Hypertension, Vol 18, 805-812, Copyright © 1991 by American Heart Association
VM Campese, M Parise, F Karubian and R Bigazzi
African-Americans with essential hypertension are more prone to the
development of renal failure and are frequently salt-sensitive as well.
Because alterations of intrarenal hemodynamics are important in the
progression of renal disease and because salt-sensitive animal models with
hypertension manifest a greater propensity to develop glomerulosclerosis in
association with a rise in glomerular capillary pressure, we tested whether
the renal hemodynamic adaptation to high dietary Na+ intake differs in
salt-sensitive and salt-resistant hypertensive patients. We studied 17
black and nine white patients with essential hypertension who were placed
on a low Na+ diet (20 meq/day) for 9 days, followed by a high Na+ diet (200
meq/day) for 14 days. During the last 4 days of each diet regimen, they
received 30 mg/day of slow-release nifedipine. Eleven blacks were
salt-sensitive, and all whites were salt-resistant. During the low Na+ diet
period, salt- sensitive and salt-resistant patients had similar mean
arterial pressure, glomerular filtration rate, effective renal plasma flow,
and filtration fraction.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Abnormal renal hemodynamics in black salt-sensitive patients with hypertension
Department of Medicine, University of Southern California Medical Center, Los Angeles 90033.
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