This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Malo, D. Articles by Hamet, P. Search for Related Content PubMed PubMed Citation Articles by Malo, D. Articles by Hamet, P.

Hypertension, Vol 14, 121-128, Copyright © 1989 by American Heart Association

ARTICLES

Thermosensitivity, a possible new locus involved in genetic hypertension

D Malo, G Schlager, J Tremblay and P Hamet
Clinical Research Institute of Montreal, Quebec, Canada.

Spontaneously hypertensive mice have been characterized as more sensitive to environmental heat than normotensive mice. A breeding program was therefore initiated to examine the possible genetic link between thermosensitivity and hypertension. Crossbreeding of spontaneously hypertensive mice with randomly bred normotensive mice produced F1 hybrids, which were then intercrossed to create a F2 population. Thermosensitivity was measured with a noninvasive method. The rate of body temperature increase was significantly (p less than 0.001) higher in the hypertensive mice (1.74 +/- 0.04 degrees C/min) compared with normal controls (1.13 +/- 0.03 degrees C/min). The frequency distribution of the rate of body temperature increase among the progenies was consistent with the hypothesis that a single gene locus determines the observed difference in thermosensitivity between normal and hypertensive mice. The allele that determines the rate of body temperature increase in normal mice was dominant in relation to the allele contributed by hypertensive mice. In the F2 population, a bimodal distribution determined two phenotypes: less than 1.40 degrees C/min and greater than 1.40 degrees C/min. A significant difference (p less than 0.01) in blood pressure of 11 mm Hg was observed between these two phenotypes. In addition, a positive correlation (p less than 0.01) was noted between the rate of body temperature increase and blood pressure in the F2 progeny. We conclude that there is possibly a single locus controlling thermosensitivity, which exhibits additive-dominance inheritance. Alleles of this particular trait segregate in part with an increment in blood pressure. The results support the possibility that the increased thermosensitivity seen in hypertensive mice is associated with one of the genes that contributes to their high blood pressure.

This article has been cited by other articles:

				S. Thifault, S. Ondrej, Y. Sun, A. Fortin, E. Skamene, R. Lalonde, J. Tremblay, and P. Hamet Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genes Hum. Mol. Genet., February 1, 2008; 17(3): 331 - 344. [Abstract] [Full Text] [PDF]

				S. H.H. Chan, L.-L. Wang, K.-F. Chang, C.-C. Ou, and J. Y.H. Chan Altered Temporal Profile of Heat Shock Factor 1 Phosphorylation and Heat Shock Protein 70 Expression Induced by Heat Shock in Nucleus Tractus Solitarii of Spontaneously Hypertensive Rats Circulation, January 21, 2003; 107(2): 339 - 345. [Abstract] [Full Text] [PDF]

				L. H. E. H. Snoeckx, R. N. Cornelussen, F. A. Van Nieuwenhoven, R. S. Reneman, and G. J. Van der Vusse Heat Shock Proteins and Cardiovascular Pathophysiology Physiol Rev, October 1, 2001; 81(4): 1461 - 1497. [Abstract] [Full Text] [PDF]

				A. G. Pockley, R. Wu, C. Lemne, R. Kiessling, Ulf de Faire, and J. Frostegard Circulating Heat Shock Protein 60 Is Associated With Early Cardiovascular Disease Hypertension, August 1, 2000; 36(2): 303 - 307. [Abstract] [Full Text] [PDF]

				P. Dumas, Z. Pausova, V. Kren, D. Krenova, M. Pravenec, M. Dumont, D. Ely, M. Turner, Y. Sun, J. Tremblay, et al. Contribution of Autosomal Loci and the Y Chromosome to the Stress Response in Rats Hypertension, February 1, 2000; 35(2): 568 - 573. [Abstract] [Full Text] [PDF]

				J. Frostegard, C. Lemne, B. Andersson, R. van der Zee, R. Kiessling, and U. de Faire Association of Serum Antibodies to Heat-Shock Protein 65 With Borderline Hypertension Hypertension, January 1, 1997; 29(1): 40 - 44. [Abstract] [Full Text]