Hypertension, Vol 10, 267-273, Copyright © 1987 by American Heart Association
AP Rocchini, V Katch, A Schork and RP Kelch
The role of insulin in the regulation of blood pressure was evaluated in 50
obese adolescents before and after a 20-week weight loss program. When
compared with 10 nonobese adolescents, the obese subjects had significantly
higher systolic, diastolic, and mean arterial pressures (p = 0.005), an
elevated 24-hour urinary sodium excretion (p = 0.002), an elevated fasting
insulin concentration (p = 0.001), and an abnormal insulin response to an
oral glucose tolerance test (sum of the insulins at 0, 1, and 2 hours
post-oral glucose load; p = 0.001). We also observed a significant
correlation between systolic and diastolic blood pressure (age and sex
normalized) and body weight (r = 0.57, p less than 0.01 and r = 0.7, p less
than 0.01), fasting insulin (r = 0.49, p less than 0.01 and r = 0.54, p
less than 0.01), and sum of insulins (r = 0.42, p less than 0.01 and r =
0.46, p less than 0.01). To study the effect of weight loss on the
relationship between blood pressure and insulin, the obese subjects were
randomly assigned to three groups: 15 to a diet and behavior change group,
18 to a diet, behavior change, and exercise group, and 17 to an obese
control group. Compared with the obese control group, the two weight loss
groups each experienced a significant decrease in insulin (p less than
0.01), sum of the insulins (p less than 0.01), and blood pressure (p less
than 0.01). The decrease in blood pressure during the weight loss program
significantly correlated with the change in both insulin and body
weight.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Insulin and blood pressure during weight loss in obese adolescents
This article has been cited by other articles:
 |
|
 |
|
  J. Steinberger, S. R. Daniels, R. H. Eckel, L. Hayman, R. H. Lustig, B. McCrindle, and M. L. Mietus-Snyder Progress and Challenges in Metabolic Syndrome in Children and Adolescents: A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism Circulation, February 3, 2009; 119(4): 628 - 647. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Szamosi, A. Czinner, T. Szamosi, A. Sallai, M. Hatunic, Z. Berla, E. Tomsits, Z. Almassy, and J. J. Nolan Effect of Diet and Physical Exercise Treatment on Insulin Resistance Syndrome of Schoolchildren J. Am. Coll. Nutr., February 1, 2008; 27(1): 177 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Bell, K. Watts, A. Siafarikas, A. Thompson, N. Ratnam, M. Bulsara, J. Finn, G. O'Driscoll, D. J. Green, T. W. Jones, et al. Exercise Alone Reduces Insulin Resistance in Obese Children Independently of Changes in Body Composition J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4230 - 4235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Collins, J. Warren, M. Neve, P. McCoy, and B. J. Stokes Measuring effectiveness of dietetic interventions in child obesity: a systematic review of randomized trials. Arch Pediatr Adolesc Med, September 1, 2006; 160(9): 906 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 American Heart Association, S. S. Gidding, B. A. Dennison, L. L. Birch, S. R. Daniels, M. W. Gilman, A. H. Lichtenstein, K. T. Rattay, J. Steinberger, N. Stettler, et al. Dietary Recommendations for Children and Adolescents: A Guide for Practitioners Pediatrics, February 1, 2006; 117(2): 544 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Endorsed by the American Academy of Pediatrics, S. S. Gidding, B. A. Dennison, L. L. Birch, S. R. Daniels, M. W. Gilman, A. H. Lichtenstein, K. T. Rattay, J. Steinberger, N. Stettler, et al. Dietary Recommendations for Children and Adolescents: A Guide for Practitioners: Consensus Statement From the American Heart Association Circulation, September 27, 2005; 112(13): 2061 - 2075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Sinaiko, J. Steinberger, A. Moran, R. J. Prineas, B. Vessby, S. Basu, R. Tracy, and D. R. Jacobs Jr Relation of Body Mass Index and Insulin Resistance to Cardiovascular Risk Factors, Inflammatory Factors, and Oxidative Stress During Adolescence Circulation, April 19, 2005; 111(15): 1985 - 1991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Kotsis, S. Stabouli, M. Bouldin, A. Low, S. Toumanidis, and N. Zakopoulos Impact of Obesity on 24-Hour Ambulatory Blood Pressure and Hypertension Hypertension, April 1, 2005; 45(4): 602 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Alberti, P. Zimmet, J. Shaw, Z. Bloomgarden, F. Kaufman, and M. Silink Type 2 Diabetes in the Young: The Evolving Epidemic: The International Diabetes Federation Consensus Workshop Diabetes Care, July 1, 2004; 27(7): 1798 - 1811. [Full Text] [PDF]
|
|
|
|
|
|
Z. T. Bloomgarden Type 2 Diabetes in the Young: The evolving epidemic Diabetes Care, April 1, 2004; 27(4): 998 - 1010. [Full Text] [PDF]
|
|
|
|
|
|
J. Steinberger and S. R. Daniels Obesity, Insulin Resistance, Diabetes, and Cardiovascular Risk in Children: An American Heart Association Scientific Statement From the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism) Circulation, March 18, 2003; 107(10): 1448 - 1453. [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Reaven Importance of Identifying the Overweight Patient Who Will Benefit the Most by Losing Weight Ann Intern Med, March 4, 2003; 138(5): 420 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sorof and S. Daniels Obesity Hypertension in Children: A Problem of Epidemic Proportions Hypertension, October 1, 2002; 40(4): 441 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Clay, M. J. Mordhorst, and L. Lehn Empirically Supported Treatments in Pediatric Psychology: Where Is the Diversity? J. Pediatr. Psychol., June 1, 2002; 27(4): 325 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Grandi, P. Zanzi, R. Broggi, A. Fachinetti, L. Guasti, L. Ceriani, and A. Venco Longitudinal Changes of Insulin Sensitivity in Essential Hypertension: Influence of Blood Pressure Control and Familial Predisposition to Hypertension J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3027 - 3031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Johnson, R. Figueroa-Colon, T. T.-K. Huang, J. H. Dwyer, and M. I. Goran Longitudinal Changes in Body Fat in African American and Caucasian Children: Influence of Fasting Insulin and Insulin Sensitivity J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3182 - 3187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Benthem, K. Keizer, C. H. Wiegman, S. F. de Boer, J. H. Strubbe, A. B. Steffens, F. Kuipers, and A. J. W. Scheurink Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1286 - E1293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Falkner, K. Sherif, S. Michel, and H. Kushner Dietary Nutrients and Blood Pressure in Urban Minority Adolescents at Risk for Hypertension Arch Pediatr Adolesc Med, September 1, 2000; 154(9): 918 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Sinaiko, R. P. Donahue, D. R. Jacobs Jr, and R. J. Prineas Relation of Weight and Rate of Increase in Weight During Childhood and Adolescence to Body Size, Blood Pressure, Fasting Insulin, and Lipids in Young Adults : The Minneapolis Children's Blood Pressure Study Circulation, March 23, 1999; 99(11): 1471 - 1476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Epstein, M. D. Myers, H. A. Raynor, and B. E. Saelens Treatment of Pediatric Obesity Pediatrics, March 1, 1998; 101(3): 554 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Sinaiko, O. Gomez-Marin, and R. J. Prineas Relation of Fasting Insulin to Blood Pressure and Lipids in Adolescents and Parents Hypertension, December 1, 1997; 30(6): 1554 - 1559. [Abstract] [Full Text]
|
|
|
|
|
|
T. Ikeda, T. Gomi, N. Hirawa, J. Sakurai, and N. Yoshikawa Improvement of Insulin Sensitivity Contributes to Blood Pressure Reduction After Weight Loss in Hypertensive Subjects With Obesity Hypertension, May 1, 1996; 27(5): 1180 - 1186. [Abstract] [Full Text]
|
|
|
|
|
|
M. Kawamura, T. Adachi, J. Nakajima, T. Fujiwara, and K. Hiramori Factors That Affect Calorie-Sensitive and Calorie-Insensitive Reduction in Blood Pressure During Short-term Calorie Restriction in Overweight Hypertensive Women Hypertension, March 1, 1996; 27(3): 408 - 413. [Abstract] [Full Text]
|
|
|
|
|
|
H. Kanai, K. Tokunaga, S. Fujioka, S. Yamashita, K. Kameda-Takemura, and Y. Matsuzawa Decrease in Intra-Abdominal Visceral Fat May Reduce Blood Pressure in Obese Hypertensive Women Hypertension, January 1, 1996; 27(1): 125 - 129. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. R. Black Treatment of Mild Hypertension: The More Things Change... JAMA, August 11, 1993; 270(6): 757 - 759. [Abstract] [PDF]
|
|
|
|
 |
|
 V. J. Stevens, S. A. Corrigan, E. Obarzanek, E. Bernauer, N. R. Cook, P. Hebert, M. Mattfeldt-Beman, A. Oberman, C. Sugars, A. T. Dalcin, et al. Weight Loss Intervention in Phase 1 of the Trials of Hypertension Prevention Arch Intern Med, April 12, 1993; 153(7): 849 - 858. [Abstract] [PDF]
|
|
|
|
|
|
N. M. Kaplan The Deadly Quartet: Upper-Body Obesity, Glucose Intolerance, Hypertriglyceridemia, and Hypertension Arch Intern Med, July 1, 1989; 149(7): 1514 - 1520. [Abstract] [PDF]
|
|