Hypertension, Vol 15, 493-496, Copyright © 1990 by American Heart Association
M Shichiri, Y Hirata, K Ando, T Emori, K Ohta, S Kimoto, M Ogura, A Inoue and F Marumo
Endothelin-1 is a novel endothelium-derived vasoconstrictive peptide. Using
a highly specific and sensitive radioimmunoassay for endothelin- 1, plasma
levels of immunoreactive endothelin-1 were measured in 32 research subjects
with normal renal function (21 normal subjects and 11 patients with
essential hypertension), 24 patients with nondialyzed chronic renal
failure, and 51 patients undergoing maintenance hemodialysis. Although
there was no significant difference in plasma immunoreactive endothelin-1
levels among the three groups, patients with essential hypertension had
significantly higher plasma endothelin- 1 levels than normal subjects (2.29
+/- 1.09 vs. 1.41 +/- 0.50 pg/ml, p less than 0.025). When nondialyzed and
hemodialyzed patients were divided into hypertensive and normotensive
groups, the nondialyzed hypertensive group (n = 17) had higher plasma
endothelin-1 levels than the comparable normotensive group (n = 7) (3.08
+/- 3.43 vs. 0.73 +/- 0.34 pg/ml, p less than 0.05), and the hemodialyzed
hypertensive group (n = 18) had higher plasma endothelin-1 levels than the
comparable normotensive group (n = 33) (2.66 +/- 1.92 vs. 1.35 +/- 0.73
pg/ml, p less than 0.005). Plasma atrial natriuretic factor, arginine
vasopressin, renin activity, and aldosterone concentration did not show
significant differences between hypertensive and normotensive individuals
or a correlation with plasma endothelin-1 levels. These data suggest that
circulating endothelin-1 may be partly involved in the development or
maintenance of hypertension in humans.
ARTICLES
Plasma endothelin levels in hypertension and chronic renal failure
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
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