Hypertension, Vol 10, 533-537, Copyright © 1987 by American Heart Association
AU Ferrari, A Daffonchio, F Albergati and G Mancia
The interplay of heart rate variability, baroreceptor control of heart
rate, and blood pressure (BP) variability was examined in chronically
instrumented, unanesthetized, freely moving rats in which the efferent
neural influences on heart rate were pharmacologically altered. In each
rat, BP was recorded continuously for 90 minutes in the control condition
and in one or more of the following conditions: 1) beta- adrenergic
receptor blockade by propranolol, 1 mg/kg; 2) cholinergic blockade by
atropine, 0.75 mg/kg, and 3) combined blockade by propranolol plus
atropine. Each BP recording was analyzed beat-to-beat by a computer that
calculated heart rate and BP variabilities, both expressed as variation
coefficients. In addition, under each condition the sensitivity of the
arterial baroreceptor control of heart rate was assessed by measuring the
reflex changes in pulse interval in response to BP changes induced by bolus
i.v. injections of phenylephrine and nitroprusside. As compared with the
control condition, 1) propranolol (n = 10) reduced heart rate variability
by 23 +/- 4% (p less than 0.01), only slightly impaired baroreceptor reflex
sensitivity, and did not significantly modify BP variability (+11 +/- 7%);
2) atropine (n = 11) reduced heart rate variability by 30 +/- 7% (p less
than 0.01), drastically impaired baroreceptor reflex sensitivity, and
increased BP variability (+40 +/- 8%, p less than 0.01); 3) combined
blockade (n = 10) caused variability and baroreceptor reflex changes
similar to those induced by atropine alone. Thus, heart rate variability
depends on both vagal and sympathetic influences. However, only the former
component affects BP variability, that is, it plays an antioscillatory
role.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Inverse relationship between heart rate and blood pressure variabilities in rats
Centro di Fisiologia Clinica e Ipertensione, Ospedale Maggiore, Milano, Italy.
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