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Hypertension, Vol 16, 484-490, Copyright © 1990 by American Heart Association
H Kanai, Y Matsuzawa, K Kotani, Y Keno, T Kobatake, Y Nagai, S Fujioka, K Tokunaga and S Tarui
The relation between intra-abdominal visceral fat accumulation and blood
pressure was investigated in 67 obese women (mean body mass index, 33.6 +/-
3.1; average age, 50 +/- 11 years). As an index of intra-abdominal fat
accumulation, the ratio of the intra-abdominal visceral fat area to
subcutaneous fat area was determined using a computed tomographic section
at the level of the umbilicus. When the obese subjects were divided into a
hypertensive group and a normotensive group, the ratio of the
intra-abdominal visceral fat area to subcutaneous fat area in the
hypertensive group was significantly higher (0.53 +/- 0.33 versus 0.29 +/-
0.12, p less than 0.01). Significant correlations between the ratio of
intra-abdominal visceral fat area to subcutaneous fat area and systolic
blood pressure (r = 0.62, p less than 0.001) and diastolic blood pressure
(r = 0.53, p less than 0.001) also were found. However, no significant
difference existed in either the body mass index or the waist-to-hip
circumference ratio between the hypertensive and normotensive groups.
Plasma renin activity, aldosterone, epinephrine, and norepinephrine levels
were not significantly different between the two groups. Moreover, the
correlation between the ratio of the intra-abdominal visceral fat area to
subcutaneous fat area ratio and blood pressure was found independent of age
and body mass index by multiple regression analyses. We conclude that
intra-abdominal fat accumulation itself may play an important role in the
pathogenesis of hypertension in obesity.
ARTICLES
Close correlation of intra-abdominal fat accumulation to hypertension in obese women
Second Department of Internal Medicine, Osaka University Medical School, Japan.
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