Hypertension, Vol 15, 170-176, Copyright © 1990 by American Heart Association
HK Jin, RH Yang, YF Chen and S Oparil
Our previous studies demonstrated that acute infusion of atrial natriuretic
factor (ANF) produces an enhanced depressor response in NaCl-sensitive
spontaneously hypertensive rats (SHR-S) fed a high (8%) NaCl diet compared
with control SHR-S fed a normal (1%) NaCl diet and that dietary NaCl
loading increases circulating ANF levels in Wistar- Kyoto (WKY) rats but
not in SHR-S. The current study tested the hypotheses that 1) long-term
infusion of ANF at a dose that elevates plasma ANF to levels comparable
with those seen in high NaCl-fed WKY rats prevents the NaCl-induced
exacerbation of hypertension in SHR-S and 2) ANF lowers blood pressure in
this model by a sympatholytic effect. Male SHR-S received infusions of ANF
(0.1 microgram/hr) or vehicle intravenously via osmotic minipump for 3
weeks beginning immediately before initiation of 1% or 8% NaCl diets at age
7 weeks. Chronic ANF infusion prevented the increase in arterial pressure
in response to a high NaCl diet in SHR-S but had no effect in 1% NaCl-fed
SHR-S. Thus, the NaCl-sensitive component of hypertension in SHR-S was more
sensitive to ANF than the non-NaCl-sensitive component. Plasma
norepinephrine was significantly increased in ANF-treated, 8% NaCl-fed
SHR-S compared with vehicle controls, suggesting that ANF did not prevent
NaCl-sensitive hypertension by a sympatholytic effect.(ABSTRACT TRUNCATED
AT 250 WORDS)
ARTICLES
Atrial natriuretic factor prevents NaCl-sensitive hypertension in spontaneously hypertensive rats
Department of Medicine, University of Alabama, Birmingham 35294.
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