This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miller, A. W. Articles by Terris, J. M. Search for Related Content PubMed PubMed Citation Articles by Miller, A. W., 2d Articles by Terris, J. M.

Hypertension, Vol 1, 591-597, Copyright © 1979 by American Heart Association

ARTICLES

Hemodynamic responses to DOCA in young pigs

AW Miller 2d, DF Bohr, AM Schork and JM Terris

Hemodynamic variables were measured in 20 young pigs; thirteen received subcutaneous implantations of desoxycorticosterone acetate (DOCA) impregnated in Silastic strips, seven received implants of Silastic strips alone and served as controls. No salt was added to the standard diet of either group. Mean arterial pressure (MAP) rose in a regular pattern in the DOCA-treated pigs, reaching on the average a level significantly greater than that of the control group 48 hours after the implantation. Pressure continued to rise, reaching a plateau 38% above that of the preimplant value 2 weeks later. In some pigs the MAP elevation was caused by an increase in cardiac output (CO); in others it was caused by an increase in total peripheral resistance (TPR). An increase in central venous pressure occurred in many DOCA-treated pigs regardless of whether the increase in MAP was caused by an increase in CO or in TPR. The results indicate that it is arterial pressure per se that is the regulated variable in this model of mineralocorticoid hypertension. The regulating system, whether it resides in the kidney or in the central nervous system, elevates pressure by effecting increases in either CO or TPR.

This article has been cited by other articles:

				S. D. Blank, J. A. Lahorra, R. S. McDonald, A. G. Denenberg, J. S. Titus, D. F. Torchiana, W. M. Daggett, and G. A. Geffin Superior Recovery of Hypertrophied Rat Myocardium After Cardioplegic Arrest Ann. Thorac. Surg., February 1, 1998; 65(2): 390 - 396. [Abstract] [Full Text] [PDF]

				T. Kurtz and R. Morris Jr Dietary chloride as a determinant of "sodium-dependent" hypertension Science, December 9, 1983; 222(4628): 1139 - 1141. [Abstract] [PDF]

				R. L. TANNEN Effects of Potassium on Blood Pressure Control Ann Intern Med, May 1, 1983; 98(5_Part_2): 773 - 780. [Abstract] [PDF]