This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Toda, N. Articles by Okamura, T. Search for Related Content PubMed PubMed Citation Articles by Toda, N. Articles by Okamura, T.

Hypertension, Vol 19, 161-166, Copyright © 1992 by American Heart Association

ARTICLES

Mechanism of neurally induced monkey mesenteric artery relaxation and contraction

N Toda and T Okamura
Department of Pharmacology, Shiga University of Medical Sciences, Ohtsu, Japan.

Physiological importance in vasodilator innervation alleviating noradrenergic neurogenic vasoconstriction has not been clarified. Isolated monkey mesenteric artery strips denuded of the endothelium responded to nerve stimulation by electrical pulses or nicotine with a contraction, which was potentiated by Ng-nitro-L-arginine, a nitric oxide synthesis inhibitor, but not by the D-enantiomer. The potentiation was abolished by L-arginine. NG-Nitro-L-arginine did not potentiate the response to exogenous norepinephrine nor did it increase the release of [3H]norepinephrine from adrenergic nerves electrically stimulated. The contraction was reversed by treatment with phentolamine and guanethidine to a relaxation, which was abolished by NG-nitro-L- arginine. The inhibition was reversed by L- but not D-arginine. The relaxant response was not influenced by atropine, timolol, or indomethacin. These findings strongly suggest the importance of reciprocal nitric oxide-related (nitroxidergic) vasodilator and noradrenergic vasoconstrictor innervation in the regulation of monkey arterial tone.

This article has been cited by other articles:

				Y. Hatanaka, N. Hobara, J. Honghua, S. Akiyama, H. Nawa, Y. Kobayashi, F. Takayama, Y. Gomita, and H. Kawasaki Neuronal Nitric-Oxide Synthase Inhibition Facilitates Adrenergic Neurotransmission in Rat Mesenteric Resistance Arteries J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 490 - 497. [Abstract] [Full Text] [PDF]

				M. Esler and N. Eikelis Is obstructive sleep apnea the cause of sympathetic nervous activation in human obesity? J Appl Physiol, January 1, 2006; 100(1): 11 - 12. [Full Text] [PDF]

				N. Toda and T. Okamura The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels Pharmacol. Rev., June 1, 2003; 55(2): 271 - 324. [Abstract] [Full Text] [PDF]

				P. Palatini, O. Vriz, S. Nesbitt, J. Amerena, S. Majahalme, M. Valentini, and S. Julius Parental Hyperdynamic Circulation Predicts Insulin Resistance in Offspring : The Tecumseh Offspring Study Hypertension, March 1, 1999; 33(3): 769 - 774. [Abstract] [Full Text] [PDF]

				T. Okamura, K. Ayajiki, and N. Toda Monkey corpus cavernosum relaxation mediated by NO and other relaxing factor derived from nerves Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1075 - H1081. [Abstract] [Full Text] [PDF]

				H. Kawasaki, M. Takenaga, H. Araki, K. Futagami, and Y. Gomita Angiotensin Inhibits Neurotransmission of Calcitonin Gene-Related Peptide-Containing Vasodilator Nerves in Mesenteric Artery of Spontaneously Hypertensive Rats J. Pharmacol. Exp. Ther., February 1, 1998; 284(2): 508 - 515. [Abstract] [Full Text]

				E. B. Coelho, G. Ballejo, and M. C. O. Salgado Nitric Oxide Blunts Sympathetic Response of Pregnant Normotensive and Hypertensive Rat Arteries Hypertension, September 1, 1997; 30(3): 585 - 588. [Abstract] [Full Text]

				S. Cellek and S. Moncada Nitrergic control of peripheral sympathetic responses in the human corpus cavernosum: A comparison with other species PNAS, July 22, 1997; 94(15): 8226 - 8231. [Abstract] [Full Text] [PDF]

				G. Matsuo, Y. Matsumura, K. Tadano, and S. Morimoto Effects of Sarafotoxin S6c on Antidiuresis and Norepinephrine Overflow Induced by Stimulation of Renal Nerves in Anesthetized Dogs J. Pharmacol. Exp. Ther., February 1, 1997; 280(2): 905 - 910. [Abstract] [Full Text]

				T. Okamura, K. Ayajiki, and N. Toda Neural Mechanism of Pressor Action of Nitric Oxide Synthase Inhibitor in Anesthetized Monkeys Hypertension, September 1, 1996; 28(3): 341 - 346. [Abstract] [Full Text]

				T. Okamura, K. Yoshida, and N. Toda Nitroxidergic Innervation in Dog and Monkey Renal Arteries Hypertension, May 1, 1995; 25(5): 1090 - 1095. [Abstract] [Full Text]