This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nicholls, M. G. Articles by Greenhouse, J. Search for Related Content PubMed PubMed Citation Articles by Nicholls, M. G. Articles by Greenhouse, J.

Hypertension, Vol 2, 29-32, Copyright © 1980 by American Heart Association

ARTICLES

Plasma norepinephrine variations with dietary sodium intake

MG Nicholls, W Kiowski, AJ Zweifler, S Julius, MA Schork and J Greenhouse

Plasma catecholamine and renin activity levels were measured across a range of dietary sodium intakes (10--300 mEq/day) in 20 normal male volunteers. Supine plasma norepinephrine levels presented a triphasic pattern in relation to urine sodium, whereas epinephrine levels were not significantly altered by sodium intake, and renin showed the well- known hyperbolic relationship to urine sodium excretion. Highest supine norepinephrine values occurred at low salt intakes, the lowest when sodium excretion was between 100 and 180 mEq/day, and intermediate when sodium excretion was greater than 180 mEq/day. These findings show that sodium intake is an important consideration in the interpretation of plasma norepinephrine levels.

This article has been cited by other articles:

				E. D. Frohlich The Salt Conundrum: A Hypothesis Hypertension, July 1, 2007; 50(1): 161 - 166. [Full Text] [PDF]

				G. Grassi, R. Dell'Oro, G. Seravalle, G. Foglia, F. Q. Trevano, and G. Mancia Short- and Long-Term Neuroadrenergic Effects of Moderate Dietary Sodium Restriction in Essential Hypertension Circulation, October 8, 2002; 106(15): 1957 - 1961. [Abstract] [Full Text] [PDF]

				M. Volpe, B. Gigante, I. Enea, A. Porcellini, R. Russo, M. A. Lee, P. Magri, G. Condorelli, C. Savoia, K. Lindpaintner, et al. Role of Tissue Renin in the Regulation of Aldosterone Biosynthesis in the Adrenal Cortex of Nephrectomized Rats Circ. Res., November 19, 1997; 81(5): 857 - 864. [Abstract] [Full Text]

				G. S. FRANCIS, S. R. GOLDSMITH, T. B. LEVINE, M. T. OLIVARI, and J. N. COHN The Neurohumoral Axis in Congestive Heart Failure Ann Intern Med, September 1, 1984; 101(3): 370 - 377. [Abstract] [PDF]