Hypertension, Vol 14, 511-517, Copyright © 1989 by American Heart Association
J Fagius and S Karhuvaara
Microneurographic recordings of muscle nerve sympathetic activity, which is
governed by baroreceptors and involved in blood pressure regulation, were
made in the peroneal nerve in 16 healthy volunteers during physiological
bladder distension. When the urge to urinate was pronounced, sympathetic
outflow increased from a baseline level of 16.3 +/- 1.7 to 23.2 +/- 1.9
bursts/min (mean +/- SEM, p less than 0.01). There was a concomitant
significant rise in both systolic and diastolic blood pressure, from 125
+/- 2/74 +/- 2 to 140 +/- 4/84 +/- 3 mm Hg. After micturition, sympathetic
activity and blood pressure returned toward initial values. It is concluded
that 1) increased sympathetic outflow contributed to the rise in blood
pressure, 2) there is a vesicovascular response mediated by sympathetic
vasoconstrictor neurons in humans corresponding to mechanisms observed in
animals, and 3) the described functional relation between bladder
distension and sympathetic vasoconstrictor activity probably plays a role
in clinical conditions such as autonomic dysreflexia in humans with
cervical spinal cord lesions and nocturnal micturition syncope.
ARTICLES
Sympathetic activity and blood pressure increases with bladder distension in humans
Department of Neurology, University Hospital, Uppsala, Sweden.
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