This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Safar, M. E. Articles by Chau, N. P. Search for Related Content PubMed PubMed Citation Articles by Safar, M. E. Articles by Chau, N. P.

Hypertension, Vol 1, 615-623, Copyright © 1979 by American Heart Association

ARTICLES

Rapid dextran infusion in essential hypertension

ME Safar, GM London, JA Levenson, AC Simon and NP Chau

Hemodynamic parameters were studied before and after rapid dextran infusion in 34 men including 17 patients with sustained essential hypertension and 17 normotensive controls. In both groups of patients, dextran infusion induced a significant increase (p less than 0.001) in central venous pressure (CVP), cardiac output (CO), and stroke volume. The percent change in stroke volume was significantly higher in hypertensives (p less than 0.001) than in controls. Three indices of volume expansion were calculated: 1) the ratio between the change in CO and the change in volume, which was significantly higher in hypertensives (p less than 0.025), 2) the ratio between the change in CO and the change in CVP, which was similar in both groups, and 3) the ratio between the change in volume and the change in CVP, which was significantly reduced in hypertensives (p less than 0.001). In the overall population, the latter ratio was negatively correlated with the change in CO (or in stroke volume) induced by expansion ( r = -0.75). The results provided evidence that: 1) the slope of the relationship between CO and blood volume was steeper in hypertensives than in normotensives, and 2) the steeper slope was due to a reduction in the effective compliance of the vascular bed, causing a greater elevation in CO per unit rise in volume.

This article has been cited by other articles:

				M. E. Safar, M. Temmar, A. Kakou, P. Lacolley, and S. N. Thornton Sodium Intake and Vascular Stiffness in Hypertension Hypertension, August 1, 2009; 54(2): 203 - 209. [Full Text] [PDF]

				M. E. Safar, G. M London, and G. E. Plante Arterial Stiffness and Kidney Function Hypertension, February 1, 2004; 43(2): 163 - 168. [Abstract] [Full Text] [PDF]

				M. Brinsuk, J. Tank, F. C. Luft, A. Busjahn, and J. Jordan Heritability of Venous Function in Humans Arterioscler Thromb Vasc Biol, January 1, 2004; 24(1): 207 - 211. [Abstract] [Full Text] [PDF]

				D. A. Edouard, B. M. Pannier, G. M. London, J. L. Cuche, and M. E. Safar Venous and arterial behavior during normal pregnancy Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1605 - H1612. [Abstract] [Full Text] [PDF]

				M. Wysocki, O. K. Andersson, B. Persson, and U. Bagge Vasoconstriction During Acute Hypervolemic Hemodilution in Hypertensive Patients is Not Prevented by Calcium Blockade Angiology, January 1, 1998; 49(1): 41 - 48. [Abstract] [PDF]

				F. STEPHAN, A. NOVARA, B. TOURNIER, J.-M. MAILLET, G. M. LONDON, M. E. SAFAR, and J.-Y. FAGON Determination of Total Effective Vascular Compliance in Patients with Sepsis Syndrome Am. J. Respir. Crit. Care Med., January 1, 1997; 157(1): 50 - 56. [Abstract] [Full Text]