Hypertension, Vol 19, 713-716, Copyright © 1992 by American Heart Association
K Fujii, BL Weno, GL Baumbach and DD Heistad
The goal of the current study was to determine whether treatment of
hypertension reduces cerebral infarction after occlusion of the middle
cerebral artery in stroke-prone spontaneously hypertensive rats (SHRSPs).
Three-month-old SHRSPs received untreated drinking water or drinking water
containing cilazapril, an angiotensin converting enzyme inhibitor, or
hydralazine and hydrochlorothiazide. After 3 months of treatment, the left
middle cerebral artery was occluded and neurological deficit was evaluated.
Infarct volume was measured 3 days after occlusion using computer imaging
techniques from brain slices. Cilazapril and hydralazine with
hydrochlorothiazide were equally effective in reducing systolic blood
pressure in SHRSPs. One day after occlusion of the middle cerebral artery,
neurological deficit was decreased by both cilazapril and hydralazine with
hydrochlorothiazide compared with untreated SHRSPs, and the deficit 3 days
after occlusion was decreased significantly only by cilazapril. Infarct
volume was 178 +/- 7 mm3 (mean +/- SEM) in untreated SHRSPs, and it was
significantly reduced to 117 +/- 15 mm3 by hydralazine with
hydrochlorothiazide and to 101 +/- 17 mm3 by cilazapril. Infarct volume in
Wistar-Kyoto rats was 27 +/- 16 mm3. Thus, reduction in arterial pressure
by hydralazine with hydrochlorothiazide or an angiotensin converting enzyme
inhibitor is protective against focal cerebral ischemia in SHRSPs.
ARTICLES
Effect of antihypertensive treatment on focal cerebral infarction
Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa.
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