Hypertension, Vol 16, 648-654, Copyright © 1990 by American Heart Association
D Gebremedhin, FJ Fenoy, DR Harder and RJ Roman
The renal microvascular responses of Wistar-Kyoto and spontaneously
hypertensive rats to changes in perfusion pressure were compared using a
juxtamedullary nephron microvascular preparation perfused in vitro with a
physiological salt solution containing 5% albumin. In the spontaneously
hypertensive rats, the internal diameters of arcuate and interlobular
arteries and the proximal and distal afferent arterioles averaged 307 +/-
26, 52 +/- 2, 24 +/- 0.9, and 22 +/- 1.2 microns, respectively, at 80 mm
Hg. They were 18-35% smaller (p less than 0.05) than the corresponding
vessels measured in Wistar-Kyoto rats. In low calcium media, the arcuate
and interlobular arteries and the proximal and distal afferent arterioles
of spontaneously hypertensive rats exhibited a greater dilation than the
vessels of Wistar-Kyoto rats. These observations suggest that the diameters
of the preglomerular vasculature of the spontaneously hypertensive rats are
reduced because of an elevated vascular tone rather than structural changes
narrowing the lumen of these vessels. These results suggest that enhanced
vascular tone in the preglomerular vasculature of juxtamedullary nephrons
may contribute to the elevated renal medullary vascular resistance and
resetting of the pressure-natriuretic relation previously observed in
spontaneously hypertensive rats.
ARTICLES
Enhanced vascular tone in the renal vasculature of spontaneously hypertensive rats
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
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