Hypertension, Vol 18, 783-789, Copyright © 1991 by American Heart Association
B Andersson, M Elam, BG Wallin, P Bjorntorp and OK Andersson
Twenty obese women aged 45-65 years with borderline hypertension were
allocated randomly to either a group with an energy-restricted diet or to a
control group. Body weight, blood pressure, urinary sodium, and urinary
excretion of norepinephrine and plasma volume were recorded. Resting muscle
sympathetic nerve activity was measured in the peroneal nerve by tungsten
microelectrodes and expressed as bursts per minute. These measurements were
repeated after 3 days of semistarvation and after a body weight reduction
of 7% while each patient's weight was in a steady state. After 3 days of
semistarvation, only body weight was reduced, whereas after the long-term
energy intake restriction, there were reductions of body weight (79.9 +/-
3.4 versus 74.1 +/- 3.4 kg; p less than 0.001), diastolic blood pressure
(93 +/- 3 versus 86 +/- 4 mm Hg; p = 0.01), and muscle sympathetic nerve
activity (49 +/- 2 versus 42 +/- 3 bursts/min; p less than 0.05). Other
variables were unchanged. There were no changes in body weight, blood
pressure, or muscle sympathetic nerve activity in the control group. We
conclude that body weight decrease in obesity results in a reduction of
blood pressure that is at least partially caused by a reduction of
sympathetic vasoconstrictor activity.
ARTICLES
Effect of energy-restricted diet on sympathetic muscle nerve activity in obese women
Department of Internal Medicine I, School of Medicine, University of Gothenburg, Sahlgren's Hospital, Sweden.
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