| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Hypertension, Vol 10, 328-338, Copyright © 1987 by American Heart Association
RM Lee, CR Triggle, DW Cheung and MD Coughlin
Neonatal sympathectomy of spontaneously hypertensive rats (SHR) and control
Wistar-Kyoto rats (WKY) was performed by a combined treatment with
antiserum to nerve growth factor and guanethidine during the first 4 weeks
after birth. The development of hypertension was completely prevented in
the treated SHR: at 28 to 30 weeks of age, systolic blood pressure of
treated SHR was 139 +/- 2 mm Hg as compared with 195 +/- 8 mm Hg in
untreated SHR. The extent of sympathectomy was verified by
histofluorescence. Fluorescence histochemistry for catecholamine-
containing nerves showed a complete absence of adrenergic nerves in the
mesenteric arteries of treated rats. A supersensitivity to norepinephrine
was exhibited by mesenteric arteries, anococcygeus muscle, and tail
arteries from the treated SHR and WKY. In the mesenteric vascular bed,
maximal response to norepinephrine was significantly reduced by
sympathectomy. Sympathectomy also abolished the responses (e.g., generation
of excitatory junctional potentials) of tail arteries to electrical
stimulation of perivascular nerves. Morphometric measurements of three
categories of mesenteric arteries showed that sympathectomy had no effect
on the hypertrophic change of smooth muscle cells in the conducting
vessels, but it prevented the hyperplastic changes of the muscle cells from
reactive, muscular arteries and small resistance vessels. These results
suggest that one of the primary roles of the overactive sympathetic nervous
system in the development of hypertension in SHR is manifested through its
trophic effect on the arteries of SHR. This trophic effect appears to cause
a hyperplastic change in the smooth muscle cells in the reactive and
resistance vessels, thereby contributing to the development of hypertension
in older SHR.
ARTICLES
Structural and functional consequence of neonatal sympathectomy on the blood vessels of spontaneously hypertensive rats
This article has been cited by other articles:
 |
|
 |
|
  M. A. Doczi, A. D. Morielli, and D. H. Damon Kv1.3 channels in postganglionic sympathetic neurons: expression, function, and modulation Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R733 - R740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Marko and D. H. Damon VEGF promotes vascular sympathetic innervation Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2646 - H2652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Berg Increased counteracting effect of eNOS and nNOS on an {alpha}1-adrenergic rise in total peripheral vascular resistance in spontaneous hypertensive rats Cardiovasc Res, September 1, 2005; 67(4): 736 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Baumbach, C. D. Sigmund, and F. M. Faraci Structure of Cerebral Arterioles in Mice Deficient in Expression of the Gene for Endothelial Nitric Oxide Synthase Circ. Res., October 15, 2004; 95(8): 822 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hague, P. J. Gonzalez-Cabrera, W. B. Jeffries, and P. W. Abel Relationship between alpha 1-Adrenergic Receptor-Induced Contraction and Extracellular Signal-Regulated Kinase Activation in the Bovine Inferior Alveolar Artery J. Pharmacol. Exp. Ther., October 1, 2002; 303(1): 403 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kishi, Y. Hirooka, K. Ito, K. Sakai, H. Shimokawa, and A. Takeshita Cardiovascular Effects of Overexpression of Endothelial Nitric Oxide Synthase in the Rostral Ventrolateral Medulla in Stroke-Prone Spontaneously Hypertensive Rats Hypertension, February 1, 2002; 39(2): 264 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Berk Vascular Smooth Muscle Growth: Autocrine Growth Mechanisms Physiol Rev, July 1, 2001; 81(3): 999 - 1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Reddi, V. R. Nimmagadda, and R. Arora Effect of Antihypertensive Therapy on Renal Artery Structure in Type 2 Diabetic Rats With Hypertension Hypertension, May 1, 2001; 37(5): 1273 - 1278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Damon VSM growth is stimulated in sympathetic neuron/VSM cocultures: role of TGF-beta 2 and endothelin Am J Physiol Heart Circ Physiol, February 1, 2000; 278(2): H404 - H411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Xin, N. Yang, and J. E. Faber Platelet-Derived Growth Factor-BB Inhibits Rat alpha 1D-Adrenergic Receptor Gene Expression in Vascular Smooth Muscle Cells by Inducing AP-2-Like Protein Binding to alpha 1D Proximal Promoter Region Mol. Pharmacol., December 1, 1999; 56(6): 1152 - 1161. [Abstract] [Full Text]
|
|
|
|
|
|
J. Zicha and J. Kunes Ontogenetic Aspects of Hypertension Development: Analysis in the Rat Physiol Rev, October 1, 1999; 79(4): 1227 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Chillon and G. L. Baumbach Effects of an Angiotensin-Converting Enzyme Inhibitor and a ß-Blocker on Cerebral Arterioles in Rats Hypertension, March 1, 1999; 33(3): 856 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Partovian, A. Benetos, J.-P. Pommies, W. Mischler, and M. E. Safar Effects of a chronic high-salt diet on large artery structure: role of endogenous bradykinin Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1423 - H1428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Charchar, M. Kapuscinski, and S. B. Harrap Persistent Reduction in Renal Nerve Growth Factor mRNA After Perindopril Treatment of Young Spontaneously Hypertensive Rats Hypertension, February 1, 1998; 31(2): 678 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. M. Stassen, R. G. H. T. Maas, P. M. H. Schiffers, G. M. J. Janssen, and J. G. R. De Mey A Positive and Reversible Relationship Between Adrenergic Nerves and Alpha-1A Adrenoceptors in Rat Arteries J. Pharmacol. Exp. Ther., January 1, 1998; 284(1): 399 - 405. [Abstract] [Full Text]
|
|
|
|
|
|
J.-M. Chillon, S. Ghoneim, and G. L. Baumbach Effects of Chronic Nitric Oxide Synthase Inhibition on Cerebral Arterioles in Rats Hypertension, November 1, 1997; 30(5): 1097 - 1104. [Abstract] [Full Text]
|
|
|
|
|
|
M. Sander, J. Hansen, and R. G. Victor The Sympathetic Nervous System Is Involved in the Maintenance but Not Initiation of the Hypertension Induced by N{omega}-Nitro-L-Arginine Methyl Ester Hypertension, July 1, 1997; 30(1): 64 - 70. [Abstract] [Full Text]
|
|
|
|
|
|
S. Fujii, K. Kameyama, M. Hosono, Y. Hayashi, and K. Kitamura Effect of Cilnidipine, a Novel Dihydropyridine Ca++-channel antagonist, on N-type Ca++ Channel in Rat Dorsal Root Ganglion Neurons J. Pharmacol. Exp. Ther., March 1, 1997; 280(3): 1184 - 1191. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. deBlois, S.M. Schwartz, E.M. van Kleef, J.E. Su, K.A. Griffin, A.K. Bidani, M.J.A.P. Daemen, and D.M. Lombardi Chronic {alpha}1-Adrenoreceptor Stimulation Increases DNA Synthesis in Rat Arterial Wall: Modulation of Responsiveness After Vascular Injury Arterioscler Thromb Vasc Biol, September 1, 1996; 16(9): 1122 - 1129. [Abstract] [Full Text]
|
|
|
|
|
|
R. McCarty and J. H. Lee Preweanling Administration of Terazosin Decreases Blood Pressure of Hypertensive Rats in Adulthood Hypertension, May 1, 1996; 27(5): 1115 - 1120. [Abstract] [Full Text]
|
|
|
|
|
|
J.-M. Chillon, D. D. Heistad, and G. L. Baumbach Effects of Endothelin Receptor Inhibition on Cerebral Arterioles in Hypertensive Rats Hypertension, March 1, 1996; 27(3): 794 - 798. [Abstract] [Full Text]
|
|
|
|
|
|
G. L. Baumbach Effects of Increased Pulse Pressure on Cerebral Arterioles Hypertension, February 1, 1996; 27(2): 159 - 167. [Abstract] [Full Text]
|
|
|
|
|
|
M. Sander, P. G. Hansen, and R. G. Victor Sympathetically Mediated Hypertension Caused by Chronic Inhibition of Nitric Oxide Hypertension, October 1, 1995; 26(4): 691 - 695. [Abstract] [Full Text]
|
|
|
|
|
|
M. J.A.P. Daemen and J. G.R. De Mey Regional Heterogeneity of Arterial Structural Changes Hypertension, April 1, 1995; 25(4): 464 - 473. [Abstract] [Full Text]
|
|