Hypertension, Vol 11, 440-444, Copyright © 1988 by American Heart Association
B Tesfamariam and W Halpern
The endothelium-dependent and presumed endothelium-independent vasodilators
acetylcholine and sodium nitroprusside, respectively, were used to
characterize relaxation responses of mesenteric resistance arteries from
stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto rats
(WKY). Vessels were preconstricted using concentrations of norepinephrine
or 5-hydroxytryptamine, which reduced their diameters by 50 to 60%.
Relaxation responses to acetylcholine (10(-8) - 10(-7) M) were
significantly smaller (p less than 0.05) in vessel segments from SHRSP, but
the maximal relaxations at higher concentrations were the same in both
strains. However, SHRSP vessels relaxed to a greater extent than did those
of the WKY at all concentrations of sodium nitroprusside. Endothelium
removal significantly enhanced sodium nitroprusside-induced dilations in
both rat strains, and the dilations were significantly greater in segments
from SHRSP in the concentration range of 3 X 10(-8) to 10(-6) M. The
decreased relaxation to acetylcholine in resistance arteries from adult
hypertensive rats compared with those from the normotensive strain suggests
that functional alterations in the endothelium may play a role in
hypertensive disease.
ARTICLES
Endothelium-dependent and endothelium-independent vasodilation in resistance arteries from hypertensive rats
Department of Physiology and Biophysics, University of Vermont, College of Medicine, Burlington.
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