Hypertension, Vol 13, 243-249, Copyright © 1989 by American Heart Association
K Nakamura and AW Cowley Jr
The role of sodium retention and consequent changes in cerebrospinal fluid
sodium concentration in the genesis of hypertension in Dahl rats was
evaluated. Dahl salt-sensitive (DS, n = 7), Dahl salt-resistant (DR, n =
7), and Sprague-Dawley (n = 6) rats were housed in metabolic cages and
instrumented with a stainless steel cannula in the cisterna magna and a
femoral arterial catheter. A blood sample was drawn daily (200
microliters), and cerebrospinal fluid was collected by continuous 24-hour
withdrawal (200 microliters/day). Daily sodium, potassium, and water
balances were also determined. Rats were studied sequentially on 0.4%, 4%,
and 8% sodium diets (7 days per sodium level). Mean arterial pressure
increased with 4% NaCl from 107 to 120 mm Hg (p less than 0.05) over 24
hours in DS rats and remained at about that level until the NaCl was
increased to 8%, which resulted in a gradual rise of mean arterial pressure
over the next 7 days to 135 mm Hg. Cerebrospinal fluid sodium was unchanged
in DR and Sprague-Dawley rats fed 4% or 8% sodium, but in DS rats rose from
152.3 to 155.2 +/- 0.6 meq/l on the third day at 4% sodium and remained
elevated over the next 2 weeks of study. Blood sodium was unchanged
throughout the study in all groups. On the first day only of the 4% and 8%
sodium diets, both DS and DR rats exhibited a similar net retention of
sodium, which was greater than the Sprague-Dawley rats (p less than
0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Sequential changes of cerebrospinal fluid sodium during the development of hypertension in Dahl rats
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
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