Hypertension, Vol 19, 314-319, Copyright © 1992 by American Heart Association
K Yasunari, M Kohno, K Murakawa, K Yokokawa, T Horio and T Takeda
At least two types of receptors for natriuretic peptides have been
reported: biologically active receptors coupled with guanylate cyclase
(atrial natriuretic peptide [ANP]-B receptors) and clearance receptors
(ANP-C receptors). To elucidate the role of protein kinase C (PKC) in the
regulation of ANP-B receptors, vascular smooth muscle cells in culture were
treated with phorbol ester. Incubation with receptor agonists and phorbol
ester led to the desensitization of receptor- mediated cyclic guanosine
monophosphate (ANP-B receptor response) in rat vascular smooth muscle
cells. Although a PKC inhibitor and downregulation of PKC by long-term
incubation of cells with phorbol esters blocked the phorbol ester-induced
desensitization of the ANP-B receptor response, they did not block the
ANP-induced desensitization of the ANP-B receptor response. In addition,
when desensitization by phorbol esters was observed, ANP was still capable
of desensitization. These observations suggest that the mechanism for
regulating ANP-B receptor sensitivity may be both PKC-dependent and
PKC-independent and mediated by phorbol esters and ANP, respectively.
ARTICLES
Phorbol ester and atrial natriuretic peptide receptor response on vascular smooth muscle
First Department of Internal Medicine, Osaka City University Medical School, Japan.
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