Hypertension, Vol 19, 270-277, Copyright © 1992 by American Heart Association
W Wang, JM McClain and IH Zucker
We have previously demonstrated that baroreceptor discharge sensitivity is
depressed in dogs with experimental heart failure and that this depressed
sensitivity can be reversed by the Na+,K(+)-ATPase inhibitor ouabain. This
suggests that enhanced Na+,K(+)-ATPase activity in baroreceptors is
responsible for the blunted baroreceptor discharge sensitivity seen in
heart failure state. Because aldosterone, a known stimulator of
Na+,K(+)-ATPase, is elevated in heart failure the present study was
undertaken to determine the effects on baroreceptor discharge of perfusion
of the carotid sinus with aldosterone in normotensive dogs. Single unit
baroreceptor activity was recorded as well as carotid sinus pressure and
the diameter of the carotid sinus. Perfusion of the carotid sinus with
aldosterone (in Krebs-Henseleit solution) significantly elevated threshold
pressure (108.5 +/- 3.1 mm Hg versus 92.7 +/- 4.6 mm Hg, p less than 0.05)
and reduced peak discharge rate (40.3 +/- 3.9 spikes/sec, p less than
0.05). These effects appeared 15 minutes after aldosterone perfusion and
remained constant for the next 60 minutes. There was no change in the
carotid sinus pressure-diameter curve during perfusion with aldosterone.
Perfusion of the carotid sinus with ouabain (0.1 microgram/ml) during
aldosterone perfusion did not reverse the blunted baroreceptor discharge.
The blunted baroreceptor activity induced by perfusion of the carotid sinus
with aldosterone was prevented by removal of the endothelial cells in the
carotid sinus area with a balloon-tipped catheter or by perfusion with
saponin. Finally, perfusion of the carotid sinus with spironolactone (10
ng/ml), a mineralocorticoid receptor antagonist, prevented the inhibitory
effect of aldosterone. These data suggest that aldosterone reduces maximum
baroreceptor discharge.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Aldosterone reduces baroreceptor discharge in the dog
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha 68198-4575.
This article has been cited by other articles:
 |
|
 |
|
  B. P. Shapiro, T. E. Owan, S. Mohammed, M. Kruger, W. A. Linke, J. C. Burnett Jr, and M. M. Redfield Mineralocorticoid Signaling in Transition to Heart Failure With Normal Ejection Fraction Hypertension, February 1, 2008; 51(2): 289 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Bobadilla and G. Gamba New insights into the pathophysiology of cyclosporine nephrotoxicity: a role of aldosterone Am J Physiol Renal Physiol, July 1, 2007; 293(1): F2 - F9. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Monahan, U. A. Leuenberger, and C. A. Ray Aldosterone impairs baroreflex sensitivity in healthy adults Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H190 - H197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C Shah, S. Pringle, and A. Struthers Aldosterone Blockade Over and Above ACE-Inhibitors in Patients with Coronary Artery Disease but without Heart Failure Journal of Renin-Angiotensin-Aldosterone System, March 1, 2006; 7(1): 20 - 30. [Abstract] [PDF]
|
|
|
|
 |
|
 J. C. Aldigier, T. Kanjanbuch, L.-J. Ma, N. J. Brown, and A. B. Fogo Regression of Existing Glomerulosclerosis by Inhibition of Aldosterone J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3306 - 3314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Perez-Rojas, S. Derive, J. A. Blanco, C. Cruz, L. M. de la Maza, G. Gamba, and N. A. Bobadilla Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1020 - F1030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M C Connell and E. Davies The new biology of aldosterone J. Endocrinol., July 1, 2005; 186(1): 1 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Rad, R. J. Balment, and N. Ashton Rapid natriuretic action of aldosterone in the rat J Appl Physiol, February 1, 2005; 98(2): 423 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M P Frenneaux Autonomic changes in patients with heart failure and in post-myocardial infarction patients Heart, November 1, 2004; 90(11): 1248 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Struthers The clinical implications of aldosterone escape in congestive heart failure Eur J Heart Fail, August 1, 2004; 6(5): 539 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fletcher, A. N. Buch, H. C. Routledge, S. Chowdhary, J. H. Coote, and J. N. Townend Acute aldosterone antagonism improves cardiac vagal control in humans J. Am. Coll. Cardiol., April 7, 2004; 43(7): 1270 - 1275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D Struthers Aldosterone blockade in heart failure Journal of Renin-Angiotensin-Aldosterone System, March 1, 2004; 5(1_suppl): S23 - S27. [Abstract] [PDF]
|
|
|
|
 |
|
 R. M. LOSEL, E. FALKENSTEIN, M. FEURING, A. SCHULTZ, H.-C. TILLMANN, K. ROSSOL-HASEROTH, and M. WEHLING Nongenomic Steroid Action: Controversies, Questions, and Answers Physiol Rev, July 1, 2003; 83(3): 965 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Felder, J. Francis, Z.-H. Zhang, S.-G. Wei, R. M. Weiss, and A. K. Johnson Heart failure and the brain: new perspectives Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R259 - R276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gunaruwan, M. Schmitt, J. Taylor, L. Lee, A. Struthers, and M. Frenneaux Lack of rapid aldosterone effects on forearm resistance vasculature in health Journal of Renin-Angiotensin-Aldosterone System, June 1, 2002; 3(2): 123 - 125. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Ngarmukos and R. J. Grekin Nontraditional aspects of aldosterone physiology Am J Physiol Endocrinol Metab, December 1, 2001; 281(6): E1122 - E1127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Francis, R. M. Weiss, S.-G. Wei, A. K. Johnson, T. G. Beltz, K. Zimmerman, and R. B. Felder Central mineralocorticoid receptor blockade improves volume regulation and reduces sympathetic drive in heart failure Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2241 - H2251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-M. Yee, S. D. Pringle, and A. D. Struthers Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1800 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Falkenstein, A. W. Norman, and M. Wehling Mannheim Classification of Nongenomically Initiated (Rapid) Steroid Action(s) J. Clin. Endocrinol. Metab., May 1, 2000; 85(5): 2072 - 2075. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Christ, A. Gunther, M. Heck, B. M. W. Schmidt, E. Falkenstein, and M. Wehling Aldosterone, Not Estradiol, Is the Physiological Agonist for Rapid Increases in cAMP in Vascular Smooth Muscle Cells Circulation, March 23, 1999; 99(11): 1485 - 1491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ma, I. H. Zucker, and W. Wang Reduced NO enhances the central gain of cardiac sympathetic afferent reflex in dogs with heart failure Am J Physiol Heart Circ Physiol, January 1, 1999; 276(1): H19 - H26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Christ and M. Wehling Cardiovascular steroid actions: swift swallows or sluggish snails? Cardiovasc Res, October 1, 1998; 40(1): 34 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Atherton, H. L. Thomson, T. D. Moore, K. N. Wright, G. W. F. Muehle, L. E. Fitzpatrick, and M. P. Frenneaux Diastolic Ventricular Interaction : A Possible Mechanism for Abnormal Vascular Responses During Volume Unloading in Heart Failure Circulation, December 16, 1997; 96(12): 4273 - 4279. [Abstract] [Full Text]
|
|
|
|
|
|
B. S. Huang, B. Yuan, and F. H. H. Leenen Blockade of Brain `Ouabain' Prevents the Impairment of Baroreflexes in Rats After Myocardial Infarction Circulation, September 2, 1997; 96(5): 1654 - 1659. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. D. Sackner-Bernstein and D. M. Mancini Rationale for Treatment of Patients With Chronic Heart Failure With Adrenergic Blockade JAMA, November 8, 1995; 274(18): 1462 - 1467. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Wehling, C. B. Neylon, M. Fullerton, A. Bobik, and J. W. Funder Nongenomic Effects of Aldosterone on Intracellular Ca2+ in Vascular Smooth Muscle Cells Circ. Res., June 1, 1995; 76(6): 973 - 979. [Abstract] [Full Text]
|
|