Hypertension, Vol 16, 363-370, Copyright © 1990 by American Heart Association
EG Erdos
Changes in our concepts of angiotensin I converting enzyme are reviewed
briefly. The actions of this enzyme go beyond liberating angiotensin II
from angiotensin I or inactivating bradykinin. Its very wide distribution
in the body and its activity in vitro indicate involvement in the
metabolism of other biologically active peptides. The recent molecular
cloning of the human enzyme confirmed the existence of a hydrophobic
C-terminal peptide that forms the short transmembrane domain of this plasma
membrane-bound enzyme. The much longer external portion contains two
homologous active site domains but probably only one functional active
center. Finally, in spite of the great progress made in studying
angiotensin converting enzyme, there are many challenging problems waiting
to be solved.
ARTICLES
Angiotensin I converting enzyme and the changes in our concepts through the years. Lewis K. Dahl memorial lecture
Laboratory of Peptide Research, University of Illinois College of Medicine, Chicago 60612.
This article has been cited by other articles:
 |
|
 |
|
  C. Mando, P. Antonazzo, S. Tabano, S. Zanutto, P. Pileri, E. Somigliana, F. Colleoni, A. Martinelli, A. Zolin, C. Benedetto, et al. Angiotensin-Converting Enzyme and Adducin-1 Polymorphisms in Women With Preeclampsia and Gestational Hypertension Reproductive Sciences, September 1, 2009; 16(9): 819 - 826. [Abstract] [PDF]
|
|
|
|
 |
|
 S.-k. Jung, J. Ra, J. Seo, H.-J. Jung, J.-Y. Choi, Y.-J. Cho, M.-S. Hong, J.-H. Chung, and J. Kim An Angiotensin I Converting Enzyme Polymorphism is Associated With Clinical Phenotype When Using Differentiation-Syndrome to Categorize Korean Bronchial Asthma Patients Evid. Based Complement. Altern. Med., June 12, 2009; (2009) nep053v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, O. A. Carretero, E. G. Shesely, N.-E. Rhaleb, J. J. Yang, M. Bader, and X.-P. Yang The kinin B1 receptor contributes to the cardioprotective effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in mice Exp Physiol, March 1, 2009; 94(3): 322 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hadjadj, F. Fumeron, R. Roussel, P.-J. Saulnier, Y. Gallois, A. Ankotche, F. Travert, C. A. Khalil, A. Miot, F. Alhenc-Gelas, et al. Prognostic Value of the Insertion/Deletion Polymorphism of the ACE Gene in Type 2 Diabetic Subjects: Results from the Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR), Diabete de type 2, Nephropathie et Genetique (DIAB2NEPHROGENE), and Survie, Diabete de type 2 et Genetique (SURDIAGENE) studies Diabetes Care, September 1, 2008; 31(9): 1847 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Arfa, A. Abid, S. Nouira, H. Elloumi-Zghal, D. Malouche, I. Mannai, M. M. Zorgati, N. Ben Alaya, A. Rebai, B. Zouari, et al. Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabetic nephropathy in Tunisian type 2 diabetic patients Journal of Renin-Angiotensin-Aldosterone System, March 1, 2008; 9(1): 32 - 36. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Zhou and W. F. Boron Role of endogenously secreted angiotensin II in the CO2-induced stimulation of HCO3 reabsorption by renal proximal tubules Am J Physiol Renal Physiol, January 1, 2008; 294(1): F245 - F252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kobori, M. Nangaku, L. G. Navar, and A. Nishiyama The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease Pharmacol. Rev., September 1, 2007; 59(3): 251 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gimenez, M. P. Garcia, M. Serna, B. Bonacasa, L. F. Carbonell, T. Quesada, and I. Hernandez 17{beta}-Oestradiol enhances the acute hypotensive effect of captopril in female ovariectomized spontaneously hypertensive rats Exp Physiol, July 1, 2006; 91(4): 715 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Camargo de Andrade, G. S. Di Marco, V. de Paulo Castro Teixeira, R. A. Mortara, R. A. Sabatini, J. B. Pesquero, M. A. Boim, A. K. Carmona, N. Schor, and D. E. Casarini Expression and localization of N-domain ANG I-converting enzymes in mesangial cells in culture from spontaneously hypertensive rats Am J Physiol Renal Physiol, February 1, 2006; 290(2): F364 - F375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. A. Carretero Novel mechanism of action of ACE and its inhibitors Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1796 - H1797. [Full Text] [PDF]
|
|
|
|
|
|
E. Kintsurashvili, A. Duka, I. Ignjacev, G. Pattakos, I. Gavras, and H. Gavras Age-related changes of bradykinin B1 and B2 receptors in rat heart Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H202 - H205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ozisik, M. Misirlioglu, T. A Ulus, S. Tuncer, M. Emir, and F. Katircioglu Renin-Angiotensin System Polymorphisms and Coronary Artery Surgery Patients Asian Cardiovasc Thorac Ann, June 1, 2005; 13(2): 153 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Tzakos, A. S. Galanis, G. A. Spyroulias, P. Cordopatis, E. Manessi-Zoupa, and I. P. Gerothanassis Structure-function discrimination of the N- and C- catalytic domains of human angiotensin-converting enzyme: implications for Cl- activation and peptide hydrolysis mechanisms Protein Eng. Des. Sel., December 1, 2003; 16(12): 993 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D.M. Marques, B. M.R. Quinto, F. L. Plavinik, J. E. Krieger, O. Marson, and D. E. Casarini N-Domain Angiotensin I-Converting Enzyme With 80 kDa as a Possible Genetic Marker of Hypertension Hypertension, October 1, 2003; 42(4): 693 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Meune, J.-J. Mourad, J.-F. Bergmann, and C. Spaulding Interaction between cyclooxygenase and the renin-angiotensin-aldosterone system: rationale and clinical relevance Journal of Renin-Angiotensin-Aldosterone System, September 1, 2003; 4(3): 149 - 154. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Georgiadis, F. Beau, B. Czarny, J. Cotton, A. Yiotakis, and V. Dive Roles of the Two Active Sites of Somatic Angiotensin-Converting Enzyme in the Cleavage of Angiotensin I and Bradykinin: Insights From Selective Inhibitors Circ. Res., July 25, 2003; 93(2): 148 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Skidgel, F. Alhenc-Gelas, and W. B. Campbell Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems: Prologue: Kinins and related systems. New life for old discoveries Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H1886 - H1891. [Full Text] [PDF]
|
|
|
|
|
|
J. Marchetti, C. M. B. Helou, C. Chollet, R. Rajerison, and F. Alhenc-Gelas Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems: ACE and non-ACE mediated effect of angiotensin I on intracellular calcium mobilization in rat glomerular arterioles Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H1933 - H1941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sangsree, V. Brovkovych, R. D. Minshall, and R. A. Skidgel Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems: Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H1959 - H1968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Campbell Vasopeptidase Inhibition: A Double-Edged Sword? Hypertension, March 1, 2003; 41(3): 383 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Dengel, M. D. Brown, R. E. Ferrell, T. H. Reynolds IV, and M. A. Supiano Exercise-induced changes in insulin action are associated with ACE gene polymorphisms in older adults Physiol Genomics, October 29, 2002; 11(2): 73 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kitakaze, H. Asanuma, H. Funaya, K. Node, S. Takashima, S. Sanada, M. Asakura, H. Ogita, J. Kim, and M. Hori Angiotensin-converting enzymeinhibitors and angiotensin iireceptor blockers synergistically increasecoronary blood flow in canine ischemic myocardium: Role of bradykinin J. Am. Coll. Cardiol., July 3, 2002; 40(1): 162 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Marin-Castano, J. P. Schanstra, E. Neau, F. Praddaude, C. Pecher, J.-L. Ader, J.-P. Girolami, and J.-L. Bascands Induction of Functional Bradykinin B1-Receptors in Normotensive Rats and Mice Under Chronic Angiotensin-Converting Enzyme Inhibitor Treatment Circulation, February 5, 2002; 105(5): 627 - 632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Navar, L. M. Harrison-Bernard, A. Nishiyama, and H. Kobori Regulation of Intrarenal Angiotensin II in Hypertension Hypertension, February 1, 2002; 39(2): 316 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Huang, Y. Gallois, N. Bouby, P. Bruneval, D. Heudes, M.-F. Belair, J. H. Krege, P. Meneton, M. Marre, O. Smithies, et al. Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse PNAS, October 25, 2001; (2001) 231476798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. van Dijk, G. Boner, S. Giler, and A. Erman Increased serum angiotensin-converting enzyme activity and plasma angiotensin II levels during pregnancy and postpartum in the diabetic rat Journal of Renin-Angiotensin-Aldosterone System, September 1, 2001; 2(3): 193 - 198. [Abstract] [PDF]
|
|
|
|
 |
|
 C. A. McKenzie, G. R. Abecasis, B. Keavney, T. Forrester, P. J. Ratcliffe, C. Julier, J. M.C. Connell, F. Bennett, N. McFarlane-Anderson, G. M. Lathrop, et al. Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE) Hum. Mol. Genet., May 1, 2001; 10(10): 1077 - 1084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Katoh, K. Egashira, C. Kataoka, M. Usui, M. Koyanagi, S. Kitamoto, Y. Ohmachi, A. Takeshita, and H. Narita Regression by ACE inhibition of arteriosclerotic changes induced by chronic blockade of NO synthesis in rats Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H2306 - H2312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L G. Navar, K. D Mitchell, L. M Harrison-Bernard, H. Kobori, and A. Nishiyama Review: Intrarenal angiotensin II levels in normal and hypertensive states Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S176 - S184. [PDF]
|
|
|
|
|
|
P. Meneton, M. Bloch-Faure, A. A. Hagege, H. Ruetten, W. Huang, S. Bergaya, D. Ceiler, D. Gehring, I. Martins, G. Salmon, et al. Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice PNAS, February 15, 2001; (2001) 51619598. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. W. Weinsaft, M. F. O'Rourke, W. W. Nichols, A. M. Sharma, T. Pischon, S. Engeli, H. Gavras, S. Yusuf, and G. S. Francis Effect of Ramipril on Cardiovascular Events in High-Risk Patients N. Engl. J. Med., July 6, 2000; 343(1): 64 - 66. [Full Text]
|
|
|
|
|
|
M. A. Hattori, G. L. Del Ben, A. K. Carmona, and D. E. Casarini Angiotensin I-Converting Enzyme Isoforms (High and Low Molecular Weight) in Urine of Premature and Full-Term Infants Hypertension, June 1, 2000; 35(6): 1284 - 1290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Junot, L. Nicolet, E. Ezan, M.-F. Gonzales, J. Menard, and M. Azizi Effect of Angiotensin-Converting Enzyme Inhibition on Plasma, Urine, and Tissue Concentrations of Hemoregulatory Peptide Acetyl-Ser-Asp-Lys-Pro in Rats J. Pharmacol. Exp. Ther., December 1, 1999; 291(3): 982 - 987. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. CHAGANI, P. D. PARÉ, S. ZHU, T. D. WEIR, T. R. BAI, N. A. BEHBEHANI, kJ. M. FITZGERALD, and A. J. SANDFORD Prevalence of Tumor Necrosis Factor-alpha and Angiotensin Converting Enzyme Polymorphisms in Mild/Moderate and Fatal/Near-Fatal Asthma Am. J. Respir. Crit. Care Med., July 1, 1999; 160(1): 278 - 282. [Abstract] [Full Text]
|
|
|
|
|
|
J. Xavier-Neto, A. C. Pereira, M. d. L. Junqueira, R. Carmona, and J. E. Krieger Rat Angiotensin-Converting Enzyme Promoter Regulation by {beta}-Adrenergics and cAMP in Endothelium Hypertension, July 1, 1999; 34(1): 31 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. Duncan, G. M. James, F. Anastasopoulos, A. Kladis, T. A. Briscoe, and D. J. Campbell Interaction Between Neutral Endopeptidase and Angiotensin Converting Enzyme Inhibition in Rats with Myocardial Infarction: Effects on Cardiac Hypertrophy and Angiotensin and Bradykinin Peptide Levels J. Pharmacol. Exp. Ther., April 1, 1999; 289(1): 295 - 303. [Abstract] [Full Text]
|
|
|
|
|
|
M. Azizi, E. Ezan, J.-L. Reny, J. Wdzieczak-Bakala, V. Gerineau, and J. Menard Renal and Metabolic Clearance of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (AcSDKP) During Angiotensin-Converting Enzyme Inhibition in Humans Hypertension, March 1, 1999; 33(3): 879 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Campbell, F. Anastasopoulos, A.-M. Duncan, G. M. James, A. Kladis, and T. A. Briscoe Effects of Neutral Endopeptidase Inhibition and Combined Angiotensin Converting Enzyme and Neutral Endopeptidase Inhibition on Angiotensin and Bradykinin Peptides in Rats J. Pharmacol. Exp. Ther., November 1, 1998; 287(2): 567 - 577. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. N. Atochina, I. V. Balyasnikova, S. M. Danilov, D. N. Granger, A. B. Fisher, and V. R. Muzykantov Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress Am J Physiol Lung Cell Mol Physiol, October 1, 1998; 275(4): L806 - L817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamada, S. N. Iyer, M. C. Chappell, D. Ganten, and C. M. Ferrario Converting Enzyme Determines Plasma Clearance of Angiotensin-(1–7) Hypertension, September 1, 1998; 32(3): 496 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Node, M. Kitakaze, H. Kosaka, T. Minamino, H. Mori, and M. Hori Role of Ca2+-Activated K+ Channels in the Protective Effect of ACE Inhibition Against Ischemic Myocardial Injury Hypertension, June 1, 1998; 31(6): 1290 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Huang, F. A. Gelas, and M. J. Osborne-Pellegrin Protection of the Arterial Internal Elastic Lamina by Inhibition of the Renin-Angiotensin System in the Rat Circ. Res., May 4, 1998; 82(8): 879 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Anastasopoulos, R. Leung, A. Kladis, G. M. James, T. A. Briscoe, T. P. Gorski, and D. J. Campbell Marked Difference between Angiotensin-Converting Enzyme and Neutral Endopeptidase Inhibition in Vivo by a Dual Inhibitor of Both Enzymes J. Pharmacol. Exp. Ther., March 1, 1998; 284(3): 799 - 805. [Abstract] [Full Text]
|
|
|
|
|
|
O. Costerousse, J. Allegrini, J.-P. Clozel, J. Ménard, and F. Alhenc-Gelas Angiotensin I-Converting Enzyme Inhibition but Not Angiotensin II Suppression Alters Angiotensin I-Converting Enzyme Gene Expression in Vessels and Epithelia J. Pharmacol. Exp. Ther., March 1, 1998; 284(3): 1180 - 1187. [Abstract] [Full Text]
|
|
|
|
|
|
M. Azizi, E. Ezan, L. Nicolet, J.-M. Grognet, and J. Menard High Plasma Level of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline : A New Marker of Chronic Angiotensin-Converting Enzyme Inhibition Hypertension, November 1, 1997; 30(5): 1015 - 1019. [Abstract] [Full Text]
|
|
|
|
|
|
E. N. ATOCHINA, V. R. MUZYKANTOV, A. B. AL-MEHDI, S. M. DANILOV, and A. B. FISHER Normoxic Lung Ischemia/Reperfusion Accelerates Shedding of Angiotensin Converting Enzyme from the Pulmonary Endothelium Am. J. Respir. Crit. Care Med., October 1, 1997; 156(4): 1114 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. TOMITA, Y. INA, Y. SUGIURA, S. SATO, H. KAWAGUCHI, M. MORISHITA, M. YAMAMOTO, and R. UEDA Polymorphism in the Angiotensin-Converting Enzyme (ACE) Gene and Sarcoidosis Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 255 - 259. [Abstract] [Full Text]
|
|
|
|
|
|
J. Bohlender, J. Menard, F. C. Luft, and D. Ganten Dose Effects of Human Renin in Rats Transgenic for Human Angiotensinogen Hypertension, April 1, 1997; 29(4): 1031 - 1038. [Abstract] [Full Text]
|
|
|
|
|
|
D. N. Muller, J. Bohlender, K. F. Hilgers, D. Dragun, O. Costerousse, J. Menard, and F. C. Luft Vascular Angiotensin-Converting Enzyme Expression Regulates Local Angiotensin II Hypertension, January 1, 1997; 29(1): 98 - 104. [Abstract] [Full Text]
|
|
|
|
|
|
P. Li, M. C. Chappell, C. M. Ferrario, and K. B. Brosnihan Angiotensin-(1-7) Augments Bradykinin-Induced Vasodilation by Competing With ACE and Releasing Nitric Oxide Hypertension, January 1, 1997; 29(1): 394 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-R. Kiema, H. Kauma, A. O. Rantala, M. Lilja, A. Reunanen, Y. A. Kesaniemi, and M. J. Savolainen Variation at the Angiotensin-Converting Enzyme Gene and Angiotensinogen Gene Loci in Relation to Blood Pressure Hypertension, December 1, 1996; 28(6): 1070 - 1075. [Abstract] [Full Text]
|
|
|
|
 |
|
 H.-H. Parving, P. Jacobsen, L. Tarnow, P. Rossing, L. Lecerf, O. Poirier, and F. Cambien Effect of deletion polymorphism of angiotensin converting enzyme gene on progression of diabetic nephropathy during inhibition of angiotensin converting enzyme: observational follow up study BMJ, September 7, 1996; 313(7057): 591 - 594. [Abstract] [Full Text]
|
|
|
|
|
|
F. Nakamura, R. D. Minshall, G. C. Le Breton, and S. F. Rabito Thromboxane A2 Mediates the Stimulation of Inositol 1,4,5-Trisphosphate Production and Intracellular Calcium Mobilization by Bradykinin in Neonatal Rat Ventricular Cardiomyocytes Hypertension, September 1, 1996; 28(3): 444 - 449. [Abstract] [Full Text]
|
|
|
|
|
|
N. J. Samani, J. R. Thompson, L. O'Toole, K. Channer, and K. L. Woods A Meta-analysis of the Association of the Deletion Allele of the Angiotensin-Converting Enzyme Gene With Myocardial Infarction Circulation, August 15, 1996; 94(4): 708 - 712. [Abstract] [Full Text]
|
|
|
|
|
|
K. B. Brosnihan, P. Li, and C. M. Ferrario Angiotensin-(1-7) Dilates Canine Coronary Arteries Through Kinins and Nitric Oxide Hypertension, March 1, 1996; 27(3): 523 - 528. [Abstract] [Full Text]
|
|
|
|
|
|
M. Kitakaze, T. Minamino, K. Node, K. Komamura, Y. Shinozaki, H. Mori, H. Kosaka, M. Inoue, M. Hori, and T. Kamada Beneficial Effects of Inhibition of Angiotensin-Converting Enzyme on Ischemic Myocardium During Coronary Hypoperfusion in Dogs Circulation, August 15, 1995; 92(4): 950 - 961. [Abstract] [Full Text]
|
|
|
|
|
|
V. Cachofeiro, R. Maeso, E. Rodrigo, J. Navarro, L. M. Ruilope, and V. Lahera Nitric Oxide and Prostaglandins in the Prolonged Effects of Losartan and Ramipril in Hypertension Hypertension, August 1, 1995; 26(2): 236 - 243. [Abstract] [Full Text]
|
|
|
|
|
|
M.-L. Lachurie, M. Azizi, T.-T. Guyene, F. Alhenc-Gelas, and J. Menard Angiotensin-Converting Enzyme Gene Polymorphism Has No Influence on the Circulating Renin-Angiotensin-Aldosterone System or Blood Pressure in Normotensive Subjects Circulation, June 15, 1995; 91(12): 2933 - 2942. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. J. Cornell, T. A.Williams, N. S. Lamango, D. Coates, P. Corvol, F. Soubrier, J. Hoheisel, H. Lehrach, and R. E. Isaac Cloning and Expression of an Evolutionary Conserved Single-domain Angiotensin Converting Enzyme from Drosophila melanogaster J. Biol. Chem., June 9, 1995; 270(23): 13613 - 13619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Minshall, F. Nakamura, R. P. Becker, and S. F. Rabito Characterization of Bradykinin B2 Receptors in Adult Myocardium and Neonatal Rat Cardiomyocytes Circ. Res., May 1, 1995; 76(5): 773 - 780. [Abstract] [Full Text]
|
|
|
|
|
|
M. Mai, K. F. Hilgers, J. Wagner, J. F. E. Mann, and H. Geiger Expression of Angiotensin-Converting Enzyme in Renovascular Hypertensive Rat Kidney Hypertension, April 1, 1995; 25(4): 674 - 678. [Abstract] [Full Text]
|
|
|
|
|
|
A. Rousseau, A. Michaud, M.-T.érès. Chauvet, M. Lenfant, and P. Corvol The Hemoregulatory Peptide N-Acetyl-Ser-Asp-Lys-Pro Is a Natural and Specific Substrate of the N-terminal Active Site of Human Angiotensin-converting Enzyme J. Biol. Chem., February 24, 1995; 270(8): 3656 - 3661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Mattu, E. W. A. Needham, D. J. Galton, E. Frangos, A. J. L. Clark, and M. Caulfield A DNA Variant at the Angiotensin-Converting Enzyme Gene Locus Associates With Coronary Artery Disease in the Caerphilly Heart Study Circulation, January 15, 1995; 91(2): 270 - 274. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. Kleinert, S. Rosenberg, W. Baker, H. Stein, V Klinghofer, J Barlow, K Spina, J Polakowski, P Kovar, J Cohen, et al. Discovery of a peptide-based renin inhibitor with oral bioavailability and efficacy Science, September 25, 1992; 257(5078): 1940 - 1943. [Abstract] [PDF]
|
|
|
|
|
|
P. Meneton, M. Bloch-Faure, A. A. Hagege, H. Ruetten, W. Huang, S. Bergaya, D. Ceiler, D. Gehring, I. Martins, G. Salmon, et al. Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice PNAS, February 27, 2001; 98(5): 2634 - 2639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Huang, Y. Gallois, N. Bouby, P. Bruneval, D. Heudes, M.-F. Belair, J. H. Krege, P. Meneton, M. Marre, O. Smithies, et al. Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse PNAS, November 6, 2001; 98(23): 13330 - 13334. [Abstract] [Full Text] [PDF]
|
|