Hypertension, Vol 16, 515-522, Copyright © 1990 by American Heart Association
AS Brickman, MD Nyby, K von Hungen, P Eggena and ML Tuck
Plasma ionized calcium, platelet cytosolic calcium (using the fura-2 method
in gel-filtered platelets), parathyroid hormone (both the intact hormone
and a midmolecule portion), calcitriol, and calcidiol were measured in 19
untreated male patients with essential hypertension and 19 age-matched
normotensive male research subjects. Mean levels of platelet cytosolic
calcium, parathyroid hormone, calcitriol, and calcidiol were all
significantly higher, whereas plasma ionized calcium was significantly
lower, in the hypertensive group compared with the normotensive group. Both
platelet cytosolic calcium and intact parathyroid hormone were positively
correlated with mean arterial pressure (r = 0.58, p less than 0.001; r =
0.54, p less than 0.001, respectively), whereas plasma ionized calcium was
inversely correlated with mean arterial pressure (r = -0.60, p less than
0.001) in the combined group of all study subjects. All three of these
correlations were significant in the hypertensive group alone but not in
the normotensive group alone. When analyzed with plasma ionized calcium,
body mass index, serum calcitriol, and calcidiol in a multivariable
regression model, the significance of the partial regressions of platelet
cytosolic calcium and parathyroid hormone with mean arterial pressure
persisted. Intact parathyroid hormone was positively correlated to platelet
cytosolic calcium (r = 0.43, p less than 0.01) and plasma ionized calcium
was inversely correlated to platelet cytosolic calcium (r = -0.44, p less
than 0.01). These results confirm previous reports of disturbances of
calcium metabolism in essential hypertension and suggest that the elevated
platelet cytosolic calcium observed in essential hypertension may be linked
to one or more of these alterations of calcium metabolism.
ARTICLES
Calcitropic hormones, platelet calcium, and blood pressure in essential hypertension
Division of Endocrinology, Sepulveda Veterans Administration Medical Center, Calif.
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