Hypertension, Vol 16, 712-717, Copyright © 1990 by American Heart Association
F Soubrier, X Jeunemaitre, B Rigat, AM Houot, F Cambien and P Corvol
A prospective study was conducted to compare the frequency of renin gene
polymorphisms in normotensive and hypertensive subjects. Hypertensive (n =
102, blood pressure 168 +/- 17/103 +/- 9 mm Hg) and normotensive (n = 120,
blood pressure 122 +/- 10/75 +/- 9 mm Hg) subjects were white, had similar
age and sex distributions (hypertensive group, 45 +/- 10 years old and 52%
female; normotensive group, 44 +/- 9 years old and 55% female) and similar
body mass index (hypertensive group, 23.2 +/- 2.6; normotensive group, 22.5
+/- 2.4 kg/m2, p = 0.048). The familial susceptibility to hypertension was
defined as at least one parent and one sibling who were hypertensive before
age 65; subjects in the normotensive group had no familial history of
hypertension. Renin gene polymorphisms located throughout the renin gene
were identified by using three restriction enzymes (Taq I, HinfI, HindIII).
For each polymorphic restriction site, allele frequencies were similar in
the hypertensive and the normotensive groups. In the absence of parental
genotypes, the haplotype frequencies combining the three restriction
fragment length polymorphisms were estimated by using maximum likelihood
techniques and were similar in both groups (hypertensive group, 0.429,
0.277, and 0.177; normotensive group, 0.453, 0.245, and 0.195 for the three
most common haplotypes). A rare haplotype detected by Taq I/Hind III was
apparently more frequent in the hypertensive than in the normotensive group
(hypertensive group, tH 0.086, th 0.022; normotensive group, tH 0.038, th
0.050), but the difference was not statistically significant. In
conclusion, no association between renin gene polymorphisms and essential
hypertension was demonstrated in the present study.
ARTICLES
Similar frequencies of renin gene restriction fragment length polymorphisms in hypertensive and normotensive subjects
INSERM U36 College de France, Paris.
This article has been cited by other articles:
 |
|
 |
|
  N. Moore, P. Dicker, J. K. O'Brien, M. Stojanovic, R. M. Conroy, A. Treumann, E. T. O'Brien, D. Fitzgerald, D. Shields, and A. V. Stanton Renin Gene Polymorphisms and Haplotypes, Blood Pressure, and Responses to Renin-Angiotensin System Inhibition Hypertension, August 1, 2007; 50(2): 340 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hasimu, T. Nakayama, Y. Mizutani, Y. Izumi, S. Asai, M. Soma, S. Kokubun, and Y. Ozawa Haplotype Analysis of the Human Renin Gene and Essential Hypertension Hypertension, February 1, 2003; 41(2): 308 - 312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jain, X. Tang, C. S. Narayanan, Y. Agarwal, S. M. Peterson, C. D. Brown, J. Ott, and A. Kumar Angiotensinogen Gene Polymorphism at -217 Affects Basal Promoter Activity and Is Associated with Hypertension in African-Americans J. Biol. Chem., September 20, 2002; 277(39): 36889 - 36896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Padmanabhan, S. Padmanabhan, and J. M. Connell Genetic basis of cardiovascular disease -- the renin-angiotensin-aldosterone system as a paradigm Journal of Renin-Angiotensin-Aldosterone System, December 1, 2000; 1(4): 316 - 324. [PDF]
|
|
|
|
|
|
T. Niu, X. Xu, H. J. Cordell, J. Rogus, Y. Zhou, Z. Fang, and K. Lindpaintner Linkage Analysis of Candidate Genes and Gene-Gene Interactions in Chinese Hypertensive Sib Pairs Hypertension, June 1, 1999; 33(6): 1332 - 1337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Davies, C. D. Holloway, M. C. Ingram, G. C. Inglis, E. C. Friel, C. Morrison, N. H. Anderson, R. Fraser, and J. M. C. Connell Aldosterone Excretion Rate and Blood Pressure in Essential Hypertension Are Related to Polymorphic Differences in the Aldosterone Synthase Gene CYP11B2 Hypertension, February 1, 1999; 33(2): 703 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fornage, C. I. Amos, S. Kardia, C. F. Sing, S. T. Turner, and E. Boerwinkle Variation in the Region of the Angiotensin-Converting Enzyme Gene Influences Interindividual Differences in Blood Pressure Levels in Young White Males Circulation, May 19, 1998; 97(18): 1773 - 1779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Muller, J. Bohlender, K. F. Hilgers, D. Dragun, O. Costerousse, J. Menard, and F. C. Luft Vascular Angiotensin-Converting Enzyme Expression Regulates Local Angiotensin II Hypertension, January 1, 1997; 29(1): 98 - 104. [Abstract] [Full Text]
|
|
|
|
|
|
N. Hubner, R. Kreutz, S. Takahashi, D. Ganten, and K. Lindpaintner Altered Angiotensinogen Amino Acid Sequence and Plasma Angiotensin II Levels in Genetically Hypertensive Rats : A Study on Cause and Effect Hypertension, August 1, 1995; 26(2): 279 - 284. [Abstract] [Full Text]
|
|
|
|
|
|
D. Lodwick, M. A. Kaiser, J. Harris, F. Cumin, M. Vincent, and N. J. Samani Analysis of the Role of Angiotensinogen in Spontaneous Hypertension Hypertension, June 1, 1995; 25(6): 1245 - 1251. [Abstract] [Full Text]
|
|
|
|
|
|
E. Haber Angiotensin-Converting Enzyme and Lipoprotein(a) as Risk Factors for Myocardial Infarction Circulation, March 15, 1995; 91(6): 1888 - 1890. [Full Text]
|
|
|
|
|
|
A. Bonnardeaux, S. Nadaud, A. Charru, X. Jeunemaitre, P. Corvol, and F. Soubrier Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension Circulation, January 1, 1995; 91(1): 96 - 102. [Abstract] [Full Text]
|
|
|
|
|
|
T. Nabika, A. Bonnardeaux, M. James, C. Julier, X. Jeunemaitre, P. Corvol, M. Lathrop, and F. Soubrier Evaluation of the SA Locus in Human Hypertension Hypertension, January 1, 1995; 25(1): 6 - 13. [Abstract] [Full Text]
|
|