Hypertension, Vol 19, 339-344, Copyright © 1992 by American Heart Association
RC Frederich Jr, BB Kahn, MJ Peach and JS Flier
Recent studies have found that angiotensinogen is expressed in white and
brown fat pads, and adipocytes have been implicated as a primary source of
angiotensinogen in several other tissues. The functional significance of
this unexpected expression is unknown. To address this, we studied
angiotensinogen messenger RNA (mRNA) expression and angiotensinogen
secretion in adipose tissue and isolated adipocytes comparing fasted and
refed rodents and those with genetic obesity with normal controls. Control
2-month-old Sprague-Dawley rats, those fasted for 3 days, or those fasted
for 2 days and refed for 6 days were killed, and adipocytes were isolated
from epididymal fat pads using collagenase digestion. Angiotensinogen mRNA
was reduced to 14.6 +/- 2.3% of control levels under fasted conditions and
increased to 228 +/- 53% of control levels after refeeding. Angiotensinogen
release from adipocytes was reduced to 33% of control levels by fasting and
increased to 183% by refeeding. These effects of fasting and refeeding on
angiotensinogen regulation were tissue specific since liver angiotensinogen
mRNA and serum angiotensinogen concentrations were unaffected. Systolic
blood pressure, however, was modulated by fasting and refeeding in a manner
parallel to adipocyte angiotensinogen expression. In related experiments,
angiotensinogen secretion per epididymal fat pad of the ob/ob mouse model
of obesity was increased an average of 3.4-fold compared with control. We
conclude angiotensinogen expression in white adipocytes is regulated
nutritionally in a tissue- specific manner. We propose that adipocyte
angiotensinogen could play a previously unrecognized role in regulating
adipose tissue blood supply and thereby fatty acid efflux from
fat.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Tissue-specific nutritional regulation of angiotensinogen in adipose tissue
Department of Medicine, Beth Israel Hospital, Boston, MA 02215.
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