Hypertension, Vol 16, 252-260, Copyright © 1990 by American Heart Association
MA Adams, A Bobik and PI Korner
Three groups of spontaneously hypertensive rats (SHR) were given enalapril
(25 mg/kg/day) from 4 to 9 weeks, 4 to 14 weeks, and 14 to 20 weeks of age.
The drug was stopped and observations continued for another 16-21 weeks. At
selected times, we measured blood pressure, in vitro hindquarter vascular
resistance properties, left ventricular weight/body weight ratio, and
skeletal muscle vessel norepinephrine kinetics in treated and untreated SHR
and in Wistar-Kyoto (WKY) rats. At the end of each treatment period, all
cardiovascular variables were close to values of WKY rats and well below
those of untreated SHR, and the norepinephrine or fractional rate constant
was about 25% below those levels. After enalapril was stopped, blood
pressure and left ventricular weight/body weight ratio increased in
parallel to levels ranging from 30% to 50% of the normal difference between
untreated SHR and WKY rats. However, in SHR treated from 4 to 9 weeks and
from 4 to 14 weeks of age, hindquarter resistance properties remained close
to WKY rat levels for the entire observation period of 16-21 weeks after
treatment, suggesting suppression of the enhanced resistance responses of
SHR (amplifier properties). In SHR treated from 14 to 20 weeks of age,
suppression of amplifier properties was more transient, and they
redeveloped partially 5-6 weeks after cessation of therapy. When enalapril
was given up to 14 weeks of age, the long-term suppression of amplifier
properties was probably mainly through prevention of smooth muscle
hypertrophy in resistance vessels and possibly through other mechanisms
(e.g., "rarefaction").(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Enalapril can prevent vascular amplifier development in spontaneously hypertensive rats [published erratum appears in Hypertension 1991 Feb;17(2):262]
Baker Medical Research Institute, Melbourne, Australia.
This article has been cited by other articles:
 |
|
 |
|
  D. Behr-Roussel, D. Gorny, K. Mevel, S. Compagnie, P. Kern, V. Sivan, J. Bernabe, M. P. Bedigian, L. Alexandre, and F. Giuliano Erectile dysfunction: an early marker for hypertension? A longitudinal study in spontaneously hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R276 - R283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Smallegange, T. M. Hale, T. L. Bushfield, and M. A. Adams Persistent Lowering of Pressure by Transplanting Kidneys From Adult Spontaneously Hypertensive Rats Treated With Brief Antihypertensive Therapy Hypertension, July 1, 2004; 44(1): 89 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Smallegange, R. L. Kline, and M. A. Adams Transplantation of Enalapril-Treated Kidneys Confers Persistent Lowering of Arterial Pressure in SHR Hypertension, November 1, 2003; 42(5): 932 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Hale, M. J. Shoichet, T. L. Bushfield, and M. A. Adams Time Course of Vascular Structural Changes During and After Short-Term Antihypertensive Treatment Hypertension, August 1, 2003; 42(2): 171 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. NAKAYA, H. SASAMURA, M. HAYASHI, and T. SARUTA Temporary Treatment of Prepubescent Rats with Angiotensin Inhibitors Suppresses the Development of Hypertensive Nephrosclerosis J. Am. Soc. Nephrol., April 1, 2001; 12(4): 659 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Hollenberg Hypertension, Small Arteries, and Pathways for Angiotensin II Generation : "The Proper Study of Mankind is Man" Circulation, April 11, 2000; 101(14): 1641 - 1642. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zicha and J. Kunes Ontogenetic Aspects of Hypertension Development: Analysis in the Rat Physiol Rev, October 1, 1999; 79(4): 1227 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. W. Dukacz, M. A. Adams, and R. L. Kline Short- and long-term enalapril affect renal medullary hemodynamics in the spontaneously hypertensive rat Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R10 - R16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rizzoni, E. Porteri, A. Piccoli, M. Castellano, G. Bettoni, M. L. Muiesan, G. Pasini, D. Guelfi, M. J. Mulvany, and E. A. Rosei Effects of Losartan and Enalapril on Small Artery Structure in Hypertensive Rats Hypertension, August 1, 1998; 32(2): 305 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Dilley and M. I. Nataatmadja Heparin inhibits mesenteric vascular hypertrophy in angiotensin II-infusion hypertension in rats Cardiovasc Res, April 1, 1998; 38(1): 247 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsuchihashi, S. Kagiyama, Y. Ohya, I. Abe, and M. Fujishima Antihypertensive Treatment and the Responsiveness to Glutamate in Ventrolateral Medulla Hypertension, January 1, 1998; 31(1): 73 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. K. Gillies, M. Lu, H. Wang, and R. M. K. W. Lee AT1 Receptor Antagonist Treatment Caused Persistent Arterial Functional Changes in Young Spontaneously Hypertensive Rats Hypertension, December 1, 1997; 30(6): 1471 - 1478. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Banting, K. E. Thompson, P. Friberg, and M. A. Adams Blunted Cardiovascular Growth Induction During Prolonged Nitric Oxide Synthase Blockade Hypertension, September 1, 1997; 30(3): 416 - 421. [Abstract] [Full Text]
|
|
|
|
|
|
G. Guron, M. A. Adams, B. Sundelin, and P. Friberg Neonatal Angiotensin-Converting Enzyme Inhibition in the Rat Induces Persistent Abnormalities in Renal Function and Histology Hypertension, January 1, 1997; 29(1): 91 - 97. [Abstract] [Full Text]
|
|
|
|
|
|
W. Kiowski, L. Linder, R. Nuesch, and B. Martina Effects of Cilazapril on Vascular Structure and Function in Essential Hypertension Hypertension, March 1, 1996; 27(3): 371 - 376. [Abstract] [Full Text]
|
|
|
|
|
|
D. Rizzoni, M. Castellano, E. Porteri, G. Bettoni, M. L. Muiesan, A. Cinelli, and E. A. Rosei Effects of Low and High Doses of Fosinopril on the Structure and Function of Resistance Arteries Hypertension, July 1, 1995; 26(1): 118 - 123. [Abstract] [Full Text]
|
|
|
|
|
|
P. I. Korner and A. Bobik Cardiovascular Development After Enalapril in Spontaneously Hypertensive and Wistar-Kyoto Rats Hypertension, April 1, 1995; 25(4): 610 - 619. [Abstract] [Full Text]
|
|
|
|
|
|
M. M. Kett, D. Alcorn, J. F. Bertram, and W. P. Anderson Enalapril Does Not Prevent Renal Arterial Hypertrophy in Spontaneously Hypertensive Rats Hypertension, March 1, 1995; 25(3): 335 - 342. [Abstract] [Full Text]
|
|
|
|
|
|
J. B. O'Sullivan and S. B. Harrap Resetting Blood Pressure in Spontaneously Hypertensive Rats : The Role of Bradykinin Hypertension, February 1, 1995; 25(2): 162 - 165. [Abstract] [Full Text]
|
|