This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Laragh, J. H. Articles by Alderman, M. H. Search for Related Content PubMed PubMed Citation Articles by Laragh, J. H. Articles by Alderman, M. H.

Hypertension, Vol 12, 223-226, Copyright © 1988 by American Heart Association

ARTICLES

Diagnosis ex juvantibus. Individual response patterns to drugs reveal hypertension mechanisms and simplify treatment

JH Laragh, B Lamport, J Sealey and MH Alderman
Cardiovascular Center, New York Hospital-Cornell Medical Center, NY 10021.

Heterogeneity of response to antihypertensive therapy is a well- recognized clinical phenomenon. An agent that is antihypertensive in one patient may increase blood pressure in another or have no effect in a third. We believe that this variety of individual response to drug treatment can provide a new framework for the study of hypertensive subjects. Different patterns of response elicited by sequential trials of individual drugs with different mechanisms of action (diuretics, calcium channel blockers, alpha-blockers, beta-blockers, and converting enzyme inhibitors) should provide another means to classify hypertensive patients into biologically relevant groups. The documentation and analysis of this therapeutic heterogeneity in relation to renin profiling and to other physiological and demographic parameters may add a new dimension to the investigation of the pathophysiology of hypertension; it may serve as a basis for more appropriate stratification of participants in clinical trials and may ultimately contribute to a more rational approach to patient management.

This article has been cited by other articles:

				D. Parra, R. Rosenstein, M. H. Strauss, J. Weinstein, G. E. Newton, B. R. Davis, P. K. Whelton, the ALLHAT Collaborative Research Group, K. A. Jamerson, and M. A. Weber Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension N. Engl. J. Med., March 12, 2009; 360(11): 1147 - 1150. [Full Text] [PDF]

				S. T. Turner, K. R. Bailey, B. L. Fridley, A. B. Chapman, G. L. Schwartz, H. S. Chai, H. Sicotte, J.-P. Kocher, A. S. Rodin, and E. Boerwinkle Genomic Association Analysis Suggests Chromosome 12 Locus Influencing Antihypertensive Response to Thiazide Diuretic Hypertension, August 1, 2008; 52(2): 359 - 365. [Abstract] [Full Text] [PDF]

				S. T. Turner, G. L. Schwartz, A. B. Chapman, and E. Boerwinkle WNK1 Kinase Polymorphism and Blood Pressure Response to a Thiazide Diuretic Hypertension, October 1, 2005; 46(4): 758 - 765. [Abstract] [Full Text] [PDF]

				M. H. Alderman The Return on INVEST JAMA, December 3, 2003; 290(21): 2859 - 2861. [Full Text] [PDF]

				M. T. Sciarrone, P. Stella, C. Barlassina, P. Manunta, C. Lanzani, G. Bianchi, and D. Cusi ACE and {alpha}-Adducin Polymorphism as Markers of Individual Response to Diuretic Therapy Hypertension, March 1, 2003; 41(3): 398 - 403. [Abstract] [Full Text] [PDF]

				M. J Brown HYPERTENSION: Matching the right drug to the right patient in essential hypertension Heart, July 1, 2001; 86(1): 113 - 120. [Full Text] [PDF]

				S. T. Turner, G. L. Schwartz, A. B. Chapman, and E. Boerwinkle C825T Polymorphism of the G Protein {beta}3-Subunit and Antihypertensive Response to a Thiazide Diuretic Hypertension, February 1, 2001; 37(2): 739 - 743. [Abstract] [Full Text] [PDF]

				G. Emilien, M. Ponchon, C. Caldas, O. Isacson, and J.-M. Maloteaux Impact of genomics on drug discovery and clinical medicine QJM, July 1, 2000; 93(7): 391 - 423. [Abstract] [Full Text] [PDF]

				G. Chatellier, M. Day, G. Bobrie, and J. Menard Feasibility Study of N-of-1 Trials With Blood Pressure Self-Monitoring in Hypertension Hypertension, February 1, 1995; 25(2): 294 - 301. [Abstract] [Full Text]

				R. R. Townsend and O. B. Holland Combination of Converting Enzyme Inhibitor With Diuretic for the Treatment of Hypertension Arch Intern Med, June 1, 1990; 150(6): 1175 - 1183. [Abstract] [PDF]