Hypertension, Vol 1, 529-536, Copyright © 1979 by American Heart Association
K Liu, AR Dyer, RS Cooper, R Stamler and J Stamler
Are overnight urine specimens adequate for characterizing the daily salt
intake of individuals, i.e., can the overnight specimen replace the 24-hour
specimen? Data from 142 male participants of an ongoing trial on the
primary prevention of hypertension were used to examine this question with
correlation analysis and quantile classification. Estimated correlation
between the true mean 24-hour and the true mean overnight sodium excretion
was 0.72. Furthermore, 67% of the individuals in the upper third of the
distribution of true mean overnight urine sodium were also in the upper
third of the distribution of true mean 24-hour sodium. Thus, these data are
promising in regard to the use of overnight urine specimens for
characterizing the salt intake of individuals. The number of overnight
urine collections required to estimate accurately the correlation between
an individual's true mean overnight urine sodium and a variable of interest
(e.g., blood pressure) was calculated. Given the observed intra- and inter-
individual variation, the data indicate that 14 measurements are needed to
limit the diminution of the correlation coefficient to 10%.
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Can overnight urine replace 24-hour urine collection to asses salt intake?
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