Hypertension, Vol 15, 486-492, Copyright © 1990 by American Heart Association
SM Gardiner, AM Compton, T Bennett, RM Palmer and S Moncada
The regional hemodynamic consequences of inhibiting vascular endothelial
nitric oxide generation with NG-monomethyl-L-arginine (L- NMMA) were
studied in conscious Long-Evans rats. Experiments were carried out in
groups of chronically instrumented rats with intravascular catheters and
pulsed Doppler probes to monitor regional blood flow. L-NMMA (0.3-300
mg/kg) caused a dose-dependent, long- lasting (5-90 minutes), and
enantiomerically specific increase in mean blood pressure and also caused
bradycardia. The increase in blood pressure was accompanied by a
dose-dependent and long-lasting vasoconstriction in the internal carotid,
mesenteric, renal, and hindquarters vascular beds that could be attenuated,
in a concentration- dependent manner, by L-arginine but not by D-arginine.
In contrast, L- arginine did not affect the pressor or vasoconstrictor
effects of vasopressin. These results indicate that nitric oxide production
by vascular endothelial cells contributes to the maintenance of blood
pressure and to the control of the resting tone of different vascular beds
in the conscious rat.
ARTICLES
Control of regional blood flow by endothelium-derived nitric oxide
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, UK.
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