Hypertension, Vol 15, 318-326, Copyright © 1990 by American Heart Association
M Volpe, MJ Camargo, FB Mueller, WG Campbell Jr, JE Sealey, MS Pecker, RE Sosa and JH Laragh
We studied the effects of regular diet (0.35% NaCl/1.1% potassium), high
sodium diet (4% NaCl/0.75% potassium), or high sodium and high potassium
diet (4% NaCl/2.11% potassium) on blood pressure, plasma renin activity,
renal and cerebrovascular lesions, and incidence of stroke and mortality in
male stroke-prone spontaneously hypertensive rats (SHRSP). In the first 4
weeks, the rise in blood pressure was higher in high NaCl than in high
NaCl/high potassium or regular diet groups. However, by 8 and 12 weeks, the
blood pressure in all three groups was similar. After 4 weeks of diet,
plasma renin activity was similar in the three groups (3.4 +/- 0.8, 4.1 +/-
0.9, and 5.2 +/- 1.6 ng/ml/hr, in high NaCl, high NaCl/high potassium, and
regular diet groups, respectively) and were not related to sodium
excretion. After 8 weeks, plasma renin activity was significantly increased
only in the high NaCl group (13.7 +/- 3.7 ng/ml/hr), and by 12 weeks plasma
renin activity was significantly higher in the high NaCl group (25.3 +/-
3.6 ng/ml/hr) than in the high NaCl/high potassium (11.1 +/- 2.9 ng/ml/hr)
or in the regular diet (7.8 +/- 4.6 ng/ml/hr) groups. Moderate to severe
renal vascular lesions were first detected in the high NaCl group by 8
weeks of diet. At 12 weeks, renal vascular damage index (RVDI), estimated
histologically, was significantly higher in the high NaCl group (RVDI = 79
+/- 14) than in the high NaCl/high potassium (RVDI = 40 +/- 11) and regular
diet (RVDI = 7.8 +/- 4.6) groups.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Relation of plasma renin to end organ damage and to protection of K+ feeding in stroke-prone hypertensive rats
Department of Medicine, Cornell University Medical College, New York, New York.
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