Hypertension, Vol 17, 1152-1155, Copyright © 1991 by American Heart Association
K Hosoda, K Nakao, M Mukoyama, Y Saito, M Jougasaki, G Shirakami, S Suga, Y Ogawa, H Yasue and H Imura
To elucidate the expression of the brain natriuretic peptide gene in the
human heart, we have measured brain natriuretic peptide mRNA levels in
hearts using the Northern blot hybridization method. Brain natriuretic
peptide mRNA was present with a size of approximately 0.9 kb in the
ventricle as well as in the atrium. The brain natriuretic peptide mRNA
level in the ventricle was 52% of that in the atrium, whereas the atrial
natriuretic peptide mRNA level in the ventricle was approximately two
orders of magnitude lower than that in the atrium. Taking atrial and
ventricular weights into account, the total amount of brain natriuretic
peptide mRNA in the ventricle represented 77% of that in the whole heart.
These results demonstrate that most of brain natriuretic peptide mRNA
occurs in the ventricle, in contrast with atrial natriuretic peptide mRNA,
which is present mainly in the atrium, indicating that the ventricle is a
major production site of brain natriuretic peptide.
ARTICLES
Expression of brain natriuretic peptide gene in human heart. Production in the ventricle
Second Division, Kyoto University School of Medicine, Japan.
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