Hypertension, Vol 18, 722-727, Copyright © 1991 by American Heart Association
KL Christensen
To investigate the relation between the small artery structure and
different blood pressure parameters, spontaneously hypertensive rats were
treated from 4 to 24 weeks of age (20 weeks in total) with five different
antihypertensive therapies: two angiotensin converting enzyme inhibitors
(perindopril and captopril), a calcium antagonist (isradipine), a
beta-blocker (metoprolol), and a vasodilator (hydralazine). At 24 weeks of
age, 24-hour blood pressure was measured, and two mesenteric resistance
vessels were taken from each animal. Blood pressure was 227/135 mm Hg
(systolic/diastolic) and 161/106 mm Hg in untreated hypertensive and
normotensive control rats, respectively. Heart rates were 376 min-1 and 295
min-1 for the two strains. All treatments reduced all blood pressure
parameters except for metoprolol, which did not reduce pulse pressure. In
the small arteries, the media cross-sectional area was unaffected by the
treatments. When a simple correlation analysis was made, pulse pressure was
found to correlate more closely (r = 0.64, p less than 0.001) to the
resistance vessel media/lumen ratio than any of the other pressure
parameters studied: systolic (r = 0.51, p = 0.011), mean (r = 0.41, p =
0.05), or diastolic (r = 0.28, p = 0.19). When an analysis of covariance
was performed that included pulse pressure, mean blood pressure, and heart
rate, which also correlated significantly to the media/lumen ratio, 81% of
the variation in the media/lumen ratio could be accounted for by the
variation in the three covariates (p less than 10(-5)), pulse pressure
being the major factor.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Reducing pulse pressure in hypertension may normalize small artery structure
Biophysics Institute, University of Aarhus, Denmark.
This article has been cited by other articles:
 |
|
 |
|
  G. F. Mitchell Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage J Appl Physiol, November 1, 2008; 105(5): 1652 - 1660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. F. Mitchell, P. R. Conlin, M. E. Dunlap, Y. Lacourciere, J. M. O. Arnold, R. I. Ogilvie, J. Neutel, J. L. Izzo Jr, and M. A. Pfeffer Aortic Diameter, Wall Stiffness, and Wave Reflection in Systolic Hypertension Hypertension, January 1, 2008; 51(1): 105 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Serne, R. T. de Jongh, E. C. Eringa, R. G. IJzerman, and C. D.A. Stehouwer Microvascular Dysfunction: A Potential Pathophysiological Role in the Metabolic Syndrome Hypertension, July 1, 2007; 50(1): 204 - 211. [Full Text] [PDF]
|
|
|
|
 |
|
 G. F. Mitchell, J. A. Vita, M. G. Larson, H. Parise, M. J. Keyes, E. Warner, R. S. Vasan, D. Levy, and E. J. Benjamin Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness: The Framingham Heart Study Circulation, December 13, 2005; 112(24): 3722 - 3728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Panagiotakos, D. Kromhout, A. Menotti, C. Chrysohoou, A. Dontas, C. Pitsavos, H. Adachi, H. Blackburn, S. Nedeljkovic, and A. Nissinen The Relation Between Pulse Pressure and Cardiovascular Mortality in 12 763 Middle-aged Men From Various Parts of the World: A 25-Year Follow-up of the Seven Countries Study Arch Intern Med, October 10, 2005; 165(18): 2142 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Vita, J. F. Keaney Jr, M. G. Larson, M. J. Keyes, J. M. Massaro, I. Lipinska, B. T. Lehman, S. Fan, E. Osypiuk, P. W.F. Wilson, et al. Brachial Artery Vasodilator Function and Systemic Inflammation in the Framingham Offspring Study Circulation, December 7, 2004; 110(23): 3604 - 3609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Baumbach, C. D. Sigmund, and F. M. Faraci Structure of Cerebral Arterioles in Mice Deficient in Expression of the Gene for Endothelial Nitric Oxide Synthase Circ. Res., October 15, 2004; 95(8): 822 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Mitchell, H. Parise, J. A. Vita, M. G. Larson, E. Warner, J. F. Keaney Jr, M. J. Keyes, D. Levy, R. S. Vasan, and E. J. Benjamin Local Shear Stress and Brachial Artery Flow-Mediated Dilation: The Framingham Heart Study Hypertension, August 1, 2004; 44(2): 134 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. N. T. P. Bakker, O. Sorop, J. A. E. Spaan, and E. VanBavel Remodeling of resistance arteries in organoid culture is modulated by pressure and pressure pulsation and depends on vasomotion Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2052 - H2056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Chillon and G. L. Baumbach Effects of Indapamide, a Thiazide-Like Diuretic, on Structure of Cerebral Arterioles in Hypertensive Rats Hypertension, May 1, 2004; 43(5): 1092 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E N T P Bakker, J P Versluis, P Sipkema, J W G E VanTeeffelen, T M Rolf, J A E Spaan, and E VanBavel Differential structural adaptation to haemodynamics along single rat cremaster arterioles J. Physiol., April 15, 2003; 548(2): 549 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Haider, M. G. Larson, S. S. Franklin, and D. Levy Systolic Blood Pressure, Diastolic Blood Pressure, and Pulse Pressure as Predictors of Risk for Congestive Heart Failure in the Framingham Heart Study Ann Intern Med, January 7, 2003; 138(1): 10 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Safar, J. Blacher, J. J. Mourad, and G. M. London Stiffness of Carotid Artery Wall Material and Blood Pressure in Humans : Application to Antihypertensive Therapy and Stroke Prevention Stroke, March 1, 2000; 31(3): 782 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zicha and J. Kunes Ontogenetic Aspects of Hypertension Development: Analysis in the Rat Physiol Rev, October 1, 1999; 79(4): 1227 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Franklin, S. A. Khan, N. D. Wong, M. G. Larson, and D. Levy Is Pulse Pressure Useful in Predicting Risk for Coronary Heart Disease? : The Framingham Heart Study Circulation, July 27, 1999; 100(4): 354 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Verdecchia, G. Schillaci, C. Borgioni, A. Ciucci, S. Pede, and C. Porcellati Ambulatory Pulse Pressure : A Potent Predictor of Total Cardiovascular Risk in Hypertension Hypertension, December 1, 1998; 32(6): 983 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Gaballa, C. T. Jacob, T. E. Raya, J. Liu, B. Simon, and S. Goldman Large Artery Remodeling During Aging : Biaxial Passive and Active Stiffness Hypertension, September 1, 1998; 32(3): 437 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Dickhout and R. M. K. W. Lee Blood pressure and heart rate development in young spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H794 - H800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Moreau, L. V d'Uscio, and T. F Luscher Structure and reactivity of small arteries in aging Cardiovasc Res, January 1, 1998; 37(1): 247 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Mitchell, L. A. Moye, E. Braunwald, J.-L. Rouleau, V. Bernstein, E. M. Geltman, G. C. Flaker, M. A. Pfeffer, and f. t. S. Investigators Sphygmomanometrically Determined Pulse Pressure Is a Powerful Independent Predictor of Recurrent Events After Myocardial Infarction in Patients With Impaired Left Ventricular Function Circulation, December 16, 1997; 96(12): 4254 - 4260. [Abstract] [Full Text]
|
|
|
|
|
|
J.-M. Chillon, S. Ghoneim, and G. L. Baumbach Effects of Chronic Nitric Oxide Synthase Inhibition on Cerebral Arterioles in Rats Hypertension, November 1, 1997; 30(5): 1097 - 1104. [Abstract] [Full Text]
|
|
|
|
|
|
C. R. Galarza, J. Alfie, G. D. Waisman, L. M. Mayorga, L. A. Camera, M. del Rio, F. Vasvari, R. Limansky, J. Farias, J. Tessler, et al. Diastolic Pressure Underestimates Age-Related Hemodynamic Impairment Hypertension, October 1, 1997; 30(4): 809 - 816. [Abstract] [Full Text]
|
|
|
|
|
|
J.-M. Chillon, D. D. Heistad, and G. L. Baumbach Effects of Endothelin Receptor Inhibition on Cerebral Arterioles in Hypertensive Rats Hypertension, March 1, 1996; 27(3): 794 - 798. [Abstract] [Full Text]
|
|
|
|
|
|
R. Weber, N. Stergiopulos, H. R. Brunner, and D. Hayoz Contributions of Vascular Tone and Structure to Elastic Properties of a Medium-Sized Artery Hypertension, March 1, 1996; 27(3): 816 - 822. [Abstract] [Full Text]
|
|
|
|
|
|
G. L. Baumbach Effects of Increased Pulse Pressure on Cerebral Arterioles Hypertension, February 1, 1996; 27(2): 159 - 167. [Abstract] [Full Text]
|
|
|
|
|
|
S. G. Blank, S. J. Mann, G. D. James, J. E. West, and T. G. Pickering Isolated Elevation of Diastolic Blood Pressure : Real or Artifactual? Hypertension, September 1, 1995; 26(3): 383 - 389. [Abstract] [Full Text]
|
|
|
|
|
|
D. D. Heistad, M. L. Armstrong, G. L. Baumbach, and F. M. Faraci Sick Vessel Syndrome : Recovery of Atherosclerotic and Hypertensive Vessels Hypertension, September 1, 1995; 26(3): 509 - 513. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. James, P. A. C. Watt, J. F. Potter, H. Thurston, and J. D. Swales Pulse Pressure and Resistance Artery Structure in the Elderly Hypertension, August 1, 1995; 26(2): 301 - 306. [Abstract] [Full Text]
|
|
|
|
|
|
P. B. Dobrin Mechanical Factors Associated With the Development of Intimal and Medial Thickening in Vein Grafts Subjected to Arterial Pressure : A Model of Arteries Exposed to Hypertension Hypertension, July 1, 1995; 26(1): 38 - 43. [Abstract] [Full Text]
|
|
|
|
|
|
R. S. Vasan, M. G. Larson, and D. Levy Determinants of Echocardiographic Aortic Root Size : The Framingham Heart Study Circulation, February 1, 1995; 91(3): 734 - 740. [Abstract] [Full Text]
|
|