Hypertension, Vol 19, 555-561, Copyright © 1992 by American Heart Association
EC Fletcher, J Lesske, W Qian, CC Miller 3d and T Unger
An association between chronic high blood pressure and obstructive sleep
apnea has been described. We hypothesized that repetitive episodic hypoxia
patterned after the hypoxia seen in sleep apnea could contribute to diurnal
elevation of blood pressure. Using 12-second infusions of nitrogen into
daytime sleeping chambers, four groups of male rats (250-375 g) were
subjected to intermittent hypoxia (3-5% nadir ambient oxygen) every 30
seconds, 7 hours per day for up to 35 days. In one group, blood pressure
was measured weekly by the tail-cuff method in conscious animals during 5
weeks of episodic hypoxia. In the other three groups, blood pressure was
measured in conscious animals via femoral artery catheters at baseline and
after 20, 30, or 35 days of exposure. Additional groups served as controls:
two sham groups housed in identical "hypoxia" chambers received compressed
air instead of nitrogen (35 days) while two other groups remained unhandled
in their usual cages (35 days). Both groups challenged with 35 days
episodic hypoxia showed significant increases in blood pressure compared
with controls: the tail-cuff rats showed a 21 mm Hg increase in systolic
pressure (p less than 0.05) and the intra-arterially measured rats a 13.7
mm Hg increase in mean arterial pressure (p less than 0.05). The 30-day
exposed rats also showed a 5.7 mm Hg increase in mean pressure over
baseline (p less than 0.05). Blood pressure did not change significantly
from baseline in the control groups. Left ventricle-to-body weight ratio
was higher in both 35-day exposed groups than in unhandled or sham
controls.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats
Institute for High Blood Pressure Research, Ruprecht-Karls University Heidelberg, FRG.
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Y. Arabi, B. J. Morgan, B. Goodman, D. S. Puleo, A. Xie, and J. B. Skatrud Daytime blood pressure elevation after nocturnal hypoxia J Appl Physiol, August 1, 1999; 87(2): 689 - 698. [Abstract] [Full Text] [PDF]
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E. C. Fletcher, G. Bao, and R. Li Renin Activity and Blood Pressure in Response to Chronic Episodic Hypoxia Hypertension, August 1, 1999; 34(2): 309 - 314. [Abstract] [Full Text] [PDF]
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H. E. Greenberg, A. Sica, D. Batson, and S. M. Scharf Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia J Appl Physiol, January 1, 1999; 86(1): 298 - 305. [Abstract] [Full Text] [PDF]
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E. Russi Diving and the risk of barotrauma Thorax, August 1, 1998; 53(90002): S20 - 24. [Abstract] [PDF]
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P. Grenier and C Beigelman Spiral computed tomographic scanning and magnetic resonance angiography for the diagnosis of pulmonary embolism Thorax, August 1, 1998; 53(90002): S25 - 31. [Abstract] [PDF]
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G. Bao, N. Metreveli, R. Li, A. Taylor, and E. C. Fletcher Blood pressure response to chronic episodic hypoxia: role of the sympathetic nervous system J Appl Physiol, July 1, 1997; 83(1): 95 - 101. [Abstract] [Full Text] [PDF]
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G. Bao, P. M. Randhawa, and E. C. Fletcher Acute blood pressure elevation during repetitive hypocapnic and eucapnic hypoxia in rats J Appl Physiol, April 1, 1997; 82(4): 1071 - 1078. [Abstract] [Full Text] [PDF]
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E. C. Fletcher and G. Bao Effect of episodic eucapnic and hypocapnic hypoxia on systemic blood pressure in hypertension-prone rats J Appl Physiol, November 1, 1996; 81(5): 2088 - 2094. [Abstract] [Full Text] [PDF]
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