Hypertension, Vol 17, 969-976, Copyright © 1991 by American Heart Association
SC Hunt, SH Stephenson, PN Hopkins and RR Williams
A prospective study on 1,482 adult members of 98 Utah pedigrees was carried
out to determine which variables may be associated with an increased risk
of hypertension incidence. After an average of 7 years of follow-up, 40
individuals had been placed on antihypertensive medications to lower blood
pressure. Baseline study variables included anthropometrics, clinical
chemistry measurements of blood and urine, socioeconomic and lifestyle
variables, and detailed erythrocyte ion transport and concentration
measurements. Age (relative risk of 4.28 for a 2 SD difference, p less than
0.0001) and baseline systolic and diastolic blood pressures (relative risks
of 3.55 and 3.52, respectively, both p less than 0.0001) had the strongest
associations with hypertension incidence. Controlling for age and baseline
blood pressure, the following age- and sex-adjusted variables were
associated with an increased risk of future hypertension (relative risks
for a 2 SD difference, all p less than 0.10): family history of
hypertension (2.35); height (1.97); body mass index (2.31); abdominal girth
(2.66); subscapular, suprailiac, and triceps skinfold thicknesses (2.79,
2.52, and 2.28, respectively); percent ideal body weight (2.63); log
triglyceride concentration (2.02); plasma uric acid (2.16); inorganic
phosphate (0.50); and passive erythrocyte sodium permeability (1.59). The
final model,which included all of the age- and sex-adjusted variables (p
less than 0.10) in a backward elimination logistic regression analysis,
consisted of age (4.78), systolic blood pressure (2.91), subscapular
skinfold thickness (2.21), height (1.92), uric acid (2.06), inorganic
phosphate (0.50), and family history of hypertension (1.82). None of the
ion transport or concentration measurements ws associated with an increased
risk of hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Predictors of an increased risk of future hypertension in Utah. A screening analysis
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
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