Hypertension, Vol 10, 512-516, Copyright © 1987 by American Heart Association
IS Hwang, H Ho, BB Hoffman and GM Reaven
To determine if hypertension could be produced in normal rats by feeding
them a fructose-enriched diet, Sprague-Dawley rats were fed either normal
chow or a diet containing 66% fructose as a percentage of total calories
for approximately 2 weeks. At the end of this period systolic blood
pressure had increased from 124 +/- 2 to 145 +/- 2 (SEM) mm Hg in the
fructose-fed rats, whereas no change occurred in the control group. In
addition, hyperinsulinemia and hypertriglyceridemia were associated with
hypertension in fructose-fed rats. The addition of clonidine to the
drinking water inhibited fructose-induced hypertension, but not the
increase in plasma insulin or triglyceride concentration seen in
fructose-fed rats. Thus, the metabolic changes associated with
fructose-induced hypertension are unlikely to be secondary to an increase
in sympathetic activity. Whether or not this is also true of the
hypertension remains to be clarified.
ARTICLES
Fructose-induced insulin resistance and hypertension in rats
Department of Medicine, Stanford University School of Medicine, Palo Alto, California.
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