This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nabika, T. Articles by Yamori, Y. Search for Related Content PubMed PubMed Citation Articles by Nabika, T. Articles by Yamori, Y.

Hypertension, Vol 18, 12-16, Copyright © 1991 by American Heart Association

ARTICLES

Genetic heterogeneity of the spontaneously hypertensive rat

T Nabika, Y Nara, K Ikeda, J Endo and Y Yamori
Department of Laboratory Medicine, Shimane Medical University, Izumo, Japan.

We examined DNA fingerprints of the spontaneously hypertensive rat from Shimane Institute of Health Science, Izumo, Japan, including seven substrains that were separated in the early stages of the establishment of the stroke-prone spontaneously hypertensive rat, and compared their fingerprints with those of rats from other sources. Obtained DNA fingerprints revealed that, in both the stroke-resistant spontaneously hypertensive rat and the Wistar-Kyoto rat, there is a substantial genetic difference between the rats from the National Institutes of health and from Shimane Institute of Health Science. By contrast, only a small genetic difference was observed either between the rats from the National Institutes of Health and Charles River Laboratories or among the substrains of the spontaneously hypertensive rat in the Shimane Institute of Health Science. Further, in the strains from the Shimane Institute of Health Science, there were fingerprinting bands that could distinguish either the Wistar-Kyoto rat from all the substrains of the spontaneously hypertensive rat or the stroke-prone from the stroke-resistant spontaneously hypertensive rat in spite of their close genetic backgrounds. From the observations above, we concluded 1) that there is substantial genetic variance of the spontaneously hypertensive rat between the two major sources in the world, the National Institutes of Health and the Shimane Institute of Health Science and 2) that by DNA fingerprinting analysis, it is possible to identify the restriction fragment length polymorphisms that are specific for the spontaneously hypertensive rat or the stroke-prone spontaneously hypertensive rat. These polymorphisms can be applied in the segregation study of the F2 generation.

This article has been cited by other articles:

				Y. Ochiai, Y.-Q. Liang, M. Serizawa, and N. Kato Dynamic changes of the renin-angiotensin and associated systems in the rat after pharmacological and dietary interventions in vivo Physiol Genomics, November 12, 2008; 35(3): 330 - 340. [Abstract] [Full Text] [PDF]

				K. Goto, K. Fujii, U. Onaka, I. Abe, and M. Fujishima Renin-Angiotensin System Blockade Improves Endothelial Dysfunction in Hypertension Hypertension, October 1, 2000; 36(4): 575 - 580. [Abstract] [Full Text] [PDF]

				N. Kato, T. Tamada, T. Nabika, K. Ueno, T. Gotoda, C. Matsumoto, T. Mashimo, M. Sawamura, K. Ikeda, Y. Nara, et al. Identification of Quantitative Trait Loci for Serum Cholesterol Levels in Stroke-Prone Spontaneously Hypertensive Rats Arterioscler Thromb Vasc Biol, January 1, 2000; 20(1): 223 - 229. [Abstract] [Full Text] [PDF]

				J. P. Rapp Genetic Analysis of Inherited Hypertension in the Rat Physiol Rev, January 1, 2000; 80(1): 135 - 172. [Abstract] [Full Text] [PDF]

				J. Zicha and J. Kunes Ontogenetic Aspects of Hypertension Development: Analysis in the Rat Physiol Rev, October 1, 1999; 79(4): 1227 - 1282. [Abstract] [Full Text] [PDF]

				H. Cai, H. Yao, S. Ibayashi, H. Uchimura, M. Fujishima, and B. D. Watson Photothrombotic Middle Cerebral Artery Occlusion in Spontaneously Hypertensive Rats: Influence of Substrain, Gender, and Distal Middle Cerebral Artery Patterns on Infarct Size • Editorial Comment Stroke, September 1, 1998; 29(9): 1982 - 1987. [Abstract] [Full Text] [PDF]

				U. Onaka, K. Fujii, I. Abe, and M. Fujishima Antihypertensive Treatment Improves Endothelium-Dependent Hyperpolarization in the Mesenteric Artery of Spontaneously Hypertensive Rats Circulation, July 14, 1998; 98(2): 175 - 182. [Abstract] [Full Text] [PDF]

				Y. Ohya, T. Tsuchihashi, S. Kagiyama, I. Abe, and M. Fujishima Single L-Type Calcium Channels in Smooth Muscle Cells From Resistance Arteries of Spontaneously Hypertensive Rats Hypertension, May 1, 1998; 31(5): 1125 - 1129. [Abstract] [Full Text] [PDF]

				S. Kagiyama, T. Tsuchihashi, I. Abe, and M. Fujishima Enhanced Depressor Response to Nitric Oxide in the Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats Hypertension, April 1, 1998; 31(4): 1030 - 1034. [Abstract] [Full Text] [PDF]

				T. Yoshimoto, M. Naruse, A. Tanabe, K. Naruse, T. Seki, T. Imaki, T. Muraki, Y. Matsuda, and H. Demura Potentiation of Natriuretic Peptide Action by the {beta}-Adrenergic Blocker Carvedilol in Hypertensive Rats: A New Antihypertensive Mechanism Endocrinology, January 1, 1998; 139(1): 81 - 88. [Abstract] [Full Text] [PDF]

				T. Tsuchihashi, S. Kagiyama, Y. Ohya, I. Abe, and M. Fujishima Antihypertensive Treatment and the Responsiveness to Glutamate in Ventrolateral Medulla Hypertension, January 1, 1998; 31(1): 73 - 76. [Abstract] [Full Text] [PDF]

				J. S. Clark, B. Jeffs, A. O. Davidson, W. K. Lee, N. H. Anderson, M.-T. Bihoreau, M. J. Brosnan, A. M. Devlin, A. W. Kelman, K. Lindpaintner, et al. Quantitative Trait Loci in Genetically Hypertensive Rats: Possible Sex Specificity Hypertension, November 1, 1996; 28(5): 898 - 906. [Abstract] [Full Text]

				P. I. Korner and A. Bobik Cardiovascular Development After Enalapril in Spontaneously Hypertensive and Wistar-Kyoto Rats Hypertension, April 1, 1995; 25(4): 610 - 619. [Abstract] [Full Text]