This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Finkelstein, S. M. Articles by Cohn, J. N. Search for Related Content PubMed PubMed Citation Articles by Finkelstein, S. M. Articles by Cohn, J. N.

Hypertension, Vol 12, 380-387, Copyright © 1988 by American Heart Association

ARTICLES

Arterial vascular compliance response to vasodilators by Fourier and pulse contour analysis

SM Finkelstein, VR Collins and JN Cohn
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.

Vasodilator drugs are widely used in the management of cardiovascular disease. They decrease systemic vascular resistance, but they also may influence vascular arterial compliance. This study evaluated the effects of three vasodilators--nitroprusside, nitroglycerin, and hydralazine--on vascular compliance using impedance parameters determined by pulse contour and Fourier analyses. The open chest study was performed on anesthetized dogs. Mean arterial pressure decreased by a minimum of 20% after vasodilator intervention. The decrease in systemic vascular resistance was significant (p less than 0.01) only after hydralazine treatment. Proximal compliance increased after administration of all drugs, but the increase was not statistically significant. Distal compliance determined by pulse contour analysis increased by 60 to 120% after all three drug treatments (p less than 0.05 for nitroprusside, p less than 0.02 for nitroglycerin and hydralazine). Characteristic impedance from Fourier analysis responded variably, and changes were not statistically significant. The sensitivity of changes in distal compliance as a marker for the vascular effect of these drugs suggests that it might be used as a more reliable guide than blood pressure or vascular resistance in monitoring clinical response to such intervention. The more traditional measure of characteristic impedance provides a vascular measurement that is less sensitive than distal compliance to the effects of these vasodilator drugs.

This article has been cited by other articles:

				S. S. DeLoach and R. R. Townsend Vascular Stiffness: Its Measurement and Significance for Epidemiologic and Outcome Studies Clin. J. Am. Soc. Nephrol., January 1, 2008; 3(1): 184 - 192. [Abstract] [Full Text] [PDF]

				S. Laurent, J. Cockcroft, L. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I. Wilkinson, H. Struijker-Boudier, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications Eur. Heart J., November 1, 2006; 27(21): 2588 - 2605. [Abstract] [Full Text] [PDF]

				J. L. Izzo Jr, T. S. Manning, and B. E. Shykoff Office Blood Pressures, Arterial Compliance Characteristics, and Estimated Cardiac Load Hypertension, December 1, 2001; 38(6): 1467 - 1470. [Abstract] [Full Text] [PDF]

				D. Duprez, M. De Buyzere, L De Bruyne, D. Clement, and J. Cohn Small and large artery elasticity indices in peripheral arterial occlusive disease (PAOD) Vascular Medicine, November 1, 2001; 6(4): 211 - 214. [Abstract] [PDF]

				D. Baldassarre, M. Amato, C. Palombo, C. Morizzo, L. Pustina, and C. R. Sirtori Time course of forearm arterial compliance changes during reactive hyperemia Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1093 - H1103. [Abstract] [Full Text] [PDF]

				E.-R. Rietzschel, E. Boeykens, M. L. De Buyzere, D. A. Duprez, and D. L. Clement A Comparison Between Systolic and Diastolic Pulse Contour Analysis in the Evaluation of Arterial Stiffness Hypertension, June 1, 2001; 37 (6): e15 - e22. [Abstract] [Full Text] [PDF]

				P. Molino, C. Cerutti, C. Julien, G. Cuisinaud, M.-P. Gustin, and C. Paultre Beat-to-beat estimation of windkessel model parameters in conscious rats Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H171 - H177. [Abstract] [Full Text] [PDF]

				P. J. Nestel, S. E. Pomeroy, T. Sasahara, T. Yamashita, Y. L. Liang, A. M. Dart, G. L. Jennings, M. Abbey, and J. D. Cameron Arterial Compliance in Obese Subjects Is Improved With Dietary Plant n-3 Fatty Acid From Flaxseed Oil Despite Increased LDL Oxidizability Arterioscler Thromb Vasc Biol, June 1, 1997; 17(6): 1163 - 1170. [Abstract] [Full Text]