Hypertension, Vol 15, 519-527, Copyright © 1990 by American Heart Association
JE Hall, MW Brands, SD Kivlighn, HL Mizelle, DA Hildebrandt and CA Gaillard
Although hyperinsulinemia and increased adrenergic activity have been
postulated to be important factors in obesity-associated hypertension, a
cause and effect relation between insulin, catecholamines, and hypertension
has not been established. The aim of this study was to determine whether
chronic hyperinsulinemia, comparable with that found in obese hypertensive
patients, causes hypertension in normal dogs, increases plasma
catecholamines, or potentiates the blood pressure effects of
norepinephrine. In six normal dogs, insulin infusion (1.0
milliunits/kg/min) for 7 days, with euglycemia maintained, increased
fasting insulin fourfold to sixfold. However, mean arterial pressure did
not increase, averaging 99 +/- 2 mm Hg during the control period and 91 +/-
3 mm Hg during the 7 days of insulin infusion. Insulin did not alter plasma
norepinephrine or epinephrine, which averaged 171 +/- 27 and 71 +/- 14
pg/ml, respectively, during the control period and 188 +/- 29 and 45 +/- 12
pg/ml during the 7 days of insulin infusion. In six dogs, norepinephrine
was infused (0.2 microgram/kg/min) for 7 days to raise plasma
norepinephrine to 2,940 +/- 103 pg/ml. Insulin infusion (1.0
milliunits/kg/min) for 7 days during simultaneous infusion of
norepinephrine did not further increase mean arterial pressure, which
averaged 101 +/- 3 during norepinephrine and 98 +/- 2 mm Hg during insulin
plus norepinephrine infusion. Thus, chronic hyperinsulinemia did not
increase mean arterial pressure or plasma catecholamines and did not
potentiate the blood pressure actions of norepinephrine. These observations
provide no evidence that chronic hyperinsulinemia or interactions between
insulin and plasma catecholamines cause hypertension in normal dogs.
ARTICLES
Chronic hyperinsulinemia and blood pressure. Interaction with catecholamines?
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.
This article has been cited by other articles:
 |
|
 |
|
  M. W. Brands, T. D. Bell, N. A. Rodriquez, P. Polavarapu, and D. Panteleyev Chronic glucose infusion causes sustained increases in tubular sodium reabsorption and renal blood flow in dogs Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R265 - R271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Rocchini, J. Q. Yang, and A. Gokee Hypertension and Insulin Resistance Are Not Directly Related in Obese Dogs Hypertension, May 1, 2004; 43(5): 1011 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Kuo, O. B. Jones, and J. E. Hall Chronic cardiovascular and renal actions of leptin during hyperinsulinemia Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1037 - R1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Brands, A. E. Hailman, and S. M. Fitzgerald Long-Term Glucose Infusion Increases Arterial Pressure in Dogs With Cyclooxygenase-2 Inhibition Hypertension, February 1, 2001; 37(2): 733 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Rocchini, H. Z. Mao, K. Babu, P. Marker, and A. J. Rocchini Clonidine Prevents Insulin Resistance and Hypertension in Obese Dogs Hypertension, January 1, 1999; 33(1): 548 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-C. Huang, T.-C. Fang, and J.-T. Cheng Renal Denervation Prevents and Reverses Hyperinsulinemia-Induced Hypertension in Rats Hypertension, August 1, 1998; 32(2): 249 - 254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Keen, M. W. Brands, M. J. Smith Jr, and J. E. Hall Maintenance of Baseline Angiotensin II Potentiates Insulin Hypertension in Rats Hypertension, February 1, 1998; 31(2): 637 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. McKay and R. L. Hester Role of Nitric Oxide, Adenosine, and ATP-Sensitive Potassium Channels in Insulin-Induced Vasodilation Hypertension, August 1, 1996; 28(2): 202 - 208. [Abstract] [Full Text]
|
|
|
|
|
|
B. M. Egan, M. M.I. Hennes, K. T. Stepniakowski, I. M. O'Shaughnessy, A. H. Kissebah, and T. L. Goodfriend Obesity Hypertension Is Related More to Insulin's Fatty Acid Than Glucose Action Hypertension, March 1, 1996; 27(3): 723 - 728. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. M. Reaven, H. Lithell, and L. Landsberg Hypertension and Associated Metabolic Abnormalities -- The Role of Insulin Resistance and the Sympathoadrenal System N. Engl. J. Med., February 8, 1996; 334(6): 374 - 382. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Taddei, A. Virdis, P. Mattei, A. Natali, E. Ferrannini, and A. Salvetti Effect of Insulin on Acetylcholine-Induced Vasodilation in Normotensive Subjects and Patients With Essential Hypertension Circulation, November 15, 1995; 92(10): 2911 - 2918. [Abstract] [Full Text]
|
|
|
|
|
|
R. K. Davda, K. T. Stepniakowski, G. Lu, M. E. Ullian, T. L. Goodfriend, and B. M. Egan Oleic Acid Inhibits Endothelial Nitric Oxide Synthase by a Protein Kinase C-Independent Mechanism Hypertension, November 1, 1995; 26(5): 764 - 770. [Abstract] [Full Text]
|
|
|
|
|
|
J. Ribstein, G. du Cailar, and A. Mimran Combined Renal Effects of Overweight and Hypertension Hypertension, October 1, 1995; 26(4): 610 - 615. [Abstract] [Full Text]
|
|
|
|
|
|
R. J. Grekin, A. P. Vollmer, and R. S. Sider Pressor Effects of Portal Venous Oleate Infusion : A Proposed Mechanism for Obesity Hypertension Hypertension, July 1, 1995; 26(1): 193 - 198. [Abstract] [Full Text]
|
|
|
|
|
|
J. E. Hall, M. W. Brands, D. H. Zappe, W. N. Dixon, H. L. Mizelle, G. A. Reinhart, and D. A. Hildebrandt Hemodynamic and Renal Responses to Chronic Hyperinsulinemia in Obese, Insulin-Resistant Dogs Hypertension, May 1, 1995; 25(5): 994 - 1002. [Abstract] [Full Text]
|
|
|
|
|
|
T. Yamakawa, S.-i. Tanaka, K. Tamura, F. Isoda, K. Ukawa, Y. Yamakura, Y. Takanashi, Y. Kiuchi, S. Umemura, M. Ishii, et al. Wistar Fatty Rat Is Obese and Spontaneously Hypertensive Hypertension, January 1, 1995; 25(1): 146 - 150. [Abstract] [Full Text]
|
|