This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by O'Dowd, B. F. Articles by Rapp, J. P. Search for Related Content PubMed PubMed Citation Articles by O'Dowd, B. F. Articles by Rapp, J. P.

Hypertension, Vol 18, 9-11, Copyright © 1991 by American Heart Association

ARTICLES

Heterogeneity of renin alleles in outbred Dahl salt-sensitive (Brookhaven) rats

BF O'Dowd and JP Rapp
Department of Pharmacology, University of Toronto, Canada.

Selectively outbred Dahl salt-sensitive (DS) and salt-resistant (DR) rats were compared with the inbred Dahl salt-sensitive (SS/Jr) and salt- resistant (SR/Jr) rats developed from the original Brookhaven stocks by J.P. Rapp. The animals were evaluated for genotype at the renin locus. The inbred strains are uniformly homozygous for their respective alleles, s in SS/Jr and r in SR/Jr. DR rats were also uniformly homozygous for the r renin allele. In DS rats, however, three renin alleles were segregating. In addition to the s and r alleles, a third allele, designated the z allele, was found. The gene frequencies in DS rats were s = 0.690, r = 0.284, and z = 0.026. Continued use of DS and DR rats in most experimental work is inappropriate because of genetic heterogeneity in the DS stock.