This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schedl, H. P. Articles by Horst, R. L. Search for Related Content PubMed PubMed Citation Articles by Schedl, H. P. Articles by Horst, R. L.

Hypertension, Vol 12, 310-316, Copyright © 1988 by American Heart Association

ARTICLES

Calcium transport and vitamin D in three breeds of spontaneously hypertensive rats

HP Schedl, HD Wilson and RL Horst
Medical Service, Veterans Administration Medical Center, Iowa City, Iowa.

Conflicting results have been published by different laboratories comparing the rate of intestinal calcium transport and concentration of circulating 1,25-dihydroxyvitamin D (1,25-[OH]2D) in the spontaneously hypertensive rat (SHR) and control Wistar-Kyoto rat (WKY): They have been reported to be greater, the same, or lower in the SHR than in the WKY. We tested the possibility that the conflicting results might be breeder-related by measuring 1) the rate of intestinal mucosal calcium transport, 2) the concentration of circulating 25-hydroxyvitamin D (25- OH-D) and 1,25-(OH)2D, and 3) the concentration of intestinal mucosal receptor for 1,25-(OH)2D in the two strains of animals from three different breeders. Sodium and water transport were also measured because of their relevance to hypertension. Blood pressure was always higher and calcium, as well as mean sodium and water transport, was always lower in the SHR than in the WKY. The concentration of 1,25- (OH)2D was the same, higher, or lower in the SHR than in the WKY and was age- and breeder-dependent. Mean mucosal 1,25-(OH)2D receptor concentration was higher in the SHR and was variable, depending on breeder. We conclude that 1) the rate of calcium transport is lower in the SHR than in the WKY and independent of breeder and concentration of 1,25-(OH)2D in serum, 2) the variability in 1,25-(OH)2D concentration among investigators may be breeder-dependent, and 3) the higher receptor concentration in the intestinal mucosa of the SHR could be a compensatory response to the decreased rate of calcium transport. These differences in calcium and sodium transport may be an expression in the enterocyte of factors etiological for hypertension.

This article has been cited by other articles:

				S. G. Rostand Ultraviolet Light May Contribute to Geographic and Racial Blood Pressure Differences Hypertension, August 1, 1997; 30(2): 150 - 156. [Abstract] [Full Text]