This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Leite, R. Articles by Salgado, M. C. Search for Related Content PubMed PubMed Citation Articles by Leite, R. Articles by Salgado, M. C.

Hypertension, Vol 19, 575-581, Copyright © 1992 by American Heart Association

ARTICLES

Increased vascular formation of angiotensin II in one-kidney, one clip hypertension

R Leite and MC Salgado
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil.

To assess the role of the vascular angiotensin II-generating system in one-kidney, one clip hypertension, we determined the angiotensin converting enzyme activity in plasma and vascular tissues and examined the pressor response to angiotensin II, angiotensin I, and tetradecapeptide renin substrate in isolated mesenteric arteries from one-kidney, one clip hypertensive rats 7 and 30 days after clipping the renal artery and in mesenteric arteries from age-matched normotensive rats. Angiotensin converting enzyme activity, determined in aortic and mesenteric tissues, was significantly augmented in the hypertensive (30 days after clipping) group, whereas plasma activity was normal. The vasoconstrictor responses elicited by angiotensin I and tetradecapeptide in arteries from hypertensive rats were found to be significantly potentiated 30 days after clipping, whereas the angiotensin II responses were basically unchanged. Saralasin completely blocked the vasoconstrictor responses, whereas captopril blocked only the responses to angiotensin I without affecting the responses elicited by angiotensin II and tetradecapeptide. Enalapril, an angiotensin converting enzyme inhibitor given intravenously to unanesthetized rats, significantly lowered the blood pressure of hypertensive rats. The pressor responses elicited by angiotensin II, angiotensin I, and tetradecapeptide were completely inhibited by saralasin, whereas enalapril blocked only the responses of angiotensin I but not those elicited by angiotensin II and tetradecapeptide. These results indicate that local formation of angiotensin II is increased in arteries of one- kidney, one clip hypertensive rats. The data obtained with tetradecapeptide renin substrate suggest an important role for nonrenin proteases in vascular angiotensin II formation.

This article has been cited by other articles:

				D. O. Sivieri Jr, L. B. Bispo-da-Silva, E. B. Oliveira, A. C. Resende, and M. C. O. Salgado Potentiation of Bradykinin Effect by Angiotensin-Converting Enzyme Inhibition Does Not Correlate With Angiotensin-Converting Enzyme Activity in the Rat Mesenteric Arteries Hypertension, July 1, 2007; 50(1): 110 - 115. [Abstract] [Full Text] [PDF]

				C. de Aredes Brum, I. D. G. Duarte, R. C. Webb, and R. Leite Disruption of microtubular network attenuates histamine-induced dilation in rat mesenteric vessels Am J Physiol Cell Physiol, February 1, 2005; 288(2): C443 - C449. [Abstract] [Full Text] [PDF]

				D. L. Lee, R. Leite, C. Fleming, J. S. Pollock, R. C. Webb, and M. W. Brands Hypertensive Response to Acute Stress Is Attenuated in Interleukin-6 Knockout Mice Hypertension, September 1, 2004; 44(3): 259 - 263. [Abstract] [Full Text] [PDF]

				C. F. Santos, M. A. V. Caprio, E. B. Oliveira, M. C. O. Salgado, D. N. Schippers, D. H. Munzenmaier, and A. S. Greene Functional role, cellular source, and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H775 - H783. [Abstract] [Full Text] [PDF]

				F. A.W. Rabelo, E. M. Russo, M. C. O. Salgado, and E. B. Coelho Nonendothelial NO Blunts Sympathetic Response of Normotensive Rats but not of SHR Hypertension, September 1, 2001; 38(3): 565 - 568. [Abstract] [Full Text] [PDF]

				E. B. Coelho, G. Ballejo, and M. C. O. Salgado Nitric Oxide Blunts Sympathetic Response of Pregnant Normotensive and Hypertensive Rat Arteries Hypertension, September 1, 1997; 30(3): 585 - 588. [Abstract] [Full Text]