptor Reserve in Veins Compared with Arteries J. Pharmacol. Exp. Ther., January 1, 2004; 308(1): 350 - 357. [Abstract] [Full Text] [PDF]

				A. W. van Gorp, D. S. V. I. Schenau, A. P. G. Hoeks, H. A. J. S. Boudier, J. G. R. de Mey, and R. S. Reneman In spontaneously hypertensive rats alterations in aortic wall properties precede development of hypertension Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1241 - H1247. [Abstract] [Full Text] [PDF]

				J. Zicha and J. Kunes Ontogenetic Aspects of Hypertension Development: Analysis in the Rat Physiol Rev, October 1, 1999; 79(4): 1227 - 1282. [Abstract] [Full Text] [PDF]

				S. A Doggrell and L. Brown Rat models of hypertension, cardiac hypertrophy and failure Cardiovasc Res, July 1, 1998; 39(1): 89 - 105. [Full Text] [PDF]

				T. Fujino, N. Hasebe, M. Fujita, K. Takeuchi, J.-i. Kawabe, K. Tobise, S. Higashiyama, N. Taniguchi, and K. Kikuchi Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of spontaneously hypertensive rats Cardiovasc Res, May 1, 1998; 38(2): 365 - 374. [Abstract] [Full Text] [PDF]

				J. G. Dickhout and R. M. K. W. Lee Blood pressure and heart rate development in young spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H794 - H800. [Abstract] [Full Text] [PDF]

				R. Letienne, C. Barres, C. Cerutti, and C. Julien Short-term haemodynamic variability in the conscious areflexic rat J. Physiol., January 1, 1998; 506(1): 263 - 274. [Abstract] [Full Text] [PDF]

				P. Molino, C. Cerutti, C. Julien, G. Cuisinaud, M.-P. Gustin, and C. Paultre Beat-to-beat estimation of windkessel model parameters in conscious rats Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H171 - H177. [Abstract] [Full Text] [PDF]

				D. S. Martin, M. C. Rodrigo, and C. W. Appelt Venous Tone in the Developmental Stages of Spontaneous Hypertension Hypertension, January 1, 1998; 31(1): 139 - 144. [Abstract] [Full Text] [PDF]

				J. G. Dickhout and R. M.K.W. Lee Structural and Functional Analysis of Small Arteries From Young Spontaneously Hypertensive Rats Hypertension, March 1, 1997; 29(3): 781 - 789. [Abstract] [Full Text]

				A. W. van Gorp, D. S. van Ingen Schenau, A. P.G. Hoeks, H. A.J. S. Boudier, R. S. Reneman, and J. G.R. De Mey Aortic Wall Properties in Normotensive and Hypertensive Rats of Various Ages In Vivo Hypertension, August 1, 1995; 26(2): 363 - 368. [Abstract] [Full Text]