Hypertension, Vol 17, 888-895, Copyright © 1991 by American Heart Association
R Sarzani, G Arnaldi and AV Chobanian
Hypertension-associated growth of vascular smooth muscle cells might be
mediated in vivo by platelet-derived growth factor (PDGF). Our previous
investigations in hypertensive rats failed to demonstrate changes in aortic
steady-state mRNA levels of PDGF A or B chains. The current studies were
performed to determine whether hypertension might affect the expression of
PDGF receptors. We studied PDGF alpha- and beta- receptor gene expression
by Northern analysis using human and rat cDNA probes. Studies of tissue
distribution revealed that PDGF beta-receptor mRNA was most abundant in
total aorta and aortic media, whereas the PDGF alpha-receptor mRNA was most
abundant in the lung and was expressed at low levels in aortic tissue.
Deoxycorticosterone acetate (DOCA)-salt hypertension induced a threefold
increase in aortic steady- state PDGF beta-receptor mRNA levels. Aortic
PDGF beta-receptor expression also was higher in spontaneously hypertensive
rats (SHRs) when compared with age-matched normotensive Wistar-Kyoto (WKY)
controls. Aortic PDGF alpha-receptor steady-state mRNA levels were
unchanged in DOCA-salt hypertension and were expressed at similar levels in
WKY rats and SHRs. Unlike the findings with aorta, cardiac PDGF beta- and
alpha-receptor and PDGF B-chain expressions were unchanged in the DOCA-salt
model and were decreased in SHRs. These findings indicate that hypertension
can increase aortic steady-state mRNA levels for PDGF beta-receptor. They
also indicate that tissue- specific expression of the genes of the PDGF
ligand/receptor system are differentially regulated in hypertension.
ARTICLES
Hypertension-induced changes of platelet-derived growth factor receptor expression in rat aorta and heart
Whitaker Cardiovascular Institute, Boston, Mass.
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