This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jern, S. Articles by Hansson, L. Search for Related Content PubMed PubMed Citation Articles by Jern, S. Articles by Hansson, L. Pubmed/NCBI databases Medline Plus Health Information Obesity

Hypertension, Vol 19, 520-527, Copyright © 1992 by American Heart Association

ARTICLES

Relation of central hemodynamics to obesity and body fat distribution

S Jern, A Bergbrant, P Bjorntorp and L Hansson
Department of Clinical Physiology, Ostra Hospital, Goteborg, Sweden.

Central obesity increases the risk for cardiovascular disease, but little is known about its hemodynamic effects. The aims were to investigate the influence of obesity (as defined by body mass index) and abdominal fat accumulation (as defined by the waist/hip ratio) on hemodynamics at rest and during mental stress. Invasive hemodynamic studies were performed in 20 healthy, normotensive young men (aged 18- 22 years) recruited from an unbiased population sample. Their body mass index and waist/hip ratio ranged between 18.5 and 30.2 (mean 24.1) and 0.77 and 0.98 (mean 0.87), respectively. Hemodynamics were related to the two anthropometric indexes by bivariate regression analyses. Cardiac output and stroke volume were positively correlated to body mass index (p = 0.05 and p = 0.005), but inversely to waist/hip ratio (p = 0.01 and p = 0.01). Mental stress augmented the hemodynamic patterns. Total peripheral resistance during stress correlated inversely to body mass index (p = 0.02), whereas high waist/hip ratio was associated with higher systemic vascular resistance p = 0.002). The delta CO/delta MAP ratio, i.e., relative contribution of cardiac output for the stress-induced increase in mean arterial pressure, showed a strong positive association with body mass index (p = 0.004), but was inversely related to the waist/hip ratio (p = 0.002). Serum insulin correlated significantly to the stress-induced change in total peripheral resistance (r = 0.54; p = 0.02), whereas the increase in cardiac output was inversely related to insulin (r = -0.59; p = 0.007). Thus, central obesity is associated with a specific hemodynamic pattern characterized by higher total peripheral resistance, lower cardiac output, and a vasoconstrictor response to psychosocial stress.

This article has been cited by other articles:

				Z. Bagi Mechanisms of coronary microvascular adaptation to obesity Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2009; 297(3): R556 - R567. [Abstract] [Full Text] [PDF]

				D. Carroll, A. C. Phillips, and G. Der Body Mass Index, Abdominal Adiposity, Obesity, and Cardiovascular Reactions to Psychological Stress in a Large Community Sample Psychosom Med, July 1, 2008; 70(6): 653 - 660. [Abstract] [Full Text] [PDF]

				M. T. Sturman, C. F. M. de Leon, J. L. Bienias, M. C. Morris, R. S. Wilson, and D. A. Evans Body mass index and cognitive decline in a biracial community population Neurology, January 29, 2008; 70(5): 360 - 367. [Abstract] [Full Text] [PDF]

				G. D'Angelo, J. D. Mintz, J. E. Tidwell, A. M. Schreihofer, D. M. Pollock, and D. W. Stepp Exaggerated Cardiovascular Stress Responses and Impaired {beta}-Adrenergic-Mediated Pressor Recovery in Obese Zucker Rats Hypertension, December 1, 2006; 48(6): 1109 - 1115. [Abstract] [Full Text] [PDF]

				S. Malhotra, J. Poole, H. Davis, Y. Dong, J. Pollock, H. Snieder, and F. Treiber Effects of NOS3 Glu298Asp Polymorphism on Hemodynamic Reactivity to Stress: Influences of Ethnicity and Obesity Hypertension, December 1, 2004; 44(6): 866 - 871. [Abstract] [Full Text] [PDF]

				R. A. Dart, J. R. Gregoire, D. D. Gutterman, and S. H. Woolf The Association of Hypertension and Secondary Cardiovascular Disease With Sleep-Disordered Breathing Chest, January 1, 2003; 123(1): 244 - 260. [Abstract] [Full Text] [PDF]

				R. Z. Goldstein, B. E. Hurwitz, M. M. Llabre, N. Schneiderman, M. Gutt, J. S. Skyler, R. J. Prineas, and R. P. Donahue Modeling Preclinical Cardiovascular Risk for Use in Epidemiologic Studies: Miami Community Health Study Am. J. Epidemiol., October 15, 2001; 154(8): 765 - 776. [Abstract] [Full Text] [PDF]

				B. H. Saggi, H. J. Sugerman, R. R. Ivatury, and G. L. Bloomfield Analytic Reviews : Acute Abdominal Compartment Syndrome in the Critically Ill: Saggi BH, Sugerman HJ, Ivatury RR, Bloomfield GL Acute abdominal compartment syndrome in the critically ill J Intensive Care Med 1999, 14,207-219 J Intensive Care Med, September 1, 1999; 14(5): 207 - 219. [PDF]