Hypertension, Vol 15, 429-435, Copyright © 1990 by American Heart Association
R Rettig, CG Folberth, H Stauss, D Kopf, R Waldherr, G Baldauf and T Unger
Renal transplantations were performed, using microsurgical techniques, with
adult male two-kidney, one clip hypertensive rats (n = 9) and sham-
operated normotensive Wistar-Kyoto rats (n = 8) as kidney donors and with
F1 hybrids, bred from Wistar-Kyoto and stroke-prone spontaneously
hypertensive rat parents, as recipients. Systolic blood pressure before
surgery was 200 +/- 2.7 mm Hg in hypertensive and 115 +/- 1.7 mm Hg in
normotensive donors and 144 +/- 7.1 and 138 +/- 3.5 mm Hg in the two groups
of recipients. Renal hypertension in donors was maintained for 14 weeks
before surgery was performed and the nonischemic kidneys were transplanted.
Bilaterally nephrectomized recipients of renal grafts from hypertensive
donors developed sustained hypertension (185 +/- 3.9 mm Hg). In contrast,
in recipients of renal grafts from normotensive donors, blood pressure
decreased significantly to the level of the donors (111 +/- 3.7 mm Hg).
Posttransplantation hypertension in recipients of renal grafts from
hypertensive donors was associated with intrarenal vascular hypertrophy,
smaller kidneys, a decreased glomerular filtration rate, an increased
plasma urea concentration, and polydipsia as compared with normotensive
transplanted controls. Renal pyelograms revealed no gross anatomic
alterations of transplanted kidneys. Our data indicate that secondary
damage to the renal grafts caused by high perfusion pressure before
transplantation can induce hypertension in recipients of these kidneys.
Furthermore, our data suggest that renal mechanisms may be necessary to
maintain borderline hypertension in F1 hybrids.
ARTICLES
Hypertension in rats induced by renal grafts from renovascular hypertensive donors
Department of Pharmacology, German Institute for Hypertension Research, University of Heidelberg, FRG.
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