Hypertension, Vol 19, 117-130, Copyright © 1992 by American Heart Association
TF Luscher, CM Boulanger, Y Dohi and ZH Yang
The endothelium not only mediates relaxation but is a source of contracting
factors. Endothelium-dependent contractions are elicited by physical and
chemical stimuli (i.e., hypoxia, pressure, and stretch) and autacoids,
local and circulating hormones. The mechanism of endothelium-dependent
contractions to hypoxia involves withdrawal of nitric oxide. The
endothelial cyclooxygenase pathway can produce thromboxane A2,
prostaglandin H2, and superoxide anions. The peptide endothelin is a potent
contracting factor; its production is stimulated by vasopressor hormones,
platelet-derived factors, coagulation products, and cytokines, whereas
endothelium-derived nitric oxide, prostacyclin, and a smooth muscle
cell-derived inhibitory factor reduce endothelin production. In
hypertension, the release of cyclooxygenase- dependent endothelium-derived
contracting factors to stretch, acetylcholine, and platelet-derived
products is augmented. Vascular endothelin production in hypertension
remains controversial but appears mostly normal; it is augmented in the
presence of vascular disease or renal insufficiency. The
endothelium-dependent inhibition of endothelin- induced contractions is
reduced in hypertension while the reactivity of vascular smooth muscle may
be normal, increased, or reduced. The potentiating effects of low
concentrations of endothelin on contractions to norepinephrine are
augmented with aging and hypertension. In atherosclerosis, the production
of the cyclooxygenase- dependent endothelium-derived contracting factors
and endothelin is enhanced. Thus, endothelium-derived contracting factors
can profoundly affect vascular tone and counteract relaxing factors
produced within the endothelium. In hypertension and atherosclerosis, the
role of contracting factors appears to become more dominant, leading to an
imbalance of endothelium-dependent vascular regulation.
ARTICLES
Endothelium-derived contracting factors
Department of Medicine, University Hospital, Basel, Switzerland.
This article has been cited by other articles:
 |
|
 |
|
  G. Burnstock Endothelium-Derived Vasoconstriction by Purines and Pyrimidines Circ. Res., November 7, 2008; 103(10): 1056 - 1057. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Michelson, J. Harazny, R. E. Schmieder, R. Berendes, T. Fiermann, and S. Warntges Response to Analysis of Carotid and Ophthalmic Flow Velocity Waveforms Hypertension, March 1, 2008; 51(3): e19 - e19. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Mayahi, S. Heales, D. Owen, J. P. Casas, J. Harris, R. J. MacAllister, and A. D. Hingorani (6R)-5,6,7,8-Tetrahydro-L-Biopterin and Its Stereoisomer Prevent Ischemia Reperfusion Injury in Human Forearm Arterioscler Thromb Vasc Biol, June 1, 2007; 27(6): 1334 - 1339. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Ding and P. A. Murray Regulation of pulmonary venous tone in response to muscarinic receptor activation Am J Physiol Lung Cell Mol Physiol, January 1, 2005; 288(1): L131 - L140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Goto, N. M Rummery, T. H. Grayson, and C. E Hill Attenuation of conducted vasodilatation in rat mesenteric arteries during hypertension: role of inwardly rectifying potassium channels J. Physiol., November 15, 2004; 561(1): 215 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-C. Juan, Y.-W. Shen, Y. Chien, Y.-J. Lin, S.-F. Chang, and L.-T. Ho Insulin infusion induces endothelin-1-dependent hypertension in rats Am J Physiol Endocrinol Metab, November 1, 2004; 287(5): E948 - E954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. I. Sokol, E. L. Portnay, J. P. Curtis, M. A. Nelson, P. R. Hebert, J. F. Setaro, and J. M. Foody Modulation of the renin-angiotensin-aldosterone system for the secondary prevention of stroke Neurology, July 27, 2004; 63(2): 208 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Q. Liu and R. J. Folz Extracellular superoxide enhances 5-HT-induced murine pulmonary artery vasoconstriction Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L111 - L118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Houghton, D. S. Strogatz, M. T. Torosoff, V. E. Smith, S. A. Fein, P. A. Kuhner, E. F. Philbin, and A. A. Carr African Americans With LVH Demonstrate Depressed Sensitivity of the Coronary Microcirculation to Stimulated Relaxation Hypertension, September 1, 2003; 42(3): 269 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Q. Liu, J. S. K. Sham, L. A. Shimoda, P. Kuppusamy, and J. T. Sylvester Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L322 - L333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Belhassen, G. Pelle, J.-L. Dubois-Rande, and S. Adnot Improved endothelial function by the thromboxane a2 receptor antagonist s 18886 in patients with coronary artery disease treated with aspirin J. Am. Coll. Cardiol., April 2, 2003; 41(7): 1198 - 1204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Hurlimann, F. Ruschitzka, and T.F. Luscher The relationship between the endothelium and the vessel wall Eur. Heart J. Suppl., February 1, 2002; 4(suppl_A): A1 - A7. [Abstract] [PDF]
|
|
|
|
 |
|
 M. F. Wright, B. Sayre, E. Keith Inskeep, and J. A. Flores Prostaglandin F2{alpha} Regulation of the Bovine Corpus Luteum Endothelin System During the Early and Midluteal Phase Biol Reprod, December 1, 2001; 65(6): 1710 - 1717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Engler and M. M. Engler Docosahexaenoic Acid-Induced Vasorelaxation in Hypertensive Rats: Mechanisms of Action Biol Res Nurs, October 1, 2000; 2(2): 85 - 95. [Abstract] [PDF]
|
|
|
|
 |
|
 W. Ayub and S. Fletcher End-stage renal disease and erectile dysfunction. Is there any hope? Nephrol. Dial. Transplant., October 1, 2000; 15(10): 1525 - 1528. [Full Text] [PDF]
|
|
|
|
|
|
K. Goto, K. Fujii, U. Onaka, I. Abe, and M. Fujishima Renin-Angiotensin System Blockade Improves Endothelial Dysfunction in Hypertension Hypertension, October 1, 2000; 36(4): 575 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Goto, K. Fujii, U. Onaka, I. Abe, and M. Fujishima Angiotensin-Converting Enzyme Inhibitor Prevents Age-Related Endothelial Dysfunction Hypertension, October 1, 2000; 36(4): 581 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. WANG, J. IVERSEN, and S. STRANDGAARD Endothelium-Dependent Relaxation of Small Resistance Vessels Is Impaired in Patients with Autosomal Dominant Polycystic Kidney Disease J. Am. Soc. Nephrol., August 1, 2000; 11(8): 1371 - 1376. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Oike, C. Kimura, T. Koyama, M. Yoshikawa, and Y. Ito Hypotonic stress-induced dual Ca2+ responses in bovine aortic endothelial cells Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H630 - H638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Saadi, R. A. Holzknecht, C. P. Patte, and J. L. Platt Endothelial Cell Activation by Pore-Forming Structures : Pivotal Role for Interleukin-1{alpha} Circulation, April 18, 2000; 101(15): 1867 - 1873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Sibelius, U. Grandel, M. Buerke, D. Mueller, L. Kiss, H.-J. Kraemer, R. Braun-Dullaeus, W. Haberbosch, W. Seeger, and F. Grimminger Staphylococcal {alpha}-Toxin Provokes Coronary Vasoconstriction and Loss in Myocardial Contractility in Perfused Rat Hearts : Role of Thromboxane Generation Circulation, January 4, 2000; 101(1): 78 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Liu Constriction to hypoxia-reoxygenation in isolated mouse coronary arteries: role of endothelium and superoxide J Appl Physiol, October 1, 1999; 87(4): 1392 - 1396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mamluk, N. Levy, B. Rueda, J. S. Davis, and R. Meidan Characterization and Regulation of Type A Endothelin Receptor Gene Expression in Bovine Luteal Cell Types Endocrinology, May 1, 1999; 140(5): 2110 - 2116. [Abstract] [Full Text]
|
|
|
|
|
|
F. RUSCHITZKA, S. SHAW, D. GYGI, G. NOLL, M. BARTON, and T. F. LÜSCHER Endothelial Dysfunction in Acute Renal Failure: Role of Circulatingand Tissue Endothelin-1 J. Am. Soc. Nephrol., May 1, 1999; 10(5): 953 - 962. [Abstract] [Full Text]
|
|
|
|
|
|
Q. Liu and J. T. Sylvester Development of intrinsic tone in isolated pulmonary arterioles Am J Physiol Lung Cell Mol Physiol, May 1, 1999; 276(5): L805 - L813. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Korth, R. M. Bohle, P. Corvol, and F. Pinet Cellular Distribution of Endothelin-converting Enzyme-1 in Human Tissues J. Histochem. Cytochem., April 1, 1999; 47(4): 447 - 462. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. L. Rosenfeldt, G.-W. He, B. F. Buxton, and J. A. Angus Pharmacology of coronary artery bypass grafts Ann. Thorac. Surg., March 1, 1999; 67(3): 878 - 888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. DeFily, Y. Nishikawa, and W. M. Chilian Endothelin antagonists block alpha 1-adrenergic constriction of coronary arterioles Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H1028 - H1034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Onaka, K. Fujii, I. Abe, and M. Fujishima Antihypertensive Treatment Improves Endothelium-Dependent Hyperpolarization in the Mesenteric Artery of Spontaneously Hypertensive Rats Circulation, July 14, 1998; 98(2): 175 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Mathier, G. A. Rose, M. A. Fifer, M. I. Miyamoto, R. E. Dinsmore, H. H. Castano, G. W. Dec, I. F. Palacios, and M. J. Semigran Coronary endothelial dysfunction in patients with acute-onset idiopathic dilated cardiomyopathy J. Am. Coll. Cardiol., July 1, 1998; 32(1): 216 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gheorghiade and R. O. Bonow Chronic Heart Failure in the United States : A Manifestation of Coronary Artery Disease Circulation, January 27, 1998; 97(3): 282 - 289. [Full Text] [PDF]
|
|
|
|
|
|
K. M. Gauthier-Rein and N. J. Rusch Distinct Endothelial Impairment in Coronary Microvessels from Hypertensive Dahl Rats Hypertension, January 1, 1998; 31(1): 328 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Bu and T. Quertermous Identification of an Endothelial Cell-specific Regulatory Region in the Murine Endothelin-1 Gene J. Biol. Chem., December 19, 1997; 272(51): 32613 - 32622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Welch, B. Peng, K. Takeuchi, K. Abe, and C. S. Wilcox Salt loading enhances rat renal TxA2/PGH2 receptor expression and TGF response to U-46,619 Am J Physiol Renal Physiol, December 1, 1997; 273(6): F976 - F983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hasdai, V. Mathew, R. S. Schwartz, L. A. Smith, D. R. Holmes Jr, Z. S. Katusic, and A. Lerman Enhanced Endothelin-B-Receptor–Mediated Vasoconstriction of Small Porcine Coronary Arteries in Diet-Induced Hypercholesterolemia Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2737 - 2743. [Abstract] [Full Text]
|
|
|
|
|
|
F. Pourageaud and J. G. R. De Mey Structural properties of rat mesenteric small arteries after 4-wk exposure to elevated or reduced blood flow Am J Physiol Heart Circ Physiol, October 1, 1997; 273(4): H1699 - H1706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Barton, F. Cosentino, R. P. Brandes, P. Moreau, S. Shaw, and T. F. Luscher Anatomic Heterogeneity of Vascular Aging : Role of Nitric Oxide and Endothelin Hypertension, October 1, 1997; 30(4): 817 - 824. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. B. Hoover and D. A. Neely Differentiation of Muscarinic Receptors Mediating Negative Chronotropic and Vasoconstrictor Responses to Acetylcholine in Isolated Rat Hearts J. Pharmacol. Exp. Ther., September 1, 1997; 282(3): 1337 - 1344. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Houghton, V. E. Smith, D. S. Strogatz, N. L. Henches, W. M. Breisblatt, and A. A. Carr Effect of African-American Race and Hypertensive Left Ventricular Hypertrophy on Coronary Vascular Reactivity and Endothelial Function Hypertension, March 1, 1997; 29(3): 706 - 714. [Abstract] [Full Text]
|
|
|
|
|
|
T. Minamino, H. Kurihara, M. Takahashi, K. Shimada, K. Maemura, H. Oda, T. Ishikawa, T. Uchiyama, K. Tanzawa, and Y. Yazaki Endothelin-Converting Enzyme Expression in the Rat Vascular Injury Model and Human Coronary Atherosclerosis Circulation, January 7, 1997; 95(1): 221 - 230. [Abstract] [Full Text]
|
|
|
|
|
|
L. V. d'Uscio, P. Moreau, S. Shaw, H. Takase, M. Barton, and T. F. Luscher Effects of Chronic ETA-Receptor Blockade in Angiotensin II-Induced Hypertension Hypertension, January 1, 1997; 29(1): 435 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Antony, G. Lerebours, and A. Nitenberg Angiotensin-Converting Enzyme Inhibition Restores Flow-Dependent and Cold Pressor Test–Induced Dilations in Coronary Arteries of Hypertensive Patients Circulation, December 15, 1996; 94(12): 3115 - 3122. [Abstract] [Full Text]
|
|
|
|
|
|
P.M. Piatti, L.D. Monti, G. Valsecchi, M. Conti, R. Nasser, B. Guazzini, E. Fochesato, C.V. Phan, A.E. Pontiroli, and G. Pozza Effects of Low-Dose Heparin Infusion on Arterial Endothelin-1 Release in Humans Circulation, December 1, 1996; 94(11): 2703 - 2707. [Abstract] [Full Text]
|
|
|
|
|
|
E. C. Fletcher and G. Bao Effect of episodic eucapnic and hypocapnic hypoxia on systemic blood pressure in hypertension-prone rats J Appl Physiol, November 1, 1996; 81(5): 2088 - 2094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Zaugg, P. S. Hornstein, P. Zhu, D. Simper, T. F. Luscher, P. R. Allegrini, and P. T. Buser Endothelin-1–Induced Release of Thromboxane A2 Increases the Vasoconstrictor Effect of Endothelin-1 in Postischemic Reperfused Rat Hearts Circulation, August 15, 1996; 94(4): 742 - 747. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Hasdai, E. Erez, I. Gil-Ad, E. Raanani, S. Sclarovsky, Y. Barak, J. Sulkes, and B. A. Vidne IS THE HEART A SOURCE FOR ELEVATED CIRCULATING ENDOTHELIN LEVELS DURING AORTA--CORONARY ARTERY BYPASS GRAFTING SURGERY IN HUMAN BEINGS? J. Thorac. Cardiovasc. Surg., August 1, 1996; 112(2): 531 - 536. [Abstract] [Full Text]
|
|
|
|
|
|
G.B. J. Mancini, G. C. Henry, C. Macaya, B. J. O'Neill, A. L. Pucillo, R. G. Carere, T. J. Wargovich, H. Mudra, T. F. Luscher, M. I. Klibaner, et al. Angiotensin-Converting Enzyme Inhibition With Quinapril Improves Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease: The TREND (Trial on Reversing ENdothelial Dysfunction) Study Circulation, August 1, 1996; 94(3): 258 - 265. [Abstract] [Full Text]
|
|
|
|
|
|
C. F. Kung, P. Moreau, H. Takase, and T. F. Luscher L-NAME Hypertension Alters Endothelial and Smooth Muscle Function in Rat Aorta : Prevention by Trandolapril and Verapamil Hypertension, November 1, 1995; 26(5): 744 - 751. [Abstract] [Full Text]
|
|
|
|
|
|
M.R. Tschudi and T.F. Luscher Age and Hypertension Differently Affect Coronary Contractions to Endothelin-1, Serotonin, and Angiotensins Circulation, May 1, 1995; 91(9): 2415 - 2422. [Abstract] [Full Text]
|
|
|
|
|
|
B. Seo and T. F. Luscher ETA and ETB Receptors Mediate Contraction to Endothelin-1 in Renal Artery of Aging SHR : Effects of FR139317 and Bosentan Hypertension, April 1, 1995; 25(4): 501 - 506. [Abstract] [Full Text]
|
|
|
|
|
|
H. Takase, P. Moreau, and T. F. Luscher Endothelin Receptor Subtypes in Small Arteries : Studies With FR139317 and Bosentan Hypertension, April 1, 1995; 25(4): 739 - 743. [Abstract] [Full Text]
|
|
|
|
|
|
G.-W. He, C.-Q. Yang, and A. Starr Overview of the Nature of Vasoconstriction in Arterial Grafts for Coronary Operations Ann. Thorac. Surg., March 1, 1995; 59(3): 676 - 683. [Abstract] [Full Text]
|
|
|
|
|
|
V. Richard, M. Hogie, M. Clozel, B.-M. Loffler, and C. Thuillez In Vivo Evidence of an Endothelin-Induced Vasopressor Tone After Inhibition of Nitric Oxide Synthesis in Rats Circulation, February 1, 1995; 91(3): 771 - 775. [Abstract] [Full Text]
|
|
|
|
|
|
C. F. Kung and T. F. Luscher Different Mechanisms of Endothelial Dysfunction With Aging and Hypertension in Rat Aorta Hypertension, February 1, 1995; 25(2): 194 - 200. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. M. Hallenbeck and K. U. Frerichs Stroke Therapy: It May Be Time for an Integrated Approach Arch Neurol, July 1, 1993; 50(7): 768 - 770. [Abstract] [PDF]
|
|