Hypertension, Vol 19, 456-463, Copyright © 1992 by American Heart Association
YF Chen, AJ Naftilan and S Oparil
Our previous studies demonstrated that the sexually dimorphic pattern of
hypertension in the spontaneously hypertensive rat is androgen dependent.
Gonadectomy retards the development of hypertension in young males, but not
in females, and administration of testosterone propionate to gonadectomized
spontaneously hypertensive rats of both sexes confers a male pattern of
blood pressure development. The current study tested the hypothesis that
renal and hepatic renin and angiotensinogen gene expression are also
androgen dependent in the spontaneously hypertensive rat. Male and female
spontaneously hypertensive rats underwent gonadectomy or a sham operation
at 4 weeks of age. Subgroups of gonadectomized rats of both sexes were
implanted with a 15-mm or 30-mm Silastic capsule filled with testosterone
at the same time the gonadectomy was performed; a third group received an
empty Silastic capsule. Northern and slot blot analyses were used to
characterize and quantitate renin and angiotensinogen messenger RNA (mRNA)
in the kidney and liver 18 weeks after the gonadectomy. Blood pressure,
plasma renin activity, and hepatic angiotensinogen mRNA levels were higher
in intact males than in females. Orchidectomy retarded the development of
hypertension and lowered plasma renin and renal and hepatic angiotensinogen
mRNA levels, and testosterone replacement restored the male pattern of
hypertension and plasma renin and increased renal and hepatic
angiotensinogen mRNA. Ovariectomy did not alter blood pressure or plasma
renin but did lower renal renin and renal and hepatic angiotensinogen mRNA;
testosterone increased blood pressure, plasma renin, renal renin and
angiotensinogen mRNA, and hepatic angiotensinogen mRNA levels in
ovariectomized females.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Androgen-dependent angiotensinogen and renin messenger RNA expression in hypertensive rats
Department of Medicine, University of Alabama, Birmingham 35294.
This article has been cited by other articles:
 |
|
 |
|
  M. Yaron, Y. Greenman, J. B Rosenfeld, E. Izkhakov, R. Limor, E. Osher, G. Shenkerman, K. Tordjman, and N. Stern Effect of testosterone replacement therapy on arterial stiffness in older hypogonadal men Eur. J. Endocrinol., May 1, 2009; 160(5): 839 - 846. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Yanes, J. C. Sartori-Valinotti, R. Iliescu, D. G. Romero, L. C. Racusen, H. Zhang, and J. F. Reckelhoff Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats Am J Physiol Renal Physiol, April 1, 2009; 296(4): F771 - F779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Anton and K. B. Brosnihan Review: Systemic and uteroplacental renin--angiotensin system in normal and pre-eclamptic pregnancies Therapeutic Advances in Cardiovascular Disease, October 1, 2008; 2(5): 349 - 362. [Abstract] [PDF]
|
|
|
|
 |
|
 N. B. Ojeda, D. Grigore, and B. T. Alexander Developmental Programming of Hypertension: Insight From Animal Models of Nutritional Manipulation Hypertension, July 1, 2008; 52(1): 44 - 50. [Full Text] [PDF]
|
|
|
|
|
|
L. L. Yanes, J. C. Sartori-Valinotti, and J. F. Reckelhoff Sex Steroids and Renal Disease: Lessons From Animal Studies Hypertension, April 1, 2008; 51(4): 976 - 981. [Full Text] [PDF]
|
|
|
|
|
|
L. Anton, D. C. Merrill, L. A.A. Neves, K. Stovall, P. E. Gallagher, D. I. Diz, C. Moorefield, C. Gruver, C. M. Ferrario, and K. B. Brosnihan Activation of Local Chorionic Villi Angiotensin II Levels But Not Angiotensin (1-7) in Preeclampsia Hypertension, April 1, 2008; 51(4): 1066 - 1072. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Sullivan, L. Semprun-Prieto, E. I. Boesen, D. M. Pollock, and J. S. Pollock Sex and sex hormones influence the development of albuminuria and renal macrophage infiltration in spontaneously hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1573 - R1579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Chen, W.-S. Yang, J.-H. Yang, C.-L. Chen, H.-N. Ho, and Y.-S. Yang Relationship Between Androgen Levels and Blood Pressure in Young Women With Polycystic Ovary Syndrome Hypertension, June 1, 2007; 49(6): 1442 - 1447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Iliescu, V. E. Cucchiarelli, L. L. Yanes, J. W. Iles, and J. F. Reckelhoff Impact of androgen-induced oxidative stress on hypertension in male SHR Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R731 - R735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. B. Ojeda, D. Grigore, L. L. Yanes, R. Iliescu, E. B. Robertson, H. Zhang, and B. T. Alexander Testosterone contributes to marked elevations in mean arterial pressure in adult male intrauterine growth restricted offspring Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R758 - R763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Vargas, J. M. Moreno, R. Wangensteen, I. Rodriguez-Gomez, and J. Garcia-Estan The endocrine system in chronic nitric oxide deficiency Eur. J. Endocrinol., January 1, 2007; 156(1): 1 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Yanes, D. G. Romero, J. W. Iles, R. Iliescu, C. Gomez-Sanchez, and J. F. Reckelhoff Sexual dimorphism in the renin-angiotensin system in aging spontaneously hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R383 - R390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Song, C. K. Kost Jr., and D. S. Martin Androgens augment renal vascular responses to ANG II in New Zealand genetically hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1608 - R1615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Reckelhoff, L. L. Yanes, R. Iliescu, L. A. Fortepiani, and J. P. Granger Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease Am J Physiol Renal Physiol, November 1, 2005; 289(5): F941 - F948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Vasudevan, H. Xiang, and J. H. McNeill Differential regulation of insulin resistance and hypertension by sex hormones in fructose-fed male rats Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1335 - H1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Reckelhoff Sex Steroids, Cardiovascular Disease, and Hypertension: Unanswered Questions and Some Speculations Hypertension, February 1, 2005; 45(2): 170 - 174. [Full Text] [PDF]
|
|
|
|
|
|
A. Quan, S. Chakravarty, J.-K. Chen, J.-C. Chen, S. Loleh, N. Saini, R. C. Harris, J. Capdevila, and R. Quigley Androgens augment proximal tubule transport Am J Physiol Renal Physiol, September 1, 2004; 287(3): F452 - F459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Reckelhoff and L. A. Fortepiani Novel Mechanisms Responsible for Postmenopausal Hypertension Hypertension, May 1, 2004; 43(5): 918 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sainz, A. Osuna, R. Wangensteen, J. de Dios Luna, I. Rodriguez-Gomez, J. Duarte, J. M. Moreno, and F. Vargas Role of sex, gonadectomy and sex hormones in the development of nitric oxide inhibition-induced hypertension Exp Physiol, March 1, 2004; 89(2): 155 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-L. Gross, M. Adamczak, T. Rabe, N. A. Harbi, J. Krtil, A. Koch, P. Hamar, K. Amann, and E. Ritz Beneficial Effects of Estrogens on Indices of Renal Damage in Uninephrectomized SHRsp Rats J. Am. Soc. Nephrol., February 1, 2004; 15(2): 348 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Li, I. Kishimoto, Y. Saito, M. Harada, K. Kuwahara, T. Izumi, I. Hamanaka, N. Takahashi, R. Kawakami, K. Tanimoto, et al. Androgen Contributes to Gender-Related Cardiac Hypertrophy and Fibrosis in Mice Lacking the Gene Encoding Guanylyl Cyclase-A Endocrinology, February 1, 2004; 145(2): 951 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Fortepiani, L. Yanes, H. Zhang, L. C. Racusen, and J. F. Reckelhoff Role of Androgens in Mediating Renal Injury in Aging SHR Hypertension, November 1, 2003; 42(5): 952 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Fortepiani, H. Zhang, L. Racusen, L. J. Roberts II, and J. F. Reckelhoff Characterization of an Animal Model of Postmenopausal Hypertension in Spontaneously Hypertensive Rats Hypertension, March 1, 2003; 41(3): 640 - 645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Baltatu, C. Cayla, R. Iliescu, D. Andreev, and M. Bader Abolition of End-Organ Damage by Antiandrogen Treatment in Female Hypertensive Transgenic Rats Hypertension, March 1, 2003; 41(3): 830 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Baltatu, C. Cayla, R. Iliescu, D. Andreev, C. Jordan, and M. Bader Abolition of Hypertension-Induced End-Organ Damage by Androgen Receptor Blockade in Transgenic Rats Harboring the Mouse Ren-2 Gene J. Am. Soc. Nephrol., November 1, 2002; 13(11): 2681 - 2687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fischer, A. Baessler, and H. Schunkert Renin angiotensin system and gender differences in the cardiovascular system Cardiovasc Res, February 15, 2002; 53(3): 672 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Dubey, S. Oparil, B. Imthurn, and E. K. Jackson Sex hormones and hypertension Cardiovasc Res, February 15, 2002; 53(3): 688 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A Babiker, L. J De Windt, M. van Eickels, C. Grohe, R. Meyer, and P. A Doevendans Estrogenic hormone action in the heart: regulatory network and function Cardiovasc Res, February 15, 2002; 53(3): 709 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Khalid, N. Ilhami, Y. Giudicelli, and J.-P. Dausse Testosterone Dependence of Salt-Induced Hypertension in Sabra Rats and Role of Renal alpha 2-Adrenoceptor Subtypes J. Pharmacol. Exp. Ther., January 1, 2002; 300(1): 43 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Reckelhoff Gender Differences in the Regulation of Blood Pressure Hypertension, May 1, 2001; 37(5): 1199 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Serazin-Leroy, M. Morot, P. de Mazancourt, and Y. Giudicelli Androgen regulation and site specificity of angiotensinogen gene expression and secretion in rat adipocytes Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1398 - E1405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. G. Verhagen, D. M. A. Attia, H. A. Koomans, and J. A. Joles Male gender increases sensitivity to proteinuria induced by mild NOS inhibition in rats: role of sex hormones Am J Physiol Renal Physiol, October 1, 2000; 279(4): F664 - F670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Reckelhoff, H. Zhang, and K. Srivastava Gender Differences in Development of Hypertension in Spontaneously Hypertensive Rats : Role of the Renin-Angiotensin System Hypertension, January 1, 2000; 35(1): 480 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L Kuroski de Bold Estrogen, natriuretic peptides and the renin-angiotensin system Cardiovasc Res, March 1, 1999; 41(3): 524 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Gallagher, P. Li, J. R. Lenhart, M. C. Chappell, and K. B. Brosnihan Estrogen Regulation of Angiotensin-Converting Enzyme mRNA Hypertension, January 1, 1999; 33(1): 323 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Sharkey, B. J. Holycross, S. Park, S. A. McCune, R. Hoversland, and M. J. Radin Effect of ovariectomy in heart failure-prone SHHF/Mcc-facp rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1998; 275(6): R1968 - R1976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Jones, G. Dunphy, A. Milsted, and D. Ely Testosterone Effects on Renal Norepinephrine Content and Release in Rats With Different Y Chromosomes Hypertension, November 1, 1998; 32(5): 880 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M J. Melia, N. Bofill, M. Hubank, and A. Meseguer Identification of Androgen-Regulated Genes in Mouse Kidney by Representational Difference Analysis and Random Arbitrarily Primed Polymerase Chain Reaction Endocrinology, February 1, 1998; 139(2): 688 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Reckelhoff, H. Zhang, and J. P. Granger Testosterone Exacerbates Hypertension and Reduces Pressure-Natriuresis in Male Spontaneously Hypertensive Rats Hypertension, January 1, 1998; 31(1): 435 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Brosnihan, P. Li, D. Ganten, and C. M. Ferrario Estrogen protects transgenic hypertensive rats by shifting the vasoconstrictor-vasodilator balance of RAS Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1997; 273(6): R1908 - R1915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Reckelhoff, H. Zhang, and J. P. Granger Decline in Renal Hemodynamic Function in Aging SHR : Role of Androgens Hypertension, September 1, 1997; 30(3): 677 - 681. [Abstract] [Full Text]
|
|
|
|
|
|
N. D. L. Fisher, C. Ferri, C. Bellini, A. Santucci, R. Gleason, G. H. Williams, N. K. Hollenberg, and E. W. Seely Age, Gender, and Non-modulation : A Sexual Dimorphism in Essential Hypertension Hypertension, April 1, 1997; 29(4): 980 - 985. [Abstract] [Full Text]
|
|
|
|
|
|
J. Alfie, G. D. Waisman, C. R. Galarza, M. I. Magi, F. Vasvari, L. M. Mayorga, and M. I. Camera Relationship Between Systemic Hemodynamics and Ambulatory Blood Pressure Level Are Sex Dependent Hypertension, December 1, 1995; 26(6): 1195 - 1199. [Abstract] [Full Text]
|
|
|
|
|
|
T. Kumai, M. Tanaka, M. Watanabe, H. Nakura, and S. Kobayashi Influence of Androgen on Tyrosine Hydroxylase mRNA in Adrenal Medulla of Spontaneously Hypertensive Rats Hypertension, July 1, 1995; 26(1): 208 - 212. [Abstract] [Full Text]
|
|