Hypertension, Vol 19, 717-720, Copyright © 1992 by American Heart Association
ML Bots, PJ Breslau, E Briet, AM de Bruyn, HH van Vliet, FA van den Ouweland, PT de Jong, A Hofman and DE Grobbee
The objective of the present study was to assess the prevalence of moderate
and severe stenosis of the right carotid artery in the elderly and its
associations with smoking, blood pressure, serum lipid levels, and
hemostatic factors. The Rotterdam Elderly Study is a recently started
single-center prospective follow-up study of a cohort of 11,854 elderly
people aged 55 years or more. In 1990, 954 participants of the Rotterdam
Elderly Study underwent ultrasonic duplex examination of the right internal
carotid artery. A reduction of the lumen diameter of 16- 49% was found in
29 people (3.0%). Severe stenosis (50% or more) was observed in 13 people
(1.4%). With differences in age, sex, and body mass index taken into
account, subjects with moderate-to-severe carotid artery disease had,
compared with participants without stenosis, lower mean high density
lipoprotein cholesterol levels (mean difference, 0.10 mmol/l; 95%
confidence interval, 0, 0.20) and higher mean fibrinogen levels
(difference, 0.24 g/l; 0.04, 0.45). Among them were more people with
hypertension (mean difference, 16%) and more current smokers (mean
difference, 13%). Factor VIIc and factor VIIIc activity was higher in
subjects with carotid artery disease, without, however, reaching
statistical significance (mean difference, 0.06 IU/ml [-0.01, 0.12] and
0.21 IU/ml [-0.05, 0.47], respectively). Our data suggest that
hypertension, smoking, and reduced serum high density lipoprotein
cholesterol levels, combined with unfavorable increases in hemostatic
factors, may be related to carotid artery disease in the elderly.
ARTICLES
Cardiovascular determinants of carotid artery disease. The Rotterdam Elderly Study
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
This article has been cited by other articles:
 |
|
 |
|
  M. de Weerd, J. P. Greving, A. W.F. de Jong, E. Buskens, and M. L. Bots Prevalence of Asymptomatic Carotid Artery Stenosis According to Age and Sex: Systematic Review and Metaregression Analysis Stroke, April 1, 2009; 40(4): 1105 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wasay, M. Azeemuddin, I. Masroor, Z. Sajjad, R. Ahmed, B. A. Khealani, M. A. Malik, M. B. Afridi, and A. Kamal Frequency and Outcome of Carotid Atheromatous Disease in Patients With Stroke in Pakistan Stroke, March 1, 2009; 40(3): 708 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Demircan, A. T. Sezgin, M. Baltali, O. Gulcan, S. Topcu, F. Yigit, T. Erol, R. Turkoz, H. Muderrisoglu, and B. Ozin Intima-Media Thickness in Patients With Rheumatic Mitral Stenosis Angiology, November 1, 2007; 58(5): 614 - 619. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Testa, F. A. Benedetto, B. Spoto, A. Pisano, G. Tripepi, F. Mallamaci, L. S. Malatino, and C. Zoccali The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease Nephrol. Dial. Transplant., July 1, 2006; 21(7): 1921 - 1926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Johnsen, E. B. Mathiesen, E. Fosse, O. Joakimsen, E. Stensland-Bugge, I. Njolstad, and E. Arnesen Elevated High-Density Lipoprotein Cholesterol Levels Are Protective Against Plaque Progression: A Follow-Up Study of 1952 Persons With Carotid Atherosclerosis The Tromso Study Circulation, July 26, 2005; 112(4): 498 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Honda, S. Sugiyama, K. Kugiyama, H. Fukushima, S. Nakamura, S. Koide, S. Kojima, N. Hirai, H. Kawano, H. Soejima, et al. Echolucent carotid plaques predict future coronary events in patients with coronary artery disease J. Am. Coll. Cardiol., April 7, 2004; 43(7): 1177 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-H. S. Oei, R. Vliegenthart, A. Hofman, M. Oudkerk, and J. C.M. Witteman Risk factors for coronary calcification in older subjects: The Rotterdam Coronary Calcification Study Eur. Heart J., January 1, 2004; 25(1): 48 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. W. de Sauvage Nolting, E. de Groot, A. H. Zwinderman, R. J. A. Buirma, M. D. Trip, and J. J. P. Kastelein Regression of Carotid and Femoral Artery Intima-Media Thickness in Familial Hypercholesterolemia: Treatment With Simvastatin Arch Intern Med, August 11, 2003; 163(15): 1837 - 1841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Oliviero, G. Scherillo, C. Casaburi, M. di Martino, A. di Gianni, R. Serpico, S. Fazio, and L. Sacca Prospective Evaluation of Hypertensive Patients with Carotid Kinking and Coiling: An Ultrasonographic 7-Year Study Angiology, March 1, 2003; 54(2): 169 - 175. [Abstract] [PDF]
|
|
|
|
 |
|
 D. N. O'Neal, G. Dragicevic, K. G. Rowley, M. Z. Ansari, N. Balazs, A. Jenkins, and J. D. Best A Cross-Sectional Study of the Effects of Type 2 Diabetes and Other Cardiovascular Risk Factors on Structure and Function of Nonstenotic Arteries of the Lower Limb Diabetes Care, January 1, 2003; 26(1): 199 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hollander, M.L. Bots, A. I. del Sol, P.J. Koudstaal, J.C.M. Witteman, D.E. Grobbee, A. Hofman, and M.M.B. Breteler Carotid Plaques Increase the Risk of Stroke and Subtypes of Cerebral Infarction in Asymptomatic Elderly: The Rotterdam Study Circulation, June 18, 2002; 105(24): 2872 - 2877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Redberg, P. Greenland, V. Fuster, K. Pyorala, S. N. Blair, A. R. Folsom, A. B. Newman, D. H. O'Leary, T. J. Orchard, B. Psaty, et al. Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group III: Risk Assessment in Persons With Diabetes Circulation, May 7, 2002; 105 (18): e144 - e152. [Full Text] [PDF]
|
|
|
|
 |
|
 M L Bots, P C Elwood, J T Salonen, A Freire de Concalves, J Sivenius, A Di Carlo, Y Nikitin, V Benetou, J Tuomilehto, P J Koudstaal, et al. Level of fibrinogen and risk of fatal and non-fatal stroke. EUROSTROKE: a collaborative study among research centres in Europe J Epidemiol Community Health, February 1, 2002; 56(90001): i14 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. BENEDETTO, F. MALLAMACI, G. TRIPEPI, and C. ZOCCALI Prognostic Value of Ultrasonographic Measurement of Carotid Intima Media Thickness in Dialysis Patients J. Am. Soc. Nephrol., November 1, 2001; 12(11): 2458 - 2464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Rubba, S. Panico, M. G. Bond, G. Covetti, E. Celentano, A. Iannuzzi, R. Galasso, M. A. Belisario, A. Pastinese, L. Sacchetti, et al. Site-Specific Atherosclerotic Plaques in the Carotid Arteries of Middle-Aged Women From Southern Italy: Associations With Traditional Risk Factors and Oxidation Markers Stroke, September 1, 2001; 32(9): 1953 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zureik, F. Kauffmann, P.-J. Touboul, D. Courbon, and P. Ducimetiere Association Between Peak Expiratory Flow and the Development of Carotid Atherosclerotic Plaques Arch Intern Med, July 9, 2001; 161(13): 1669 - 1676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.M. Rothwell The Interrelation between carotid, femoral and coronary artery disease Eur. Heart J., January 1, 2001; 22(1): 11 - 14. [PDF]
|
|
|
|
 |
|
 M. C. Whiteman, I. J. Deary, and F. G. R. Fowkes Personality and Social Predictors of Atherosclerotic Progression: Edinburgh Artery Study Psychosom Med, September 1, 2000; 62(5): 703 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Schmidt, J. Hulthe, J. Wikstrand, H. Gnarpe, J. Gnarpe, S. Agewall, and B. Fagerberg Chlamydia pneumoniae Seropositivity Is Associated With Carotid Artery Intima-Media Thickness Stroke, July 1, 2000; 31(7): 1526 - 1531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zureik, P. Ducimetiere, P.-J. Touboul, D. Courbon, C. Bonithon-Kopp, C. Berr, and C. Magne Common Carotid Intima-Media Thickness Predicts Occurrence of Carotid Atherosclerotic Plaques : Longitudinal Results From the Aging Vascular Study (EVA) Study Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1622 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. M. Bakker, F.-E. de Leeuw, P. J. Koudstaal, A. Hofman, and M. M. B. Breteler Cerebral CO2 reactivity, cholesterol, and high-density lipoprotein cholesterol in the elderly Neurology, February 22, 2000; 54(4): 987 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Greenland, J. Abrams, G. P. Aurigemma, M. G. Bond, L. T. Clark, M. H. Criqui, J. R. Crouse III, L. Friedman, V. Fuster, D. M. Herrington, et al. Prevention Conference V : Beyond Secondary Prevention : Identifying the High-Risk Patient for Primary Prevention : Noninvasive Tests of Atherosclerotic Burden : Writing Group III Circulation, January 4, 2000; 101 (1): e16 - e22. [Full Text] [PDF]
|
|
|
|
|
|
S. Kiechl and J. Willeit The Natural Course of Atherosclerosis : Part I: Incidence and Progression Arterioscler Thromb Vasc Biol, June 1, 1999; 19(6): 1484 - 1490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zureik, P.-J. Touboul, C. Bonithon-Kopp, D. Courbon, I. Ruelland, and P. Ducimetiere Differential Association of Common Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaques With Parental History of Premature Death From Coronary Heart Disease : The EVA Study Arterioscler Thromb Vasc Biol, February 1, 1999; 19(2): 366 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. M. Bakker, F.-E. de Leeuw, J. C. de Groot, A. Hofman, P. J. Koudstaal, and M. M. B. Breteler Cerebral vasomotor reactivity and cerebral white matter lesions in the elderly Neurology, February 1, 1999; 52(3): 578 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. O'Leary, J. F. Polak, R. A. Kronmal, T. A. Manolio, G. L. Burke, S. K. Wolfson, and The Cardiovascular Health Study Collaborative Rese Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke in Older Adults N. Engl. J. Med., January 7, 1999; 340(1): 14 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C J M Whitty, C L M Sudlow, and C P Warlow Investigating individual subjects and screening populations for asymptomatic carotid stenosis can be harmful J. Neurol. Neurosurg. Psychiatry, May 1, 1998; 64(5): 619 - 623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Lee, P. I. Mowbray, G. D.O. Lowe, A. Rumley, F. G. R. Fowkes, and P. L. Allan Blood Viscosity and Elevated Carotid Intima-Media Thickness in Men and Women : The Edinburgh Artery Study Circulation, April 21, 1998; 97(15): 1467 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Schmidt, R. Schmidt, K. Niederkorn, S. Horner, P. Becsagh, B. Reinhart, M. Schumacher, V. Weinrauch, and G. M. Kostner ß-Fibrinogen Gene Polymorphism (C148->T) Is Associated With Carotid Atherosclerosis : Results of the Austrian Stroke Prevention Study Arterioscler Thromb Vasc Biol, March 1, 1998; 18(3): 487 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Bots, A. Hofman, and D. E. Grobbee Increased Common Carotid Intima-Media Thickness : Adaptive Response or a Reflection of Atherosclerosis? Findings From the Rotterdam Study Stroke, December 1, 1997; 28(12): 2442 - 2447. [Abstract] [Full Text]
|
|
|
|
|
|
T. Mannami, M. Konishi, S. Baba, N. Nishi, and A. Terao Prevalence of Asymptomatic Carotid Atherosclerotic Lesions Detected by High-Resolution Ultrasonography and Its Relation to Cardiovascular Risk Factors in the General Population of a Japanese City : The Suita Study Stroke, March 1, 1997; 28(3): 518 - 525. [Abstract] [Full Text]
|
|
|
|
|
|
P. L. Allan, P. I. Mowbray, A. J. Lee, and F. G. R. Fowkes Relationship Between Carotid Intima-Media Thickness and Symptomatic and Asymptomatic Peripheral Arterial Disease: The Edinburgh Artery Study Stroke, February 1, 1997; 28(2): 348 - 353. [Abstract] [Full Text]
|
|
|
|
|
|
W.-H. Pan, C.-H. Bai, J.-R. Chen, and H.-C. Chiu Associations Between Carotid Atherosclerosis and High Factor VIII Activity, Dyslipidemia, and Hypertension Stroke, January 1, 1997; 28(1): 88 - 94. [Abstract] [Full Text]
|
|
|
|
|
|
D. H. O'Leary, J. F. Polak, R. A. Kronmal, P. J. Savage, N. O. Borhani, S. J. Kittner, R. Tracy, J. M. Gardin, T. R. Price, and C. D. Furberg Thickening of the Carotid Wall : A Marker for Atherosclerosis in the Elderly? Stroke, February 1, 1996; 27(2): 224 - 231. [Abstract] [Full Text]
|
|
|
|
|
|
J. R. Crouse, U. Goldbourt, G. Evans, J. Pinsky, A. R. Sharrett, P. Sorlie, W. Riley, and G. Heiss Risk Factors and Segment-Specific Carotid Arterial Enlargement in the Atherosclerosis Risk in Communities (ARIC) Cohort Stroke, January 1, 1996; 27(1): 69 - 75. [Abstract] [Full Text]
|
|
|
|
|
|
G. Rossi, A. Rossi, A. Sacchetto, E. Pavan, and A. C. Pessina Hypertensive Cerebrovascular Disease and the Renin-Angiotensin System Stroke, September 1, 1995; 26(9): 1700 - 1706. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Carolei, C. Marini, P. Nencini, C. Gandolfo, C. Motto, E. Zanette, M. Prencipe, and C. Fieschi Prevalence and outcome of symptomatic carotid lesions in young adults BMJ, May 27, 1995; 310(6991): 1363 - 1366. [Abstract] [Full Text]
|
|
|
|
|
|
J. Selhub, P. F. Jacques, A. G. Bostom, R. B. D'Agostino, P. W.F. Wilson, A. J. Belanger, D. H. O'Leary, P. A. Wolf, E. J. Schaefer, and I. H. Rosenberg Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis N. Engl. J. Med., February 2, 1995; 332(5): 286 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Kanter, C. H. Tegeler, L. A. Pearce, J. Weinberger, W. M. Feinberg, D. C. Anderson, C. R. Gomez, J. F. Rothrock, C. M. Helgason, and R. G. Hart Carotid Stenosis in Patients With Atrial Fibrillation: Prevalence, Risk Factors, and Relationship to Stroke in the Stroke Prevention in Atrial Fibrillation Study Arch Intern Med, June 27, 1994; 154(12): 1372 - 1377. [Abstract] [PDF]
|
|