Hypertension, Vol 18, 630-635, Copyright © 1991 by American Heart Association
GM Reaven, J Twersky and H Chang
Plasma glucose, insulin, and triglyceride concentration, blood pressure,
and insulin action on isolated adipocytes were determined in weight-matched
Sprague-Dawley, Dahl salt-resistant, and Dahl salt- sensitive rats. Blood
pressure and plasma glucose concentrations were not significantly different
in the three groups. However, Dahl salt- sensitive rats had significantly
higher plasma insulin (39 +/- 2 microunits/ml) and triglyceride (213 +/- 11
mg/dl) concentrations than did Sprague-Dawley rats (27 +/- 2 microunits/ml
and 101 +/- 6 mg/dl, respectively). Values for insulin (34 +/- 4
microunits/ml) and triglyceride (159 +/- 11 mg/dl) were intermediate in
Dahl salt- resistant rats. In contrast, maximal insulin-stimulated glucose
transport was significantly lower in adipocytes isolated from Dahl salt-
sensitive as compared with Sprague-Dawley rats (400 +/- 16 versus 523 +/-
14 fl/cell/sec), with Dahl salt-resistant rats again having intermediate
values. However, the ability of insulin to maximally inhibit
catecholamine-stimulated lipolysis was similar in all three groups,
averaging approximately 20% of the activity present in the absence of
insulin. All of these differences were seen when the rats were eating
conventional chow and did not change in Dahl rats after 2 weeks of an 8%
NaCl diet. On the other hand, the predicted rise in blood pressure took
place in Dahl salt-sensitive rats, increasing from 147 +/- 4 to 181 +/- 6
mm Hg.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Abnormalities of carbohydrate and lipid metabolism in Dahl rats
Department of Medicine, Stanford University School of Medicine, Palo Alto, Calif.
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